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Identification of gene signatures associated with renal tumor characteristics and its clinical applications

Research Project

Project/Area Number 21592053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionYokohama City University

Principal Investigator

YAO Masahiro  横浜市立大学, 医学研究科, 准教授 (00260787)

Co-Investigator(Kenkyū-buntansha) NAKAIGAWA Noboru  横浜市立大学, 医学研究科, 准教授 (00237207)
NAGASHIMA Yoji  横浜市立大学, 医学研究科, 准教授 (10217995)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腎細胞癌 / 遺伝子発現 / 予後 / 淡明細胞型 / PTHLH / PLTP
Research Abstract

Renal cell carcinomas(RCCs) are morphologically and genetically heterogeneous tumors and present diverse clinical courses. We selected differentially expressed gene-set between metastasis-positive and-negative phenotype from the DNA microarray data. We then focus on the three genes(AQP1, PLTP, and PTHLH) and confirmed their expression levels using quantitative reverse transcriptase PCR in more than 500 renal tumors. Each of the three genes presented unique expression patterns according to the renal tumor histology. We also demonstrated that each gene is tightly associated with clear cell RCC patient survivals. These data suggested that the three genes provide useful diagnostic and prognostic information for patients with RCC.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009

All Journal Article (24 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma2011

    • Author(s)
      Morris MR, Ricketts CJ, Gentle D, McRonald F, Carli N, Khalili H, Brown M, Kishida T, Yao M, Banks RE, Clarke N, Latif F, Maher ER
    • Journal Title

      Oncogene

      Volume: 30 Pages: 1390-1401

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Copy number profiling in von Hippel-Lindau disease renal cell carcinoma2011

    • Author(s)
      Shuib S, Wei W, Sur H, Morris MR, McMullan D, Rattenberry E, Meyer E, Maxwell P, Kishida T, Yao M, Latif F, Maher ER
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 50 Pages: 479-882

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【腎細胞癌の分子標的治療】腎細胞癌の分子標的治療の理論的根拠(解説/特集)2011

    • Author(s)
      中井川昇, 矢尾正祐
    • Journal Title

      医学のあゆみ

      Volume: 236 Pages: 1085-1089

    • Related Report
      2011 Final Research Report
  • [Journal Article] (Session1)疫学、診断(画像、病理、分子発生学)、予後因子腎癌分子発生学2011

    • Author(s)
      矢尾正祐, 中井川昇, 長嶋洋治, 岸田健
    • Journal Title

      泌尿器外科

      Volume: 24 Pages: 715-716

    • Related Report
      2011 Final Research Report
  • [Journal Article] Copy number profiling in von Hippel-Lindau disease renal cell carcinoma2011

    • Author(s)
      Shuib S, Yao M, et al
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 50 Issue: 7 Pages: 479-482

    • DOI

      10.1002/gcc.20865

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎癌分子発生学2011

    • Author(s)
      矢尾正祐, 他
    • Journal Title

      泌尿器外科

      Volume: 24特増 Pages: 715-716

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma2010

    • Author(s)
      Morris MR, Ricketts C, Gentle D, Abdulrahman M, Clarke N, Brown M, Kishida T, Yao M, Latif F, Maher ER
    • Journal Title

      Oncogene

      Volume: 29 Pages: 2104-2117

    • Related Report
      2011 Final Research Report
  • [Journal Article] Molecular genetic events associated with renal cell carninoma and its implication to treatment by molecular target therapy2010

    • Author(s)
      Kishida T, Yao M, Uemura H, Ohlmann C, Tomita Y, Bukowski RM, Naito S
    • Journal Title

      Int J Urol

      Volume: 17 Pages: 198-205

    • NAID

      10027257218

    • Related Report
      2011 Final Research Report
  • [Journal Article] 腎癌の病理分類2010

    • Author(s)
      長嶋洋治, 稲山嘉明, 青木一郎, 矢尾正祐
    • Journal Title

      日本臨床

      Volume: 68 Pages: 36-44

    • Related Report
      2011 Final Research Report
  • [Journal Article] 腎癌の癌遺伝子・癌抑制遺伝子2010

    • Author(s)
      矢尾正祐, 近藤慶一, 中井川昇
    • Journal Title

      日本臨床

      Volume: 68 Pages: 25-29

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【病理形態学キーワード】腎乳頭状構築2010

    • Author(s)
      長嶋洋治, 小林志津子, 村上あゆみ, 青木一郎, 矢尾正祐
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 202-203

    • Related Report
      2011 Final Research Report
  • [Journal Article] 小径腎腫瘍の診断と治療Update2010

    • Author(s)
      長嶋洋治, 青木一郎, 稲山嘉明, 矢尾正祐
    • Journal Title

      小径腎腫瘍の病理診断(解説/特集)

      Volume: 84 Pages: 15-20

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【腎腫瘍up to date 2010s】腎腫瘍の分子生物学2010

    • Author(s)
      矢尾正祐, 中井川昇, 近藤慶一, 長嶋洋治
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 1037-1042

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【腎腫瘍up to date 2010s】乳頭状腎細胞癌と集合管癌2010

    • Author(s)
      長嶋洋治, 青木一郎, 稲山嘉明, 矢尾正祐, 松嵜理
    • Journal Title

      病理と臨床

      Volume: 28 Pages: 1048-1052

    • Related Report
      2011 Final Research Report
  • [Journal Article] 腎癌の癌遺伝子・癌抑制遺伝子2010

