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Contribution of acid-sensing nociceptor molecules (ASIC and TRPV1) to symptom onset in interstitial cystitis

Research Project

Project/Area Number 21592068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionShiga University of Medical Science (2010-2011)
University of Yamanashi (2009)

Principal Investigator

ARAKI Isao  滋賀医科大学, 医学部, 准教授 (50252424)

Co-Investigator(Kenkyū-buntansha) 小林 英樹  山梨大学, 大学院・医学工学総合研究部, 助教 (50402053)
芳山 充晴  山梨大学, 大学院・医学工学総合研究部, 医学研究員 (20422694)
武田 正之  山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)
Co-Investigator(Renkei-kenkyūsha) TAKEDA Masayuki  山梨大学, 大学院・医学工学総合研究部, 教授 (80197318)
KOBAYASHI Hideki  山梨大学, 医学部付属病院, 助教 (50402053)
YOSHIYAMA Mitsuharu  山梨大学, 医学部, 非常勤講師 (20422694)
MOCHIZUKI Tsutomu  山梨大学, 医学部付属病院, 助教 (50377496)
TSURU Teruhiko  滋賀医科大学, 医学部, 助教 (90625675)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords膀胱上皮 / イオンチャネル / 知覚 / 痛み / 炎症 / 排尿 / イオンチャンネル / 膀胱 / 膀胱炎 / 酸 / 上皮 / 間質性膀胱炎
Research Abstract

The study elucidated the localization of acid-sensing ion channels (ASICs) in the bladder. The sex-related differences in expression profile of ASIC and in bladder response to intravesical acid irritation indicated that ASICs may contribute to the symptom onset in interstitial cystitis preferably occurring in women by controlling acid sensitivity in the bladder sensory pathway.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (68 results)

All 2012 2011 2010 2009 Other

All Journal Article (27 results) (of which Peer Reviewed: 23 results) Presentation (27 results) (of which Invited: 6 results) Book (12 results) Remarks (2 results)

  • [Journal Article] Intraoperative fluoroscopic monitoring during TVM surgery: safer procedure even for beginners.2012

    • Author(s)
      Kobayashi H, Sawada N, Kira S, Miyamoto T, Haneda Y, Zakoji H, Tsuchida T, Araki I, Takeda M
    • Journal Title

      Open Journal of Urology

      Volume: 2 Issue: 02 Pages: 72-74

    • DOI

      10.4236/oju.2012.22012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 8.今後期待されれる治療薬の候補 特集「過活動膀胱診療を考える」2012

    • Author(s)
      荒木勇雄,水流輝彦
    • Journal Title

      Progress in Medicine

      Volume: 32 Pages: 879-882

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 総説2.高齢者における頻尿,尿失禁の病態と診断 特集「高齢者の頻尿と尿失禁」2012

    • Author(s)
      荒木勇雄,水流輝彦,吉田哲也,影山進
    • Journal Title

      Geriatric Medicine(老年医学)

      Volume: 50 Pages: 551-554

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 3. 排尿困難・尿閉をきたす薬剤 特集:薬剤投与と泌尿器科的副作用-泌尿器科医の必須知識2012

    • Author(s)
      荒木勇雄,水流輝彦,影山進,岡田裕作
    • Journal Title

      臨床泌尿器科

      Volume: 66 Pages: 561-565

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Decreased expression of the epithelial Ca2+ channel TRPV5 and TRPV6 in human renal cell carcinoma ssociated with vitamin D receptor2011

    • Author(s)
      Wu Y, Miyamoto T, Li K, Nakagomi H, Sawada N, Kira S, Kobayashi H, Zakohji H, Tsuchida T, Fukazawa M, raki I, Takeda M
    • Journal Title

      J Urol

      Volume: 186(6) Issue: 6 Pages: 2419-2425

    • DOI

      10.1016/j.juro.2011.07.086

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bladder outlet obstruction induced expression of prostaglandin E2receptor subtype EP4 in the rat urinary bladder: a possible counteractive mechanism against detrusor overactivity2011

