| Project/Area Number |
21592090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIYASAKA Naoyuki 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員 (70313252)
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| Co-Investigator(Kenkyū-buntansha) |
TOBA Mikayo 東京医科歯科大学, 大学院・医歯学総合研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 妊娠高血圧症候群 / 子癇 / MRI / 脳浮腫 / 血液脳関門 |
|---|
| Research Abstract |
To clarify the pathophysiology of pregnancy related cerebrovascular disease, we conducted this preliminary in vivo study. There was no difference BBB permeability during acute hypertension compared with late pregnant rats and non-pregnant rats. The required dose of presser agents to elevate blood pressure that the brain autoregulation mechanism breakthrough probably occurred was significantly great late pregnant rats than non pregnant rats. The areas of brain edema formation in both groups were mainly occipital lobes, but more widely spread in non-pregnant rats. Those differences might be affected by pregnancy related automatic nerve function and vascular endothelial functions.
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