| Project/Area Number |
21592040
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
CYANO Tokuhiro 滋賀医科大学, 医学部, 准教授 (40346028)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 腎細胞癌 / 精巣腫瘍 / エピジェネティクス / 胎児性癌 / 遺伝子治療 / 多嚢胞性腎細胞癌 / Gタンパク質共役受容体 / DMNT3L / GPCR91 / GPCR99 / renal cell cancer / testicular germ cell tumor |
|---|
| Research Abstract |
We have analyzed various epigenetic profiles in renal and urinary tumors, and identified that the underlying mechanisms to undergo or maintain demethylation of DNA repetitive sequences(LINE1 and Alu repeats) differ between testicular germ cell tumors(TGCTs) and cancer cells of somatic tissue origin. These methylation patterns most likely reflect the origin of TGCTs. Further elucidation of the mechanisms behind the maintenance of DNA hypomethylation in TGCTs is necessary in order to clarify the basic biology of this unique neoplasm.
Otherwise, we have established the potential of SOX2 silencing therapy for embryonal carcinomas, although further improvements are needed in SOX2-siRNA delivery to the tumor.
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