    • Author(s)
      矢尾正祐、中井川昇, 他
    • Journal Title

      日本臨床

      Volume: 68巻増刊 Pages: 25-29

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 腎腫瘍の分子生物学2010

    • Author(s)
      矢尾正祐、中井川昇, 他
    • Journal Title

      病理と臨床

      Volume: 28巻10号 Pages: 1037-1042

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Expression of Aquaporin 1 in primary renal tumors : A prognostic indicator for clear-cell renal cell carcinoma2009

    • Author(s)
      Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida T, Kubota Y, Nagashima Y, Yao M.
    • Journal Title

      Eur Urol

      Volume: 56 Pages: 690-698

    • Related Report
      2011 Final Research Report
  • [Journal Article] Epithelioid angiomyolipoma of the kidney2009

    • Author(s)
      Kato I, Inayama Y, Yamanaka S, Ohshiro H, Gomi K, Shirai S, Aoki I, Uemura H, Miyoshi Y, Kubota Y, Yao M, Nagashima Y
    • Journal Title

      Pathol Int

      Volume: 59 Pages: 38-43

    • NAID

      10027378955

    • Related Report
      2011 Final Research Report
  • [Journal Article] CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma2009

    • Author(s)
      McRonald FE, Morris MR, Gentle D, Winchester L, Baban D, Ragoussis J, Clarke NW, Brown MD, Kishida T, Yao M, Latif F, Maher ER
    • Journal Title

      Mol Cancer

      Volume: 8(31)

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【腎における細胞内シグナル伝達と病態生理】腎細胞癌におけるシグナル伝達2009

    • Author(s)
      中井川昇, 矢尾正祐, 窪田吉信
    • Journal Title

      腎と透析

      Volume: 67 Pages: 387-381

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【泌尿器画像診断update】腎腫瘍の病理(解説/特集)2009

    • Author(s)
      長嶋洋治, 古林直人, 加川絵理子, 青木一郎, 稲山嘉明, 矢尾正祐
    • Journal Title

      臨床画像

      Pages: 6-18

    • Related Report
      2011 Final Research Report
  • [Journal Article] Expression of Aquaporin 1 in primary renal tumors : A prognostic indicator for clear-cell renal cell carcinoma2009

    • Author(s)
      Huang Y, Yao M, 他
    • Journal Title

      Eur Urol. 56(4)

      Pages: 690-698

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎疾患の病態生理 腎腫大のメカニズム編 腎細胞癌(総説)2009

    • Author(s)
      中井川昇, 矢尾正祐, 他
    • Journal Title

      腎と透析 66(4)

      Pages: 399-403

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 腎細胞癌におけるシグナル伝達2009

    • Author(s)
      中井川昇, 矢尾正祐, 他
    • Journal Title

      腎と透析 67(3)

      Pages: 387-381

    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎腫瘍におけるPTHLH遺伝子の発現解析:PTHLHは淡明細胞型腎癌に特異的な発現・予後マーカーである2012

    • Author(s)
      矢尾正祐, 村上貴之, 黄エイ, 水野伸彦、佐野太, 渕桂子, 槙山和秀, 中井川昇, 塩井康一, 岸田健, 長嶋洋治, 窪田吉信
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2012-04-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎癌におけるPLTP遺伝子の発現と臨床病理・予後との関係2011

    • Author(s)
      矢尾正祐, 黄エイ, 長嶋洋治, 佐野太, 近藤慶一, 槙山和秀, 中井川昇, 塩井康一, 岸田健, 窪田吉信
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎癌におけるPLTP遺伝子の発現と臨床病理・予後との関係2011

    • Author(s)
      矢尾正祐, 他
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Expression analysis of Phospholipid Transfer Protein in Clear Cell Renal Carcinoma2010

    • Author(s)
      Huang Y, Murakami T, Sano F, Kondo K, Nakaigawa N, Kishida K, Kubota Y, Nagashima Y, Yao M.
    • Organizer
      第69回日本癌学会総会(英文)
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝子発現からみた腎癌の新たな分類2010

    • Author(s)
      矢尾正祐
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市民文化ホール(岩手)(教育講演)
    • Year and Date
      2010-04-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 遺伝子発現からみた腎癌の新たな分類2010

    • Author(s)
      矢尾正祐
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市、盛岡市民文化ホール(招待講演)
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転移性腎癌治療:病理組織型、遺伝子型からの俯瞰2009

    • Author(s)
      矢尾正祐、蓮見壽史、村上貴之、槇山和秀、近藤慶一、中井川昇、長嶋洋治、窪田吉信
    • Organizer
      第47回日本癌治療学会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川)(ワークショップ)
    • Year and Date
      2009-10-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 淡明細胞腎癌の予後と相関する発現遺伝子群の同定と予後予測スコアモデルの作成2009

    • Author(s)
      黄エイ, 村上貴之, 佐野太, 近藤慶一, 中井川昇, 岸田健, 窪田吉信, 長嶋洋治, 矢尾正祐
    • Organizer
      第68回日本癌学会総会(英文)
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2009-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎癌におけるAquapolin 1遺伝子発現とその診断有用性、臨床応用についての検討2009

    • Author(s)
      矢尾正祐, 黄エイ, 村上貴之, 佐野太, 近藤慶一, 中井川昇, 岸田健, 長嶋洋治, 窪田吉信
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2009-04-17
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎癌における Aquapolin 1遺伝子発現とその診断有用性、臨床応用についての検討2009

    • Author(s)
      矢尾正祐, 他
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2017-10-13  

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