    • Author(s)
      Beppu M, Araki I, Yoshiyama M, Du S, Kobayashi H, Zakoji H, Takeda M
    • Journal Title

      J Urol

      Volume: 186(6) Issue: 6 Pages: 2463-2469

    • DOI

      10.1016/j.juro.2011.07.087

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard2011

    • Author(s)
      Yoshida A, Seki M, Nasrin S, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Ehlert FJ, Yamada S
    • Journal Title

      Urology

      Volume: 78(3) Issue: 3 Pages: 721.e7-721.e12

    • DOI

      10.1016/j.urology.2011.05.011

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Muscarinic receptor binding of imidafenacin in the human bladder mucosa and detrusor and parotid gland2011

    • Author(s)
      Seki M, Ogoda M, Kuraoka S, Otsuka A, Ozono S, Takeda M, Masuyama K, Araki I, Yamada S
    • Journal Title

      LUTS: Lower Urinary Tract Symptoms

      Volume: 3(2) Issue: 2 Pages: 64-68

    • DOI

      10.1111/j.1757-5672.2011.00089.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Japanese Naftopidil Neurogenic Lower Urinary Tract Dysfunction Study Group: Predictive factors for the effect of alpha1-D/A adrenoceptor antagonist, naftopidil, on subjective and objective parameters in patients with neurogenic lower urinary tract dysfunction2011

    • Author(s)
      Takeda M, Homma Y, Araki I, Kakizaki H, Yamani shi T, Yokota T, Gotoh M, Igawa Y, Seki N, Takei M, oshida M, Sugaya K, Nishizawa O
    • Journal Title

      BJU Int

      Volume: 108(1) Issue: 1 Pages: 100-107

    • DOI

      10.1111/j.1464-410x.2010.09682.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 排尿障害(下部尿路機能障害)に対する薬物療法 特集「排尿障害-最新診療動向」2011

    • Author(s)
      荒木勇雄
    • Journal Title

      医学のあゆみ

      Volume: 238 Pages: 329-334

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid: in-vivo evaluations on the sex difference in decerebrate unanesthetized mice2010

    • Author(s)
      Yoshiyama M, Araki I, Kobayashi H, Zakoji H, Takeda M
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 298 Issue: 6 Pages: F1351-F1359

    • DOI

      10.1152/ajprenal.00695.2009

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensor mechanism and afferent signal transduction of the urinary bladder: special focus on TRP ion channels2010

    • Author(s)
      Takeda M, Mochizuki T, Yoshiyama M, Nakagomi H, Kobayashi H, Sawada N, Zakoji H, Du S, Araki I
    • Journal Title

      LUTS: Lower Urinary Tract Symptoms

      Volume: 2(2) Issue: 2 Pages: 51-60

    • DOI

      10.1111/j.1757-5672.2010.00074.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Emerging families of ion channel involved in urinary bladder nociception2010

    • Author(s)
      Araki I, Yoshiyama M, Kobayashi H, Mochizuki M, Du S, Okada Y, Takeda M
    • Journal Title

      Pharmaceuticals

      Volume: 3(7) Issue: 7 Pages: 2248-2267

    • DOI

      10.3390/ph3072248

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical guidelines for nocturia2010

    • Author(s)
      Nishizawa O, Araki I, Ishizuka O, Uchimura N, Oh-oka H, Ozono S, Kakizaki H, Kasahara M, Gotoh M, Sakakibara R, Shinbo H, Sugaya K, Suzuki Y, Sone A, Takei M, Takeda M, Hirayama A, Homma Y, Yamaguchi O, Yamani shi T, Yo ko yama O, Yoshida M
    • Journal Title

      Int J Urol

      Volume: 17(5) Issue: 5 Pages: 379-409

    • DOI

      10.1111/j.1442-2042.2010.02527.x

    • NAID

      10027258151

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Pathophysiology of Voiding Dysfunction and Pharmacological Therapy2010

