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Research and regenerative therapy for microcirculation injury in the chemotherapy-affected kidney using biomarkers.

Research Project

Project/Area Number 21592072
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNagoya University

Principal Investigator

YOSHINO Yasushi  名古屋大学, 医学部附属病院, 講師 (70324415)

Co-Investigator(Kenkyū-buntansha) GOTOH Momokazu  名古屋大学, 大学院・医学系研究科, 教授 (10186900)
YAMAMOTO Tokunori  名古屋大学, 医学部附属病院, 講師 (20182636)
KATO Masashi  名古屋大学, 大学院・医学系研究科, 助教 (10362229)
小松 智徳  名古屋大学, 医学系研究科, 助教 (20378144)
舟橋 康人  名古屋大学, 医学部附属病院, 病院助教 (70534824)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords化学療法 / 腎機能 / バイオマーカー / 腎微小循環 / シスプラチン / 幹細胞 / 分子標的治療
Research Abstract

The time-intensity curve predicts the ischemic toxicity in the patients undergoing kidney transplantation. It prolonged in the kidney with malignant disease. The time-intensity curve is one of the biomarkers indicating that tumors have malignant components. It also predicts the ischemic toxicity and therapeutic effectiveness on kidneys undergoing target therapy or chemotherapy. Preoperative target therapy using Tyrosine-kinase inhibitor(TKI) was administered for patients with kidney cancer. Histopathological finding indicated TKI decreased the diameter of the small artery in the kidney. Microcirculation is associated with medical effects on tumor shrinkage. The biomarkers indicating microcirculation injury such as the time-intensity curve, liver type fatty-acid binding protein(L-FABP) and enhanced CT findings can be useful predictors of cancer therapy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Downsizing a Thrombus of Advanced Renal Cell Carcinoma in a Presurgical Setting with Sora fenib2011

    • Author(s)
      Takeda H, Nakano Y, Kashiwagi Y, Yoshino Y, Gotoh M
    • Journal Title

      Urol Int

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Downsizing a Thrombus of Advanced Renal Cell Carcinoma in a Presurgical Setting with Sorafenib2011

    • Author(s)
      武田宗万
    • Journal Title

      Urol Int.

      Volume: ePub

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contrast-enhanced ultrasound using a time-intensity curve for the diagnosis of renal cell carcinoma2010

    • Author(s)
      Aoki S, Hattori R, Yamamoto T, Funahashi Y, Matsukawa Y, Gotoh M, Yamada Y, Honda N
    • Journal Title

      BJU Int

      Volume: 108(3) Issue: 3 Pages: 349-354

    • DOI

      10.1111/j.1464-410x.2010.09799.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Contrast-enhanced ultrasound using a time-intensity curve for the diagnosis of renal cell carcinoma.2010

    • Author(s)
      青木重之
    • Journal Title

      BJU Int.(Epub)

      Volume: Nov2.doi(Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Usefulness of contrast-enhanced ultrasound using a time-intensity curve for the diagnosis of cystic renal cell carcinoma2011

    • Author(s)
      Aoki S, Nishikawa G, Yoshizawa T, Kato Y, Zennami K, Tobiume M, Nakamura K, Yamada Y, Honda N, Yamamoto T, Hattori R, Gotoh M
    • Organizer
      106^<th> Annual Meeting of American Urological Assosiation
    • Year and Date
      2011-05-18
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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