The role of chronic inflammation and innate immunity in prostate carcinogenesis
| Project/Area Number |
21592044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
NONOMURA Norio 大阪大学, 医学系・研究科, 教授 (30263263)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYAMA Hitoshi 大阪大学, 大学院・医学系・研究科, 講師 (50403051)
NAKAI Yasutomo 大阪大学, 大学院・医学系・研究科, 助教 (20432479)
NAKAYAMA Masashi 大阪府立成人病センター, 泌尿器科, 副部長 (40379178)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 前立腺癌 / 慢性炎症 / 自然免疫 / 動物モデル / 化学発癌 / リポポリサッカライド(LPS) |
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| Research Abstract |
F344 rat prostatitis model using lipopolysaccharide(LPS) was established. PhIP(2-amino-1-methyl-6-phenylimidazo[ 4, 5-b] pyridine)-induced abnormal proliferation of rat prostate epithelial cells was enhanced by LPS-induced inflammation. Moreover, clinicopathological studies using human prostate biopsy specimens suggest that infiltration of mast cells or macrophages positively correlated with occurrence or progression of prostate cancer.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate2010
Author(s)
Nonomura N, Takayama H, Kawashima A, Mukai M, Nagahara A, Nakai Y, Nakayama M, Tsujimura A, Nishimura K, Aozasa K, Okuyama A.
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Journal Title
Cancer Sci
Volume: 101(6)
Pages: 1570-1573
NAID
Related Report
Peer Reviewed
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[Journal Article] Decreased infiltration of macrophage scavenger receptor-positive cells in initial negative biopsy specimens is correlated with positive repeat biopsies of the prostate.2010
Author(s)
Nonomura N, Takayama H, Kawashima A, Mukai M, Nagahara A, Nakai Y, Nakayama M, Tsujimura A, Nishimura K, Aozasa K, Okuyama A.
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Journal Title
Cancer Science
Volume: 101
Pages: 1570-1573
NAID
Related Report
Peer Reviewed
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[Presentation] Vegfr1 expression in pelvic lymph nodes predicts the risk of biochemical recurrence after radical prostatectomy2009
Author(s)
Nakayama M, Fujita K, Kawashima A, Mukai M, Nagahara A, Nakai Y, Takayama H, Nishimura H, Aozasa K, Okuyama A, Nonomura N.
Organizer
Annual Meeting of the American Urological Association
Place of Presentation
Chicago, USA
Year and Date
2009-04-26
Related Report
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