The role of chronic inflammation and innate immunity in prostate carcinogenesis

• Project/Area Number: 21592044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Osaka University
• Principal Investigator: NONOMURA Norio 大阪大学, 医学系・研究科, 教授 (30263263)
• Co-Investigator(Kenkyū-buntansha): TAKAYAMA Hitoshi 大阪大学, 大学院・医学系・研究科, 講師 (50403051) ; NAKAI Yasutomo 大阪大学, 大学院・医学系・研究科, 助教 (20432479) ; NAKAYAMA Masashi 大阪府立成人病センター, 泌尿器科, 副部長 (40379178)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 前立腺癌 / 慢性炎症 / 自然免疫 / 動物モデル / 化学発癌 / リポポリサッカライド(LPS)

Research Abstract

F344 rat prostatitis model using lipopolysaccharide(LPS) was established. PhIP(2-amino-1-methyl-6-phenylimidazo[ 4, 5-b] pyridine)-induced abnormal proliferation of rat prostate epithelial cells was enhanced by LPS-induced inflammation. Moreover, clinicopathological studies using human prostate biopsy specimens suggest that infiltration of mast cells or macrophages positively correlated with occurrence or progression of prostate cancer.

Research Products

• [Journal Article] Androgen-regulated transcriptional control of sialyltransferases in prostate cancer cells (2012)
  • Author(s): Nonomura N, Takayama H, et al
  • Journal Title: PLoS One Volume: e31234 Issue: 2 Pages: 1570-1573
  • DOI: 10.1371/journal.pone.0031234
  • Peer Reviewed
• [Journal Article] 前立腺炎後の組織修復過程における骨髄由来細胞(Bone marrow-derived cells)の役割についての検討 (2011)
  • Author(s): 中井康友, 高山仁志, 野々村祝夫
  • Journal Title: 泌尿器外科 Volume: 24(8) Pages: 1235-1237
  • Peer Reviewed
• [Journal Article] 【前立腺癌(第2版)-基礎・臨床研究のアップデート-】基礎前立腺癌のアンドロゲン非依存性進展副腎ステロイドの役割(解説/特集) (2011)
  • Author(s): 中井康友、辻村晃、野々村祝夫
  • Journal Title: 日本臨床 Volume: 69巻(増刊) Pages: 112-116
  • Peer Reviewed
• [Journal Article] Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer (2011)
  • Author(s): Nonomura N, Takayama H, Nakayama M, Nakai Y, Kawashima A, Mukai M, Nagahara A, Aozasa K, Tsujimura A.
  • Journal Title: BJU Int Volume: 107(12) Pages: 1918-22
  • Peer Reviewed
• [Journal Article] Infiltration of tumour-associated macrophages in prostatebiopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer (2011)
  • Author(s): Nonomura N, Takayama H, et al
  • Journal Title: BJU Int Volume: 107 Issue: 12 Pages: 253-259
  • DOI: 10.1111/j.1464-410x.2010.09804.x
  • Peer Reviewed
• [Journal Article] A case of primary malignant lymphoma of the prostate (2011)
  • Author(s): Kishimoto N, Takao T, Nonomura N, et al
  • Journal Title: Hinyokjka Kiyo Volume: 57 Pages: 445-449
  • Peer Reviewed
• [Journal Article] Expression of ganglisides, GD1a and sialyl paragloboside, is regulated by NF-κB-dependent transcriptional control of α2,3-sialyltransferase I, II and VI in human castration-resistant prostate cancer cells (2011)
  • Author(s): Hatano K, Miyamoto Y, Nonomura Nand Kaneda Y.
  • Journal Title: Int J Cancer Volume: 129 Issue: 8 Pages: 1838-1847
  • DOI: 10.1002/ijc.25860
  • Peer Reviewed
• [Journal Article] Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. (2011)
  • Author(s): Nonomura N, Takayama H, Nakayama M, Nakai Y, Kawashima A, Mukai M, Nagahara A, Aozasa K, Tsujimura A.
  • Journal Title: BJU International Volume: (In press)
  • Peer Reviewed
• [Journal Article] Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate (2010)
