Diagnosis and relapse prediction of prostate cancer by urine biomarkers.
| Project/Area Number |
21592059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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|---|
| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAZAKI Hitomi 獨協医科大学, 医学部・泌尿器科学, 研究技師
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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|---|
| Keywords | 前立腺癌 / 尿中バイオマーカー / 診断予測 / 再発予測 / 補助診断 / PCA3 / FGF / WDR 19 / 再燃予測因子 / トランスレーショナルリサ ーチ / バイオマーカー / 尿検査 / 診断 / 再発再燃 / 予後予測 |
|---|
| Research Abstract |
Urine samples were obtained from the patients who needed prostate biopsy following a digital rectal exam (DRE) before either biopsy. After isolation of RNA from each sample, quantitative RT-PCR was performed to detect 14 prostate cancer biomarkers. The amount of PCR product was estimated by delta Ct method. The delta Ct value was normalized against urine PSA expression and was used as urine biomarker value. We found that the underexpression of FGF7 was useful for a prostate cancer detection particularly to exceed PCA3 in the gray zone (serum PSA<10ng/ml), but the significant difference was not found. In the prostate cancer cases that endocrine therapy was provided, the likelihood that WDR19 underexpression characteristics could become the relapse predictor was shown.
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Report
(6 results)
Research Products
(46 results)
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[Journal Article] Metronomic Oral Cyclophosphamide Chemotherapy Possibly Contributes to Stabilization of Disease in Patients With Metastatic Castration-Resistant Prostate Cancer : A Prospective Analysis of Consecutive Cases2014
Author(s)
Yashi M, Nishihara D, Mizuno T, Yuki H, Masuda A, Kambara T, Betsunoh H, Abe H, Fukabori Y, Muraishi O, Kamai T
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Journal Title
Clin Genitourin Cancer
Volume: (印刷中)
Issue: 5
Pages: e197-e203
DOI
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Peer Reviewed
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[Presentation] FGF7 as a candidate urine biomarker for prostate cancer detection2014
Author(s)
Y. Fukabori, H. Yamazaki, A. Yanagibayashi, M. Yashi, H. Abe, H. Betsunoh, A. Masuda, H. Yuki, K. Arai, T. Kamai
Organizer
29th Annual Congress of the European Association of Urology
Place of Presentation
Stockholm, Sweden
Year and Date
2014-04-12
Related Report
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[Presentation] FGF7 as a candidate urine biomarker for prostate cancer detection2014
Author(s)
Fukabori Y., Yamazaki H., Yanagibayashi A., Yashi M., Abe H., Betsunoh H., Masuda A., Yuki H., Arai K., Kamai T.
Organizer
The 29th EAU Annual Congress
Place of Presentation
Stockholm, Sweden
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