The study on the molecular mechanisms of development of endometriosis and estrogen-dependent gynecologic cancer
| Project/Area Number |
21592089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YANO Tetsu 東京大学, 医学部附属病院, 准教授 (90251264)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Shunsuke 東京大学, 医学部附属病院, 助教 (70270874)
HIRAIKE Osamu 東京大学, 医学部附属病院, 助教 (20529060)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エストロゲン / 受容体 / 卵巣癌 / 子宮内膜癌 / 乳癌 / マイクロアレイ / BRCA1 SIRT1 / 漿液性腺癌 / 明細胞腺癌 / 類内膜腺癌 / SNP / 染色体コピー数 / 癌遺伝子 / エストロゲン受容体 / ホルモン依存性腫瘍 / 癌抑制遺伝子 / BRCA1 / SIRT1 / TFII-I / エストロゲン受容体α / エストロゲン受容体β / DBC1 |
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| Research Abstract |
The expression of DBC1(deleted in breast cancer 1), a putative tumor-suppressor gene, negatively regulates the ligand-dependent transcriptional activation function of ERβwhich appears to protect against the mitogenic effect of estrogen in breast tissue. The expression of DBC1 also represses the transcriptional activation function of BRCT and inhibits the transactivation of SIRT1 promoter mediated by BRCA1. In contrast, the expression of TFII-I, a multifunctional transcriptional factor, stimulates the transcriptional activation function of BRCT and enhances the transactivation of SIRT1 promoter mediated by BRCA1. These results suggest that DBC1 may be tumorigenic and TFII-I may be antitumorigenic, and have important implications to understand the development of breast cancer. In epithelial ovarian cancer, SNP array and DNA microarray reveal that chromosomal instability and gene expression profiles depend on the histological type, which may serve as a reference to determine a treatment strategy.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Multifunctional transcription factor TFII-I is an activator of BRCA1 function2011
Author(s)
Tanikawa M, Wada-Hiraike O, Nakagawa S, Shirane A, Hiraike H, Koyama S, Miyamoto Y, Sone K, Tsuruga T, Nagasaka K, Matsumoto Y, Ikeda Y, Shoji K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Br J Cancer
Volume: 104
Pages: 1349-1355
Related Report
Peer Reviewed
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[Journal Article] The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction2010
Author(s)
Nagasaka K, Pim D, Massimi P, Thomas M, Tomai. V, Subbaiah VK, Kranjec C, Nakagawa S, Yano T, Taketani Y, Myers M, Banks L
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Journal Title
Oncogene
Volume: 29
Pages: 5311-5321
Related Report
Peer Reviewed
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[Journal Article] Identification of DBC1 as a transcriptional repressor for BRCA12010
Author(s)
Hiraike H, Wada-Hiraike O, Nakagawa S, Koyama S, Miyamoto Y, Sone K, Tanikawa M, Tsuruga T, Nagasaka K, Matsumoto Y, Oda K, Shoji K, Fukuhara H, Saji S, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Br J Cancer
Volume: 102
Pages: 1061-1067
Related Report
Peer Reviewed
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[Journal Article] Repression of estrogen receptor beta function by putative tumor suppressor DBC12010
Author(s)
Koyama S, Wada-Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, Sone K, Oda K, Fukuhara H, Nakagawa K, Kato S, Yano T, Taketani Y
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Journal Title
Biochem Biophys Res Commun
Volume: 392
Pages: 357-362
Related Report
Peer Reviewed
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[Journal Article] Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway2010
Author(s)
Murayama-Hosokawa S, Oda K, Nakagawa S, Ishikawa S, Yamamoto S, Shoji K, Ikeda Y, Uehara Y, Fukayama M, McCormick F, Yano T, Taketani Y, Aburatani H
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Journal Title
Oncogene
Volume: 29
Pages: 1897-1908
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Peer Reviewed
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[Journal Article] Somatic mutations are present in all members of the AKT family in endometrial carcinoma2009
Author(s)
Shoji K, Oda K, Nakagawa S, Hosokawa S, Nagae G, Uehara Y, Sone K, Miyamoto Y, Hiraike H, Hiraike-Wada O, Nei T, Kawana K, Kuramoto H, Aburatani H, Yano T, Taketani Y. Reply
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Journal Title
Br J Cancer
Volume: 101
Pages: 1220-1221
Related Report
Peer Reviewed
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[Journal Article] The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas2009
Author(s)
Shoji K, Oda K, Nakagawa S, Hosokawa S, Nagae G, Uehara Y, Sone K, Miyamoto Y, Hiraike H, Hiraike-Wada O, Nei T, Kawana K, Kuramoto H, Aburatani H, Yano T, Taketani Y
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Journal Title
Br J Cancer
Volume: 101
Pages: 145-148
Related Report
Peer Reviewed
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[Presentation] Microsatellite instability correlates with co-occurring mutations in the phosphatidyl inositol 3-kinase pathway in endometrial adenocarcinomas2009
Author(s)
Shoji K, Oda K, Hosokawa S, Nakagawa S, Uehara Y, Kawana K, Fujii T, Yano T, McCormick F, Aburatani H, Taketani Y
Organizer
100^<th> Annual Meeting of the American Association for Cancer Research
Place of Presentation
Denver, USA
Related Report
