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The research on the usefulness of stem cells derrived adipose tissue for reconering renal funcion after partail nephrectomy

Research Project

Project/Area Number 21592071
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagoya University

Principal Investigator

SASSA Naoto  名古屋大学, 医学部附属病院, 助教 (50437026)

Co-Investigator(Kenkyū-buntansha) HATTORI Ryohei  名古屋大学, 医学系研究科, 准教授 (20324410)
YAMAMOTO Tokunori  名古屋大学, 医学部附属病院, 講師 (20182636)
舟橋 康人  名古屋大学, 医学部附属病院, 病院助教 (70534824)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords脂肪由来幹細胞 / 腎部分切除術 / 尿細管周囲毛細血管血流 / 時空間画像処理 / 腎部分切除後の腎機能回復 / 尿路管周囲毛細血管血流 / 脂肪脂肪由来幹細胞 / 腹腔鏡手術 / 気腹圧 / 腎微小循環
Research Abstract

Background.
Acute renal ischemic injury(AKI) represents a major clinical problem with renal arterial clamp at parial nephrectony. The use of therapy using adipose tissue-derived stem cells(ASCs) has been suggested as a potential modality to attenutate the ischemic renal damage. Methods. We investigated the possible renoprotection of pretreatment of ASCs before and after in a rat ischemia. reperfusion(I. R) model of AKI. Twenty-four hours postischemia, blood flow in peritubular capillaries(PTC) was measured using intravital videomicroscopy.
Results.
We demonstrated that ADRC therapy significantly reduced serum creatinine and BUN. Histological analysis further validated a significantly attenuated tubular damage. Intravital videomicroscopy and measurement of red blood cell velocity in peritubular capillaries showed ASCs-injected kidneys displayed significant hemodynamic improvement.
Conclusions.
The subscapular administration of ASCs to the kidney attenuates I/R renal injury though antiinflammation, antiapotoyic effect and peritubular capillary microcirculation. The present study suggests that ASCs would be a useful tool in preventing ishemic kidney damage in the clinical setting.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 8 results) Presentation (11 results)

  • [Journal Article] Low serum cultured adipose tissue-derived stromal cells ameliorate acute kidney injury in rats2012

    • Author(s)
      Katsuno T, Ozaki T, Furuhashi K, Kim H, Yasuda K, Yamamoto T, Sato W, Tsuboi N, Mizuno M, Ito Y, Imai E, Matsuo S, Matuyama S
    • Journal Title

      Cell Transplantation

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress uri nary incontinence2012

    • Author(s)
      Yamamoto T, Gotoh M, Kato M, Majima T, Toriyama T, Kamei Y, Iwaguro H, Mastukawa Y, Funahashi Y
    • Journal Title

      J Urol

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of warm ischemia on renal function during partial nephrectomy : assessment with new 99mTc-mercaptoacet yltriglycine scintigra phyparameter2012

    • Author(s)
      Funahashi Y, Hattori R, Yamamoto T, Sassa N, Fujita T, Gotoh M
    • Journal Title

      Urology

      Volume: 79(1) Pages: 160-4

    • Related Report
      2011 Final Research Report
  • [Journal Article] Subclassification of pT3 Urothelial Carcinoma of the Renal Pelvicalyceal System is Associated With Recurrence-Free and Cancer-Specific Survival : Proposal for a Revision of the Current TNM Classification2012

    • Author(s)
      Tsuzuki T, Sassa N, Gotoh M Re : Yann Neuzillet, Xavier Tillou, Re : Shahrokh F. Shariat, Richard Zigeuner, Michael Rink
    • Journal Title

      Eur Urol

      Volume: (In press) Pages: 23-23

    • Related Report
      2011 Final Research Report
  • [Journal Article] Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence : report of 3 initial cases2012

    • Author(s)
      Yamamoto T, Gotoh M, Kato M, Majima T, Toriyama T, Kamei Y, Iwaguro H, Mastukawa Y, Funahashi Y
    • Journal Title

      Int J Urol.

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal cell carcinoma(RCC) in patients with end-stage renal disease ex hibits many favourable clinical, patholo gic, and outcome features compared with RCC in the general population2011

    • Author(s)
      Tsuzuki T, Sassa N, Gotoh M. Re : Yann N euzillet, Xavier Tillou, Romain Mathieu, et al.
    • Journal Title

      Eur Uro

      Volume: 60(4) Pages: 35-36

    • Related Report
      2011 Final Research Report
  • [Journal Article] The post-operative pathological prognostic parameters of clear cell renal cell carcinoma in pT1a cases2011

    • Author(s)
      Nishikimi T, Tsuzuki T, Fujita T, Sassa N, Fukatsu A, Katsuno S, Yoshino Y, Hattori R, Gotoh M
    • Journal Title

      Pathol Int

      Volume: 61(3) Pages: 116-21

    • NAID

      10031185059

    • Related Report
      2011 Final Research Report
  • [Journal Article] Renal cell carcinomas in haemodialysis patients : does haemodialysis duration influence pathological cell types and prognosis2011

    • Author(s)
      Sassa N, Hattori R, Tsuzuki T, Watarai Y, Fukatsu A, Katsuno S, Nishikimi T, Fujita T, Ohmae K, Gotoh M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(5) Pages: 1677-82

    • Related Report
      2011 Final Research Report
  • [Journal Article] Re : Yann Neuzillet, Xavier Tillou, Romain Mathieu, et al.Renal cell carcinoma (RCC) in patients with end-stage renal disease exhibits many favourable clinical, pathologic, and outcome features compared with RCC in the general population2011

    • Author(s)
      Tsuzuki T, Sassa N, Gotoh M.
    • Journal Title

      Eur Urol.