  • Author(s): Nonomura N, Takayama H, Kawashima A, Mukai M, Nagahara A, Nakai Y, Nakayama M, Tsujimura A, Nishimura K, Aozasa K, Okuyama A.
  • Journal Title: Cancer Sci Volume: 101(6) Pages: 1570-1573
  • NAID: 10026594241
  • Peer Reviewed
• [Journal Article] Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate. (2010)
  • Author(s): Nonomura N, Takayama H, Kawashima A, Mukai M, Nagahara A, Nakai Y, Nakayama M, Tsujimura A, Nishimura K, Aozasa K, Okuyama A.
  • Journal Title: Cancer Science Volume: 101 Pages: 1570-1573
  • NAID: 10026594241
  • Peer Reviewed
• [Journal Article] Increased infiltration of tumor associated macrophages is associated with poor prognosis of bladder carcinoma in situ after intravesical bacillus Calmette-Guerin instillation (2009)
  • Author(s): Takayama H, Nishimura K, Tsujimura A, Nakai Y, Nakayama M, Aozasa K, Okuyama A, Nonomura N.
  • Journal Title: J Urol Volume: 181(4) Pages: 1894-1900
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor receptor 1 expression in pelvic lymph nodes predicts the risk of cancer progression after radical prostatectomy (2009)
  • Author(s): Fujita K, Nakayama M, Nakai Y, Takayama H, Nishimura K, Ujike T, Nishimura K, Aozasa K, Okuyama A, Nonomura N.
  • Journal Title: Cancer Sci Volume: 100(6) Pages: 1047-1050
  • NAID: 10025146519
  • Peer Reviewed
• [Journal Article] Decreased infiltration of the macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate
  • Author(s): Nonomura N, Takayama H, et al.
  • Journal Title: Cancer Science (in press)
  • NAID: 10026594241
  • Peer Reviewed
• [Presentation] HVJ-Eを用いた去勢抵抗性前立腺癌に対する新たながん治療の開発 (2012)
  • Author(s): 波多野浩士
  • Organizer: 泌尿器科分子・細胞研究会
  • Place of Presentation: 札幌市(招待講演)
  • Year and Date: 2012-02-11
• [Presentation] 前立腺発癌における炎症の役割-動物実験による結果から- (2011)
  • Author(s): 中井康友
  • Organizer: 日本アンドロロジー学会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-07-23
• [Presentation] Increased infiltration of mast cells infiltrating in non-malignant biopsy is associated with detection of prostate cancer (2011)
  • Author(s): Takayama H, Hatano K, Satoh M, Kawashima A, Mukai M, Nagahara A, Nakai Y, Nonomura N.
  • Organizer: Annual Meeting of the American Urological Association
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-05-17
• [Presentation] Increased infiltration of Mast cells in non-malignant biopsy Is Associated with Detection of Prostate Cancer (2011)
  • Author(s): 高山仁志
  • Organizer: アメリカ泌尿器科学会
  • Place of Presentation: ワシントンDCアメリカ合衆国(招待講演)
  • Year and Date: 2011-05-17
• [Presentation] 食餌由来の発癌物質である2-amino-1-methyl-6-phenylimidazo[ 4, 5-b] pyridine(PhIP)投与により発生するラット前立腺癌の発癌過程における肥満細胞の役割の検討 (2011)
  • Author(s): 中井康友、高山仁志、野々村祝夫
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-04-24
• [Presentation] 膀胱上皮内癌(CIS)に対するBCG膀胱内注入療法の予後予測因子としての肥満細胞出現の有用性の検討 (2011)
  • Author(s): 高山仁志、波多野浩士、佐藤元孝、河嶋厚成、向井雅俊、永原啓、植村元秀、岡大三、中井康友、野々村祝夫
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-04-24
• [Presentation] 食餌由来の発癌物質である2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine(PhIP)投与により発生するラット前立腺癌の発癌過程における肥満細胞の役割の検討 (2011)
  • Author(s): 中井康友
  • Organizer: 日本泌尿器科学会
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2011-04-24
• [Presentation] 新たながん治療に向けたアンドロゲン非依存性前立腺癌のHVJ-E感受性機構の研究 (2011)