    • Author(s)
      Takeda M, Araki I, Mochizuki T, Nakagomi H, Kobayashi H, Sawada N, Zakoji H
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 112 Issue: 2 Pages: 121-127

    • DOI

      10.1254/jphs.09R17FM

    • NAID

      10029888469

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional roles of TRPV1 channels in lower urinary tract irritated by acetic acid : in-vivo evaluations on the sex difference in decerebrate unanesthetized mice.2010

    • Author(s)
      Yoshiyama M, Araki I, Kobayashi H, Zakoji H, Takeda M
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 298

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Emerging families of ion channel involved in urinary bladder nociception.2010

    • Author(s)
      Araki I, Yoshiyama M, Kobayashi H, Mochizuki M, Du S, Okada Y, Takeda M
    • Journal Title

      Pharmaceuticals

      Volume: 3 Pages: 2248-2267

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical guidelines for nocturia.2010

    • Author(s)
      Nishizawa O, Araki I, Ishizuka O, Uchimura N, Oh-oka H, Ozono S, Kakizaki H, Kasahara M, Gotoh M, Sakakibara R, Shinbo H, Sugaya K, Suzuki Y, Sone A, Takei M, Takeda M, Hirayama A, Homma Y, Yamaguchi O, Yamanishi T, Yokoyama O, Yoshida M
    • Journal Title

      Int J Urol

      Volume: 17 Pages: 379-409

    • NAID

      10027258151

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in expression profile of acid-sensing ion channels in the mouse urinary bladder: a possible involvement in irritative bladder symptoms2009

    • Author(s)
      Kobayashi H, Yoshiyama M, Zakoji H, Takeda M, Araki I
    • Journal Title

      BJU Int

      Volume: 104(11) Issue: 11 Pages: 1746-1751

    • DOI

      10.1111/j.1464-410x.2009.08658.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incontinence and detrusor dysfunction associated with pelvic organ prolapse: clinical value of preoperative urodynamic evaluation2009

    • Author(s)
      Araki I, Haneda Y, Mikami Y, Takeda M
    • Journal Title

      Int Urogynecol J Pelvic Floor Dysfunct

      Volume: 20(11) Issue: 11 Pages: 1301-1306

    • DOI

      10.1007/s00192-009-0954-2

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca2+influx and ATP release in primary urothelial cell cultures2009

    • Author(s)
      Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, Koizumi S, Takeda M, Tominaga M
    • Journal Title

      J Biol Chem

      Volume: 284(32) Issue: 32 Pages: 21257-21264

    • DOI

      10.1074/jbc.m109.020206

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of NF-κB by cyclosporine A and tacrolimus (FK506) via induction of the C/EBP family: Implication for unfolded protein response2009

    • Author(s)
      Du S, Hiramatsu N, Hayakawa K, Kasai A, Okamura M, Huang T, Yao J, Takeda M, Araki I, Sawada N, Paton AW, Paton JC, and KitamuraM
    • Journal Title

      J Immunol

      Volume: 182 Issue: 11 Pages: 7201-7211

    • DOI

      10.4049/jimmunol.0801772

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical guideline for male lower urinary tract symptoms2009

    • Author(s)
      Homma Y, Araki I, Igawa Y, Ozono S, Gotoh M, Yamanishi T, Yokoyama O, Yoshida M
    • Journal Title

      Int J Urol

      Volume: 16(10) Issue: 10 Pages: 775-790

    • DOI

      10.1111/j.1442-2042.2009.02369.x

    • NAID

      10025617982

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanosensitive ion channels in bladder sensory transduction2009

    • Author(s)
      Araki I, Du S, Kobayashi H, Yoshiyama M, Takeda M
    • Journal Title

      LUTS: Lower Urinary Tract Symptoms

      Volume: 1(Suppl 1) Issue: s1

    • DOI

      10.1111/j.1757-5672.2009.00021.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The TRPV4 cation channel mediates stretch-evoked Ca^<2+> influx and ATP release in primary urothelial cell cultrues.2009

