Identification of molecules associated with intravesical recurrence of non-muscle invasive bladder cancer and the development of novel therapeutic strategy based on the molecular mechanism

• Project/Area Number: 21592045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Kobe University
• Principal Investigator: MIYAKE Hideaki 神戸大学, 大学院・医学研究科, 准教授 (60379435)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 表在性膀胱癌 / 再発 / 細胞周期 / 細胞接着 / EMT / siRNA / HSP70 / 血管新生 / カドヘリン / p27 / β4 interin / eithelial-to-mesenhymal transition / 免疫組織化学染色 / 再発予防 / β4 integrin / epithelial-to-mesenhymal transition

Research Abstract

Through the evaluation of molecules associated with cell cycle, cell adherence and EMT, we developed predictive systems for intravesical recurrence of non-muscle invasive bladder cancer. In addition, we suggested the usefulness of novel therapeutic strategy targeting these molecules for preventing intravesical recurrence of non-muscle invasive bladder cancer.

Research Products

• [Journal Article] Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract is associated with disease recurrence in patients undergoing nephroureterectomy (2011)
  • Author(s): Muramaki M, Miyake H, Terakawa T, Kusuda Y, Fujisawa M
  • Journal Title: Urology Volume: 78
• [Journal Article] Expression of integrin proteins in non-muscle invasive bladder cancer : significance of intravesical recurrence following transurethral resection (2011)
  • Author(s): Behnsawy HM, Miyake H, Abdalla MA, Sayed MA, Ahmed AI, Fujisawa M
  • Journal Title: BJU International Volume: 107 Pages: 240-246
• [Journal Article] Expression of cell cycle-associated proteins in non-muscle invasive bladder cancer : correlation with intravesical recurrence following transurethral resection (2011)
  • Author(s): Behnsawy HM, Miyake H, Abdalla MA, Sayed MA, Ahmed AI, Fujisawa M
  • Journal Title: Urologic Oncology Volume: 29 Pages: 495-501
• [Journal Article] Expression profile of E-cadherin and N-cadherin in urothelial carcinoma of the upper urinary tract is associated with disease recurrence in patients undergoing nephroureterectomy (2011)
  • Author(s): Miyake H, (他4名, 2番目)
  • Journal Title: Urology Volume: 78
  • Peer Reviewed
• [Journal Article] Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells (2011)
  • Author(s): Miyake H, (他3名, 2番目)
  • Journal Title: Urologic Oncology Volume: (in press)(掲載確定)
  • Peer Reviewed
• [Journal Article] Expression profile of E-cadherin and N-cadherin in non-muscle invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection (2010)
  • Author(s): Miyake H, (他5名, 2番目)
  • Journal Title: Urologic Oncology Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Expression of integrin proteins in non-muscle invasive bladder cancer : significance of intravesical recurrence following transurethral resection (2010)
  • Author(s): Miyake H, (他5名, 2番目)
  • Journal Title: BJU International Volume: 107 Pages: 240-246
  • Peer Reviewed
• [Journal Article] Significance of uracil/tegafur for preventing intravesical recurrence of non-muscle invasive urothelial carcinoma of the bladder
  • Author(s): Harada K, Miyake H, Terakawa TI, Fujisawa M
  • Journal Title: Current Urology Volume: (in press)
• [Journal Article] Small interfering RNA targeting heat shock protein 70 enhances chemosensitivity in human bladder cancer cells
  • Author(s): Behnsawy HM, Miyake H, Kusuda Y, Fujisawa M
  • Journal Title: Urologic Oncology Volume: (in press)
• [Journal Article] Expression profile of E-cadherin and N-cadherin in non-muscle invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection
  • Author(s): Muramaki M, Miyake H, Terakawa T, Kumano M, Sakai I, Fujisawa M
  • Journal Title: Urologic Oncology Volume: (in press)
• [Journal Article] Expression of cell cycle-associated proteins in non-muscle invasive bladder cancer : correlation with intravesical recurrence following transurethral resection
  • Author(s): Miyake H, 他5名(2番目)
  • Journal Title: Urol Oncol (in press, 掲載確定)
  • Peer Reviewed
• [Journal Article] Expression profile of E-cadherin and N-cadherin in non-muscle invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection
  • Author(s): Miyake H, 他5名(2番目)
  • Journal Title: Urol Oncol (in press, 掲載確定)
  • Peer Reviewed
• [Presentation] Expression of cell cycle-associated proteins in non-muscle invasive bladder cancer : Correlation with intravesical recurrence following transurethral resection (2012)
  • Author(s): Hideaki Miyake, Hosny M Behnsaway, Masato Fujisawa
  • Organizer: 第27回EAU Annual Meeting
  • Place of Presentation: Paris
• [Presentation] Induction of angiogenic inhibitor, GBL in patients with non-muscle invasive bladder cancer following treatment with UFT (2011)
  • Author(s): Miyake H, (他7名,1番目)
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 愛知県がんセンター(愛知県)
  • Year and Date: 2011-10-04
• [Presentation] Induction of angiogenic inhibitor, GBL in patients with non-muscle invasive bladder cancer following treatment with UFT (2011)
  • Author(s): Hideaki Miyake, Tomoaki Terakawa, Iori Sakai, Junya Furukawa, ken-ichi Harada, Yuji Kusuda, Mototsugu Muramaki, Masato Fujisawa
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
• [Presentation] CHARACTERIZATION OF β4-INTEGRIN-MEDIATED CYTOTOXIC EFFECT OF AexU, A TYPE THREE SECRETION SYSTEM EFFECTOR, ON HUMAN PROSTATE CANCER PC3 CELLS (2010)
  • Author(s): Miyake H, (他2名, 2番目)
  • Organizer: American Urological Association Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2010-05-30
• [Presentation] Growth inhibition and chemosensitization in human bladder cancer KoTCC-1 cells by siRNA targeting heat shock protein-70 (2010)
  • Author(s): Hideaki Miyake, Tomoaki Terakawa, Iori Sakai, Junya Furukawa, Yuji Kusuda, Mototsugu Muramaki, Atsushi Takenaka, Masato Fujisawa
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
• [Presentation] Expression of cell cycle-associated proteins in superficial bladder cancer : correlation with intravesical recurrence following transurethral resection (2009)
  • Author(s): Miyake H, 他5名(2番目)
  • Organizer: American Urological Association Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-04-28