| Project/Area Number |
21592043
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Osamu 京都大学, 医学研究科, 教授 (90260611)
兼松 明弘 京都大学, 医学研究科, 講師 (90437202)
渡部 淳 京都大学, 医学研究科, 助教 (10452335)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | PURA LASP-1 / 前立腺癌 / 去勢抵抗性 / PURA / LASP-1 / LASP1 / ATF3 / GADD45A / S100P / HERPUD1 |
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| Research Abstract |
The aim of this research is to analyze whether a nuclear matrix protein, Purine-element binding protein alpha(PURA), is useful for exploration for a new molecular target of hormone refractory prostate cancer.
Overexpression of PURA obviously lowered the growth speed of PC3 cells in vivo, and by immunohistochemistry, Ki67 expression was weaker in PC3 cells with PURA overexpression than in control PC3 cells. And we have established tissue microarray, including 22 cases of castration resistant prostate cancer, which were obtained by TUR. Using this microarray, we are planning to ask how those expression changes with progression of prostate cancer.
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