  • Author(s): 波多野浩士
  • Organizer: 日本泌尿器科学会
  • Place of Presentation: 名古屋市(招待講演)
  • Year and Date: 2011-04-22
• [Presentation] 前立腺癌における炎症の役割について-動物実験における検討- (2011)
  • Author(s): 中井康友、中山雅志、高山仁志、野々村祝夫
  • Organizer: 第99回日本泌尿器科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-04-21
• [Presentation] 前立腺癌における炎症の役割について動物実験における検討 (2011)
  • Author(s): 中井康友
  • Organizer: 日本泌尿器科学会
  • Place of Presentation: 名古屋市(未来講演)(招待講演)
  • Year and Date: 2011-04-21
• [Presentation] Increased number of mast cells infiltrating in non-malignant biopsy is associated with detection of prostate cancer (2011)
  • Author(s): Takayama H, Hatano K, Satoh M, Kawashima A, Mukai M, Nagahara A, Nakai Y, Nonomura N.
  • Organizer: Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-04-05
• [Presentation] Increased infiltration of mast cells in non-malignant biopsy is associated with detection of prostate cancer (2010)
  • Author(s): 高山仁志、佐藤元孝、波多野浩士、河嶋厚成、向井雅俊、永原啓、植村元秀、岡大三、中井康友、中山雅志、西村和郎、青笹克之、野々村祝夫
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-24
• [Presentation] The effects of inflammation on the occurrence and progression of the prostate cancer (2010)
  • Author(s): 野々村祝夫、中井康友、中山雅志、西村和郎
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪市(招待講演)
  • Year and Date: 2010-09-24
• [Presentation] Prostatitis promotes prostate carcinogenesis induced by 2-amino-1-methyl-6-phenylimidazo[ 4, 5-b] pyridine(PhIP) (2010)
  • Author(s): 中井康友、向井雅俊、鈴木崇、土屋睦美、房前裕順、永原啓、中山雅志、高山仁志、辻川和丈、野々村祝夫
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] Prostatitis promotes prostate carcinogenesis induced by 2-amino-1-methyl-6-imidazo[4,5-b]pyridine(PhIP) (2010)
  • Author(s): 中井康友、向井雅俊、鈴木崇、土屋睦美、房前裕順、永原啓、中山雅志、高山仁志、辻川和丈、野々村祝夫
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2010-09-23
• [Presentation] 前立腺初回生検癌陰性標本における肥満細胞の再生検指標の可能性の検討 (2010)
  • Author(s): 高山仁志、波多野浩士、河嶋厚成、向井雅俊、永原啓、植村元秀、岡大三、中井康友、中山雅志、野々村祝夫、奥山明彦
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-29
• [Presentation] 前立腺炎はPhIP(2-amino-1-methyl-6-phenylimidazo[ 4, 5-b] pyridine)による前立腺発癌を促進する (2010)
  • Author(s): 中井康友、向井雅俊, 鈴木崇, 房前裕順, 波多野浩士、河嶋厚成、永原啓、中山雅志、高山仁志、辻川和丈、野々村祝夫、奥山明彦
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-27
• [Presentation] 前立腺炎はPhIP(2-amino-1-methyl-6-imidazo[4,5-b]pyridine)による前立腺発癌を促進する (2010)
  • Author(s): 中井康友、向井雅俊、鈴木崇、房前裕順、波多野浩志、河嶋厚成、永原啓、中山雅志、高山仁志、辻川和丈、野々村祝夫、奥山明彦
  • Organizer: 第98回日本泌尿器科学会総会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-04-27
• [Presentation] Vegfr1 expression in pelvic lymph nodes predicts the risk of biochemical recurrence after radical prostatectomy (2009)
  • Author(s): Nakayama M, Fujita K, Kawashima A, Mukai M, Nagahara A, Nakai Y, Takayama H, Nishimura H, Aozasa K, Okuyama A, Nonomura N.
  • Organizer: Annual Meeting of the American Urological Association
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-04-26
• [Presentation] 初回生検陰性標本におけるMacrophage Scavenger Receptor(MSR)とTumor-associated Macrophage(TAM)の再生検指標の可能性の検討 (2009)
  • Author(s): 高山仁志、野々村祝夫、河嶋厚成、向井雅俊、永原啓、芝政宏、岡大三、中井康友、中山雅志、井上均、西村和郎、奥山明彦
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山市
  • Year and Date: 2009-04-19
• [Presentation] 新規ラット前立腺炎モデルの確立 (2009)
  • Author(s): 中井康友, 河嶋厚成, ら
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山市
  • Year and Date: 2009-04-16