Implantation of autologous bone marrow cells has a potential to be treatments for radiotherapy-induced bladder dysfunction
Project/Area Number |
21592069
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Shinshu University |
Principal Investigator |
KATO Haruaki 信州大学, 医学部・附属病院, 講師 (90233808)
|
Research Collaborator |
IMAMURA Tetsuya 信州大学, 医学部, 助教 (00467143)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 再生医療 / 放射線照射療法 / 排尿障害 / 骨髄由来細胞 / 放射線治療 / 膀胱 / 平滑筋層 / 神経線維 / ラット / 自己骨髄由来細胞 / 放射線照射傷害 / 膀胱機能障害 / フラッシュアウト法 / 細胞培養 |
Research Abstract |
We determined if implantation of bone marrow-derived cells has a potential to be treatments for radiotherapy-induced bladder dysfunction. The cell implantation reconstructed smooth muscle layers and nerve fibers. The cell-implanted urinary bladders recovered regular voiding intervals and low residual volume, which were similar to non-irradiated normal bladder function.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Loss-of-function mutations of CHST14 in a new type of Ehlers-Danlos syndrome2010
Author(s)
Miyake N, Kosho T, Mizumoto S, Furuichi T, Hatamochi A, Nagashima Y, Arai E, Takahashi K, Kawamura R, Wakui K, Takahashi J, Kato H, Yasui H, Ishida T, Ohashi H, Nishimura G, Shiina M, Saitsu H, Tsurusaki Y, Doi H, Fukushima Y, Ikegawa S, Yamada S, Sugahar
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Journal Title
Hum Mutat
Volume: 31
Issue: 6
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Presentation] 膀胱・尿道損傷2010
Author(s)
加藤晴朗
Organizer
第98回日本泌尿器科学会総会(卒後教育講演)
Place of Presentation
盛岡市
Year and Date
2010-04-30
Related Report
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