| Project/Area Number |
21592036
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Toyama |
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Principal Investigator |
FUSE Hideki 富山大学, 大学院・医学薬学研究部(医学), 教授 (40143292)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Kenji 富山大学, 大学病院, 助教 (20401854)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 腫瘍学 / 癌 / HAI-1 / 転移・浸潤 / HGF / 前立腺 / HGF関連因子 |
|---|
| Research Abstract |
We investigated manifestation in prostate cancer of hepatocyte growth factor activator(HGFA) inhibitor type 1(HAI-1). HAI-1 is inhibitor for HGFA. HAI-1 appeared in prostate epithelial cell, but did not appear in stromal cell by immunohistochemistry(IHC). Examination with prostate biopsy specimens, the HAI-1 expression was not observed for some case. We defined HAI-1 expression intensity as negative, weak, moderate and strong. We analyzed the relationship between HAI-1 expression and several clinicopathological factors. Expression of HAI-1 by IHC in patients with prostate cancer was significantly higher than those with negative for prostate biopsy. There were no significant differences in HAI-1 expression with respect to clinical stages or tumor grades. However castration resistance prostate cancer showed significantly lower HAI-1 expression than untreated metastatic prostate cancer.
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