    • Author(s)
      Mochizuki T
    • Journal Title

      J Biol Chem 284

      Pages: 21257-21264

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incontinence and detrusor dysfunction associated with pelvic organ prolapse : clinical value of preoperative urodynamic evaluation.2009

    • Author(s)
      Araki I
    • Journal Title

      Int Urogynecol J Pelvic Floor Dysfunct 20

      Pages: 1301-1306

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in expression profile of acid-sensing ion channels in the mouse urinary bladder : a possible involvement in irritative bladder symptoms.2009

    • Author(s)
      Kobayashi H
    • Journal Title

      BJU Int 104

      Pages: 1746-1751

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 特別講演「蓄尿はどのようにして知覚されるのか?膀胱上皮と機械感受性イオンチャネルの役割」2012

    • Author(s)
      荒木勇雄
    • Organizer
      愛宕GUフォーラム
    • Place of Presentation
      東京(慈恵医大)
    • Year and Date
      2012-03-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 特別講演「女性の下部尿路機能障害2012

    • Author(s)
      荒木勇雄
    • Organizer
      愛知県泌尿器科医会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 臨床からみた排尿筋低活動へのアプローチ.教育セミナー3-12「排尿筋低活動の治療をどう考える?」2012

    • Author(s)
      荒木勇雄
    • Organizer
      第100回日本泌尿器科学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 特別講演「女性の下部尿路機能障害」2012

    • Author(s)
      荒木勇雄
    • Organizer
      愛知県泌尿器科医会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 特別講演「蓄尿はどのようにして知覚されるのか?膀胱上皮と機械感受性イオンチャネルの役割」2012

    • Author(s)
      荒木勇雄
    • Organizer
      愛宕GUフォーラム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 臨床からみた排尿筋低活動へのアプローチ2012

    • Author(s)
      荒木勇雄
    • Organizer
      第100回日本泌尿器科学会総会 教育セミナー3-12「排尿筋低活動の治療をどう考える?」
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] The functional role of EP4 receptors in the rat urinary bladder with outlet obstruction.2012

    • Author(s)
      Zakoji H, Beppu M, Kobayashi H, Yoshiyama M, Takeda M, Araki I:
    • Organizer
      European Association of Urology 27th Annual Congress, Paris, France
    • Place of Presentation
      パリ
    • Related Report
      2011 Annual Research Report
  • [Presentation] 過活動膀胱治療における抗コリン薬交替療法の有用性についての検討:副作用に不満を持つ患者でのトルテロジンへの変薬効果2012

    • Author(s)
      水流輝彦,荒木勇雄,前澤卓也,花田英紀,影山進,岡田裕作
    • Organizer
      第19回日本排尿機能学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 過活動膀胱診療ガイドライン-診断の実践と問題点-.イブニングシンポジウム「過活動膀胱診療ガイドライン 改訂ダイジェスト版,間質性膀胱炎診療ガイドライン」2011

    • Author(s)
      荒木勇雄
    • Organizer
      第61回日本泌尿器科学会中部総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] Mechanosensitive ion channels in bladder mechanosensation. イブニングセミナー1「尿路上皮を科学する-膀胱壁におけるシグナル伝達と過活動膀胱の尿中マーカーの探索-」2011

    • Author(s)
      荒木勇雄
    • Organizer
      第18回日本排尿機能学会
    • Place of Presentation
      福井
    • Related Report
      2011 Final Research Report
  • [Presentation] 膀胱知覚情報伝達システムにおける機械感受性イオンチャネルの役割2011

    • Author(s)
      荒木勇雄
    • Organizer
      第99回日本泌尿器科学会総会 サテライトセミナー「「蓄尿症状」膀胱蓄尿症状をつかさどる分子メカニズム 解き明かされる蓄尿機能 基礎から臨床」
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Mechanosensitive ion channels in bladder mechanosensation.2011

