Pathological and prognostic diagnosis of renal cell carcinoma related gene and protein analysis for order made (personalized) medicine.

• Project/Area Number: 21592058
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Iwate Medical University
• Principal Investigator: SUGIMURA Jun 岩手医科大学, 医学部, 講師 (80306018)
• Project Period (FY): 2009-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 遺伝子解析 / 腎癌 / 蛋白発現 / 後天性腎嚢胞 / 腎細胞がん / 遺伝子 / 免疫染色 / 癌 / 蛋白質

Research Abstract

In this study, we examined immunochemical and genetic analysis with renal cell carcinoma about prognostic or pathological gene selected from previous microarray studies. Especially, it was valuable the analysis of protein expression with clinical information. In addition, we demonstrated immunochemical characteristics of acquired polycystic kidney disease with renal cell cancer using several markers. Although those tumors showed a variety of immunochemical profiles, combined with multiple marker allows the accurate differential diagnosis. Our data combined clinical data will show accurate diagnosis of renal cell carcinoma, prognosis and order made (personalized) medicine.

Research Products

• [Journal Article] Brain-specific an giogenesis inhibitor 1 is a putative fa ctor for inhibition of neovascular form ation in renal cell carcinoma (2011)
  • Author(s): Izutsu T, Konda R, Sugimura J, Iwasaki K, Fujioka T
  • Journal Title: J Urol Volume: 185 Issue: 6 Pages: 2353-2358
  • DOI: 10.1016/j.juro.2011.02.019
  • Peer Reviewed
• [Journal Article] Brain-specific angiogenesis inhibitor 1 is a putative factor for inhibition of neovascular formation in renal cell carcinoma (2011)
  • Author(s): Izutsu T, Konda R, Sugimura J, Iwasaki K, Fujioka T
  • Journal Title: J Urol Volume: 185(6) Pages: 2353-8
  • Peer Reviewed
• [Journal Article] Genomic expression and single-nucl eotide polymorphism profiling discrimin ates chromophobe renal cell carcinoma a nd oncocytoma (2010)
  • Author(s): Tan MH, Wong CF, Tan HL, Yang XJ, Ditlev J, Matsuda D, Khoo SK, Sugimura J, Fujioka T, Furge KA, Kort E, Giraud S, Ferlicot S, Vielh P, Amsellem- Ouazana D, Debré D, Flam T, Thiounn N, Zerbib M, Benoît G, Droupy S, Molinié V, Vieillefond A, Tan PH, Richard S, Teh BT
  • Journal Title: BMC Cancer Volume: 10 Issue: 1 Pages: 196-207
  • DOI: 10.1186/1471-2407-10-196
  • Peer Reviewed
• [Journal Article] Expression of hypoxia-inducible protein 2 in renal c ell carcinoma : A promising candidate fo r molecular targeting therapy (2010)
  • Author(s): Seo T, Konda R, Sugimura J, Iwasaki K, Nakamura Y, Fujioka T
  • Journal Title: ONCOLOGY LETTERS Volume: 1 Pages: 697-701
  • Peer Reviewed
• [Journal Article] Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma (2010)
  • Author(s): Min-Han Tan, Chin Fong Wong, Hwei Ling Tan, Ximing J Yang, Jonathon Ditlev, Daisuke Matsuda, Sok Kean Khoo, Jun Sugimura, Tomoaki Fujioka, Kyle A Furge, Eric Kort, Sophie Giraud, Sophiia Ferlicot, Philippe Vielh, Delphine Amsellem-Ouazana, Bernard Debre, Thierry Flam, Nicolas Thiounn, Marc Zerbib, Gerard Benott, Stephane Droupy, Vincent Molinie, Annick Vieillefond, Puay Hoon Tan, Stephane Richard, Bin Tean Teh
  • Journal Title: BMC Cancer. Volume: 10 Pages: 196-207
  • Peer Reviewed
• [Journal Article] Expression of hypoxia-inducible protein 2 in renal cell carcinoma : A promising candidate for molecular targeting therapy (2010)
  • Author(s): Takashi Seo, Ryuichiro Konda, Jun Sugimura, Kazuhiro Iwasaki, Yusuke Nakamura, Tomoaki Fujioka
  • Journal Title: ONCOLOGY LETTERS Volume: 1 Pages: 697-701
  • Peer Reviewed
• [Journal Article] Microarray gene expression profiling using core biopsies of renal neoplasia (2009)
  • Author(s): Rogers CG, Ditlev JA, Tan MH, Sugimura J, Qian CN, Cooper J, Lane B, Jewett MA, Kahnoski RJ, Kort EJ, Teh BT
  • Journal Title: Am J Transl Res Volume: 1 Pages: 55-61
  • Peer Reviewed
• [Journal Article] Microarray gene expression profiling using core biopsies of renal neoplasia. (2009)
  • Author(s): Rogers CG, Ditlev JA, Tan MH, Sugimura J, Qian CN, Cooper J, Lane B, Jewett MA, Kahnoski RJ, Kort EJ, Teh BT.
  • Journal Title: Am J Transl Res. 1 Pages: 55-61
  • Peer Reviewed
• [Presentation] 当院における維持透析患者の悪性腫瘍に関する検討 (2013)
  • Author(s): 常盤傑, 阿部貴弥, 加藤陽一郎, 岩崎一洋, 高田亮, 小原航, 杉村淳, 大森聡, 丹治進 ,藤岡知昭
  • Organizer: 第51回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2013-10-25
• [Presentation] 後天性嚢胞腎に合併した腎癌における免疫組織学的プロフィール (2013)
  • Author(s): 杉村淳, 近田龍一郎, 小松淳,岩崎一洋, 野澤立,藤島洋介, 藤岡知昭
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2013-04-27
• [Presentation] 後天性嚢胞腎に合併した腎癌における免疫組織学的プロフィール (2013)
  • Author(s): 杉村淳、近田龍一郎、小松淳、岩崎一洋、野沢立、藤島洋介、藤岡知昭
  • Organizer: 日本泌尿器科学会総会
  • Place of Presentation: 札幌市
• [Presentation] 当院における維持透析患者の悪性腫瘍に関する検討 (2013)
  • Author(s): 常盤傑、阿部貴弥、加藤陽一郎、岩崎一洋、高田亮、小原航、杉村淳、大森聡、丹治進、藤岡知昭
  • Organizer: 日本癌治療学会学術総会
  • Place of Presentation: 京都市
• [Presentation] 腎癌を合併した後天性嚢胞腎におけるdisruption of epithelial junction complexes (2009)
  • Author(s): 野澤立,近田龍一郎,杉村淳,小松淳,相馬文彦,大澤泰介,藤岡知昭
  • Organizer: 第74回日本泌尿器科学会東部総会
  • Place of Presentation: 松本
  • Year and Date: 2009-10-30
• [Presentation] 腎癌を合併した後天性嚢胞腎におけるdisruption of epithelial junction complexes (2009)
  • Author(s): 野澤立, 近田龍一郎, 杉村淳, 小松淳, 相馬文彦, 大澤泰介, 藤岡知昭
  • Organizer: 第74回日本泌尿器科学会東部総会
  • Place of Presentation: 長野・松本
  • Year and Date: 2009-10-30
• [Presentation] 後天性腎嚢胞の発生と癌化におけるAKT/mTOR signalとGli 1の関与 (2009)
  • Author(s): 小松淳,近田龍一郎,杉村淳,大澤泰介,常盤傑,兼平貢,相馬文彦,藤岡知昭
  • Organizer: 第97回日本泌尿器科学会総会
  • Place of Presentation: 岡山
  • Year and Date: 2009-04-16