| Project/Area Number |
21592041
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
KIM Tetsusyo 滋賀医科大学, 医学部, 非常勤講師 (10204968)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
INOUE Hirokazu 滋賀医科大学, 医学部, 准教授 (30176440)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 尿路上皮癌 / cyclin D1b / 癌遺伝子 / スプライシング / Tgマウス / cyclin D1 |
|---|
| Research Abstract |
Human cyclin D1b gene generates two major isoforms, cyclin D1a and cyclin D1b by alternative splicing. Cyclin D1b, which lacks the ability to bind to CDK4 and phosphorylated Rb, is hardly expressed in normal tissues but is frequently expressed in certain types of cancer tissues including bladder cancers. To clarify the oncogenic potential of cyclin D1b variant, we engineered transgenic(Tg) mice with the human cyclin D1b transgene by pCAGGS promoter, which is able to ubiquitously express transgene. We found that rectal tumors including adenocarcinoma, sessile serrated adenoma(SSA), traditional serrated adenoma(TSA) and hyperplastic polyp(HHP) were generated in about 60% of female Tg mice. This Tg mouse would become a good model of colorectal carcinogenesis via the serrated pathway.
|