    • Author(s)
      荒木勇雄
    • Organizer
      第18回日本排尿機能学会 イブニングセミナー1「尿路上皮を科学する-膀胱壁におけるシグナル伝達と過活動膀胱の尿中マーカーの探索-
    • Place of Presentation
      福井
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 過活動膀胱診療ガイドライン-診断の実践と問題点-2011

    • Author(s)
      荒木勇雄
    • Organizer
      第61回日本泌尿器科学会中部総会  イブニングシンポジウム「過活動膀胱診療ガイドライン 改訂ダイジェスト版,間質性膀胱炎診療ガイドライン」
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 尿路上皮のENaC/TRPVチャネル2010

    • Author(s)
      荒木勇雄
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      甲府(招待講演)
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膀胱知覚情報伝達システムにおける機械感受性イオンチャネルの役割.サテライトセミナー「「蓄尿症状」膀胱蓄尿症状をつかさどる分子メカニズム 解き明かされる蓄尿機能 基礎から臨床」2010

    • Author(s)
      荒木勇雄
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿路上皮のENaC/TRPVチャネル.シンポジウム1「下部尿路機能障害の薬物療法-現状と展望」2010

    • Author(s)
      荒木勇雄
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      甲府
    • Related Report
      2011 Final Research Report
  • [Presentation] 私の下部尿路機能研究の歴史.オープニングセミナー「下部尿路機能研究:私の歴史」2010

    • Author(s)
      荒木勇雄
    • Organizer
      第17回日本排尿機能学会
    • Place of Presentation
      甲府
    • Related Report
      2011 Final Research Report
  • [Presentation] OAB治療の現状と新規治療ターゲット.シンポジウム:過活動膀胱(OAB)の基礎と臨床2010

    • Author(s)
      荒木勇雄
    • Organizer
      第52回日本平滑筋学会総会
    • Place of Presentation
      仙台
    • Related Report
      2011 Final Research Report
  • [Presentation] 膀胱のメカノセンサー2010

    • Author(s)
      荒木勇雄
    • Organizer
      第12回UTPシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Gene expression patterns of acid-sensing ion channels (ASICs) families in mammalian bladder2010

    • Author(s)
      Kobayashi H, Yoshiyama M, Inuzuka H, Kira S, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Zakoji H, Tsuchida T, Araki I, Takeda M
    • Organizer
      International Continence Society 40th Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Intravesical infusion of a non-amiloride blocker of acid-sensing ion channels fails to affect lower urinary tract activity in unanesthetized decerebrate mice2010

    • Author(s)
      Yoshiyama M, Araki I, Kobayashi H, Zakoji H, Takeda M
    • Organizer
      International Continence Society 40th Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures using original culture cell stretch system2010

    • Author(s)
      Mochizuki T, Nakagomi H, Miyamoto T, Araki I, Yoshiyama M, Takeda M
    • Organizer
      American Urological Association 105th annual meeting, San Francisco
    • Place of Presentation
      CA, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Sex difference in expression profiles of acid-sensing ion channels and transient receptor potential channel v1 in the mouse urinary bladder2010

    • Author(s)
      Kobayashi H, Yoshiyama M, Araki I, Kira S, Inuzuka H, Nakagomi H, Miyamoto T, Haneda Y, Sawada N, Kamiyama M, Kudou S, Zakoji H, Tsuchida T, Fukasawa M, Takeda M
    • Organizer
      European Association of Urology 25th Annual Congress
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Effect of intravesical infusion of capsazepine, a TRPV1 blocker, on activity of the lower urinary tract irritated by acetic acid in unanesthetized decerebrate mice2009

    • Author(s)
      Yoshiyama M, Kobayashi H, Araki I, Zakoji H, Takeda M
    • Organizer
      International Continence Society 39th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Sex difference in expression profile of acid-sensing ion channels and transient receptor potential channel V1 in the mouse urinary bladder2009

    • Author(s)
      Kobayashi H, Yoshiyama M, Araki I, Sawada N, Mochizuki T, Zakoji H, Takeda M
    • Organizer
      International Continence Society 39th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The expression of transient receptor potential (TRP) V4, A1 and V1 in the human bladder mucosa of normal and bladder outlet obstruction: a novel mechanism in the obstruction-induced bladder overactivity2009