      Volume: 60(4)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The post-operative pathological prognostic parameters of clear cell renal cell carcinoma in pT1a cases2011

    • Author(s)
      Nishikimi T, Tsuzuki T, Fujita T, Sassa N, Fukatsu A, Katsuno S, Yoshino Y, Hattori R, Gotoh M
    • Journal Title

      Pathol Int.

      Volume: 61(3) Pages: 116-21

    • NAID

      10031185059

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between renal parenchymal volume and single kidney glomerular filtration rate before and after unilateral nephrectomy2011

    • Author(s)
      Funahashi Y, Hattori R, Yamamoto T, Kamihira O, Sassa N, Gotoh M
    • Journal Title

      Urology

      Volume: 77(6) Pages: 1404-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal cell carcinomas in haemodialysis patients : does haemodialysis duration influence pathological cell types and prognosis?2011

    • Author(s)
      Sassa N, Hattori R, Tsuzuki T, Watarai Y, Fukatsu A, Katsuno S, Nishikimi T, Fujita T, Ohmae K, Gotoh M
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26(5) Pages: 1677-82

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical efficacy of a loading dose of naftopidil for patients with benign prostate hyperplasia2011

    • Author(s)
      Funahashi Y, Hattori R, Matsukawa Y, Komatsu T, Sassa N, Gotoh M
    • Journal Title

      World J Urol.

      Volume: 29(2) Pages: 225-3

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo detrusor under activity after laparoscopic radical prostatectomy2010

    • Author(s)
      Matsukawa Y, Hattori R, Komatsu T, Funahashi Y, Sassa N, Gotoh M
    • Journal Title

      Int J Urol

      Volume: 17(7) Pages: 643-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of warm ischemia on renal function during partial nephrectomy : asse ssment with new 99mTc-mercaptoace tyltriglycine scintigraphy parameter2010

    • Author(s)
      Funahashi Y, Hattori R, Yamamoto T, Sassa N, Fujita T
    • Journal Title

      Urology

      Volume: 79(1) Pages: 60-64

    • Related Report
      2011 Final Research Report
  • [Journal Article] Renal cell carcinomas in haemodialysis patients : does haemodialysis duration influence pathological cell types and prognosis?2010

    • Author(s)
      N.Sasa, R.Hattori, T.Tsuzuki, Y.Watarai, A.Fukatsu, S.Katsuno, T.Nishikimi, T.Fujita, K.Ohmae, M.Gotoh.
    • Journal Title

      Nephrol Dial Transplant

      Volume: 73(2) Pages: 1677-1682

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct visualization of renal hemodynamics affected by carbon dioxide-induced pneumoperitoneum2009

    • Author(s)
      Sassa N, Hattori R, Yamamoto T, Kato M, Komatsu T, Matsukawa Y, Funahashi Y, Gotoh M
    • Journal Title

      Urology

      Volume: 73(2) Pages: 311-5

    • Related Report
      2011 Final Research Report
  • [Journal Article] Direct visualization of renal hemodynamics affected by carbon-dioxide in duced pneumoperitoneum2009

    • Author(s)
      N.Sassa, R.Hattori, T.Yamamoto, M.Kato, T.Komatsu, Y.Matsukawa, Y.Funahashi, M.Gotoh
    • Journal Title

      Urology 73(2)

      Pages: 311-315

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 名古屋大学関連施設における尿管腫瘍の予後因子の検討2011

    • Author(s)
      佐々直人
    • Organizer
      第99回日本泌尿器科学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 名古屋大学におけるmRCCに対する分子標的剤治療成績2011

    • Author(s)
      佐々直人
    • Organizer
      第49回日本癌治療学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿路上皮癌に対する11C-choline PET-CTの有用性の検討2010

    • Author(s)
      佐々直人、山本徳則、服部良平、後藤百万、加藤克彦
    • Organizer
      第48回日本癌治療学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 全国のクリニカルパス研究における、経尿道的前立腺手術の患者満足度調査2010

    • Author(s)
      佐々直人、荒井陽一、川喜田睦司、津島知靖、内藤誠二、野尻佳克、長谷川友紀、服部良平、松田公志、岡村菊夫
    • Organizer
      第24回日本Endourology・ESWL学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎孟癌におけるstagingを中心とした病理組織学的再検討~pT3は本当に臨床予後を反映しているか?~2010

    • Author(s)
      佐々直人、都築豊徳、小林弘明、深津顕俊、木村亨、馬嶋剛、服部良平、後藤百万
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-04-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎盂癌におけるstagingを中心とした病理組織学的再検討2010

    • Author(s)
      佐々直人
    • Organizer
      第98回日本泌尿器科学会総会
    • Place of Presentation
      岩手
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿路上皮癌に対する111C-choline-PETの有用性の検討2010

    • Author(s)
      佐々直人
    • Organizer
      第48回日本癌治療学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 全国のクリニカルパス研究における経尿道的前立腺手術の患者満足度調査2010

    • Author(s)
      佐々直人
    • Organizer
      第24回日本Endurology/ESWL学会総会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 透析腎癌の臨床病理学的検討2009

    • Author(s)
      佐々直人、服部良平、吉野能、都築豊徳、後藤百万
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山市
    • Year and Date
      2009-04-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 透析腎癌の臨床病理学的検討2009

    • Author(s)
      佐々直人
    • Organizer
      第97回日本泌尿器科学会総会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] 名古屋大学におけるGemcitabine化学療法の検討2009

    • Author(s)
      佐々直人
    • Organizer
      第47回日本癌治療学会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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