| Project/Area Number |
21592096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Kyoto University |
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Principal Investigator |
TATSUMI Keiji 京都大学, 医学研究科, 講師 (10324633)
|
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| Co-Investigator(Kenkyū-buntansha) |
KAKUI Kazuyo 京都大学, 医学研究科, 助教 (40531067)
KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 胎盤 / ニューロトロフィン / 子宮内胎児発育遅延 / 妊娠高血圧症候群 / 臍帯血 |
|---|
| Research Abstract |
Expression of TrkB, a neurotrophin receptor, was increased in placentas of intrauterine growth restriction(IUGR), pregnancy induced hypertension(PIH) or small twins. Brain-derived neurotrophic factor(BDNF), the ligand of TrkB, was higher in maternal plasma in PIH patients. BDNF/TrkB signaling had anti-apoptotic effects against oxidative stress in cultured villous tissue explants and a choriocarcinoma cell line, suggesting a protective role of BDNF/TrkB under unfavorable conditions in utero.
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