    • Author(s)
      Miyamoto T, Mochizuki T, Zakoji H, Kobayashi H, Yoshiyama M, Araki I, Takeda M
    • Organizer
      International Continence Society 39th Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] The effect of chinese herbal medicine containing aconitine on the pain relief in interstitial cystitis patients- a preliminary study2009

    • Author(s)
      Tsuchi da T, Mi yamoto T, Yamagi shi T, Kira S, Kayanuma K, Haneda Y, Kobayashi H, Zakoji H, Araki I, Takeda M
    • Organizer
      American Urological Association 104th annual meeting
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2011 Final Research Report
  • [Book] 「腎疾患治療マニュアル2012-13」腎と透析 第72巻2012臨時増刊号『腎と透析』下部尿路症状(Lower Urinary Tract Symptoms).治療各論:泌尿器科疾患2012

    • Author(s)
      荒木勇雄,水流輝彦
    • Total Pages
      753
    • Publisher
      東京医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 「患者説明にそのまま使える!よくわかる泌尿器科検査の知識」泌尿器ケア第198巻 2012年夏季増刊第3章-7 腹圧下漏出時圧測定2012

    • Author(s)
      水流輝彦,松本綾,荒木勇雄
    • Total Pages
      452
    • Publisher
      メディカ出版
    • Related Report
      2011 Annual Research Report
  • [Book] TRP channels in urinary bladder mechanosensation. In: Advances in Experimental Medicine & Biology, vol. 704, The Transient Receptor Potential Channel2011

    • Author(s)
      Md. Shahidul Islam (ed.), Springe
    • Publisher
      Dordrecht
    • Related Report
      2011 Final Research Report
  • [Book] 総合臨床2011

    • Author(s)
      荒木勇雄,岡田裕作
    • Related Report
      2011 Final Research Report
  • [Book] The Transient Receptor Potential Channel In: Advances in Experimental Medicine & Biology, vol. 704; Md. Shahidul Islam (ed.)2011

    • Author(s)
      Isao Araki
    • Total Pages
      1095
    • Publisher
      Springer, Dordrecht
    • Related Report
      2011 Annual Research Report
  • [Book] 「泌尿器科診療ガイド」尿道狭窄.第8章 尿道2011

    • Author(s)
      荒木勇雄
    • Total Pages
      471
    • Publisher
      金芳堂
    • Related Report
      2011 Annual Research Report
  • [Book] 総合臨床 日常診療でよくみる症状・病態-診断の指針・治療の指針-.XI.腎臓および泌尿器系の異常.排尿障害・排尿痛2011

    • Author(s)
      荒木勇雄,岡田裕作
    • Total Pages
      484
    • Publisher
      永井書店
    • Related Report
      2011 Annual Research Report
  • [Book] The Transient Receptor Potential Channel2011

    • Author(s)
      Isao Araki
    • Total Pages
      1095
    • Publisher
      Springer
    • Related Report
      2010 Annual Research Report
  • [Book] 過活動膀胱(泌尿器・男性性器疾患)「今日の診断指針」第6版2010

    • Author(s)
      金沢一郎,永井良三 総編集
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] II.夜間頻尿の治療.第1章 夜間頻尿の診断と治療.「日本泌尿器科学会 2009年卒後教育テキスト」(第14巻2号)2009

    • Author(s)
      内藤誠二編集
    • Publisher
      日本泌尿器科学会
    • Related Report
      2011 Final Research Report
  • [Book] EBM泌尿器科疾患の治療2009-20102009

    • Author(s)
      後藤百万,小川修,筧善行,出口隆,鈴木孝治編集
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] EBM泌尿器科疾患の治療 2009-20102009

    • Author(s)
      荒木勇雄
    • Total Pages
      563
    • Publisher
      中外医学社
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://sumsuro.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks] URL:

    • URL

      http://www.uro-yamanashi.com/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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