Research of prevention for urolithiasis considering gene and environmental factor, related metabolic syndrome.
| Project/Area Number |
21592076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
FUJITA Keiji 名古屋市立大学, 大学院・医学研究科, 研究員 (50264734)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Yasunori 名古屋市立大学, 大学院・医学研究科, 研究員 (70295608)
YASUI Takahiro 名古屋市立大学, 大学院・医学研究科, 講師 (40326153)
TOZAWA Keiichi 名古屋市立大学, 大学院・医学研究科, 准教授 (40264733)
KOHRI Kenjiro 名古屋市立大学, 大学院・医学研究科, 教授 (30122047)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 尿路結石症 / メタボリックシンドローム / アディポサイトカイン / ストレス感受性シグナル / オステオポンチン / 結石モデルマウス / OPNノックアウトマウス / OPNトランスジェニックマウス / 酸化ストレス |
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| Research Abstract |
Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] The role of long-term loading of cholesterol in renal crystal formation2011
Author(s)
Itoh Yasunori, Yoshimura Mugi, Niimi Kazuhiro, Usami Masayuki, Hamamoto Shuzo, Kobayashi Takahiro, Hirose Masahito, Okada Atsushi, Yasui Takahiro, Tozawa Keiichi, Kohri Kenjiro
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Journal Title
Archivio Italiano di Urologia e Andrologia
Volume: 83
Pages: 23-5
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Peer Reviewed
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[Journal Article]2009
Author(s)
伊藤恭典, 郡健二郎
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Journal Title
アンモニア代謝異常と尿路結石症(腎と透析)
Pages: 69-72
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[Presentation] Efficacy of a selective alpha 1A adrenoceptor antagonist as a medical exclusive therapy against ureteral stones2011
Author(s)
Itoh Yasunori, Okada Atsushi, Yasui Takahiro, Taguchi Kazumi, Niimi Kazuhiro, Fujii Yasuhiro, Hirose Yasuhiko, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Fujita Keiji, Tozawa Keiichi, Kohri Kenjiro
Organizer
1^<st> Meeting ofthe EAUSection of Urolithiasis(EULIS)
Place of Presentation
London(United Kingdom)
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[Presentation] Satisfaction with voiding, appearance, and sexual function in adolescents after hypospadias repair during childhood2009
Author(s)
Nakane Akihiro, Hayashi Yutaro, Kurokawa Satoshi, Kamisawa Hideyuki, Imura Makoto, Mizuno Kentaro, Kato Toshiki, Kojima Yoshiyuki, Maruyama Tetsuji, Kohri Kenjiro
Organizer
AUA 2009 Annual Meeting
Place of Presentation
Chicago(USA)
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[Presentation] Osteopontin has an important role in kidney stone formation and elimination via renal macrophage recruitment and activation2009
Author(s)
Okada Atsushi, Tozawa Keiichi, Niimi Kazuhiro, Hirose Yasuhiko, Kobayashi Takahiro, Usami Masayuki, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Yasui Takahiro, Hayashi Yutaro, Kohri Kenjiro
Organizer
AUA 2009 Annual Meeting
Place of Presentation
Chicago(USA)
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[Presentation] The role of NF-KB on renal stone formation2009
Author(s)
Tozawa Keiichi, Yasui Takahiro, Hirose Masahito, Usami Masayuki, Hamamoto Shuzo, Hirose Yasuhiko, Okada Atsushi, Itoh Yasunori, Hayashi Yutaro, Kohri Kenjiro
Organizer
AUA 2009 Annual Meeting
Place of Presentation
Chicago(USA)
Related Report
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