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Inhibition of cell proliferation of human endometriotic cells by parthenolide

Research Project

Project/Area Number 21592098
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTottori University

Principal Investigator

TANIGUCHI Fuminori  鳥取大学, 医学部附属病院, 講師 (40322218)

Co-Investigator(Kenkyū-buntansha) HARADA Tasuku  鳥取大学, 医学部, 教授 (40218649)
IWABE Tomio  鳥取大学, 医学部, 准教授 (10284001)
DEURA Imari  鳥取大学, 医学部附属病院, 助教 (50464293)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords薬用ハーブ / 子宮内膜症 / パルテノライド / エストロゲン
Research Abstract

The aim of this study was to investigate the usefulness of apigenin(flavonoid) and parthenolide(plant feverfew) as a possible therapeutic agent for endometriosis.(1) Apigenin suppressed mitogenic activity and PGE2 synthesis in endometriotic stromal cells(ESCs).(2) With parthenolide pretreatment, TNF.-induced IL-8 expression were repressed in ESCs. TNF.-induced COX-2 expression and PGE2 synthesis were also inhibited. Parthenolide suppressed ESCs proliferation by inhibition of NF. B pathway, Using the murine endometriosis model, administrating parthenolide significantly reduced the endometriotic lesions.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (39 results)

All 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (23 results)

  • [Journal Article] Apigenin inhibits tumor necrosis factor a-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFkB in endometriotic stromal cells2011

    • Author(s)
      Suou K, Taniguchi F, Harada T, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(4) Pages: 1518-1521

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frontier and Bioscience2011

    • Author(s)
      Taniguchi F, Iwabe T, Harada T, et al Apoptosis and endometriosis
    • Volume
      1(3)
    • Pages
      648-662
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant upregulation in endometriotic tissues2011

    • Author(s)
      Izawa M, Taniguchi F, Harada T, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95 Pages: 33-39

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells2011

    • Author(s)
      Suou K, Terakawa N, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(4) Issue: 4 Pages: 1518-1521

    • DOI

      10.1016/j.fertnstert.2010.09.046

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis and endometriosis2011

    • Author(s)
      Taniguchi F, Terakawa N, et al
    • Journal Title

      Frontier and Bioscience

      Volume: 1(3) Issue: 1 Pages: 648-662

    • DOI

      10.2741/277

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant upregulation in endometriotic tissues2011

    • Author(s)
      Izawa M, Terakawa N, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(1) Issue: 1 Pages: 33-39

    • DOI

      10.1016/j.fertnstert.2010.06.024

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apigenin inhibits tumor necrosis factor α-induced cell proliferation and prostaglandin E2 synthesis by inactivating NFκB in endometriotic stromal cells.2011

    • Author(s)
      Suou, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(4) Pages: 1518-1521

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Demethylation of a nonpromotor cytosine-phosphate-guanine island in the aromatase gene may cause the aberrant upregulation in endometriotic tissues.2011

    • Author(s)
      Izawa, et al
    • Journal Title

      Fertility and Sterility

      Volume: 95(1) Pages: 33-39

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide promoted proliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression2010

    • Author(s)
      Takenaka Y, Taniguchi F, Terakawa N, Harada T, et al
    • Volume
      93(1)
    • Pages
      325-327
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis2009

    • Author(s)
      Watanabe A, Taniguchi F, Terakawa N, Harada T, et al
    • Journal Title

      Hum Reprod

      Volume: 24(12) Pages: 3172-3179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TAK1 activation for cytokine synthesis and proliferation of endometriotic cells2009

    • Author(s)
      Taniguchi F, Harada T, Terakawa N, et al
    • Journal Title

      Mol Cell Endocrinol

      Volume: 307(1-2) Pages: 196-204

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNF alpha gene silencing reduced lipopolysaccharide-promoted proliferation of endometriotic stromal cells2009

    • Author(s)
      Miyamoto A, Taniguchi F, Harada T, et al
    • Journal Title

      Am J Reprod Immunol

      Volume: 61(4) Pages: 277-285

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-10 attenuates TNF-alpha-induced interleukin-6 production in endometriotic stromal cells2009

    • Author(s)
      Tagashira Y, Taniguchi F, Harada T, et al
    • Journal Title

      Fertil Steril

      Volume: 91 Pages: 2185-2192

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] TAK1 activation of cytokine synthesis and proliferation of endometriotic cells.2009

    • Author(s)
      Taniguchi F., et al.
    • Journal Title

      Molecular Cellular Endocrinology 13

      Pages: 196-204

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of survivin in the resistance of endometriotic stromal cells to drug-induced apoptosis.2009

    • Author(s)
      Watanabe A., et al.
    • Journal Title

      Human Reproduction 24(12)

      Pages: 3172-3179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TNF alpha gene silencing reduced lipopolysaccharide-promoted proliferation of endometrintic stromal cells.2009

    • Author(s)
      Miyamoto A., et al.
    • Journal Title

      American Journal Reproductive Immunology 61(4)

      Pages: 277-285

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 薬用ハーブによる子宮内膜症間質細胞の増殖およびPGE2産生抑制2012

    • Author(s)
      高井絵理・谷口文紀, 他
    • Organizer
      第33回日本エンドメトリオーシス学会
    • Place of Presentation
      ホテルニュー長崎(長崎市)
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 薬用ハーブによる子宮内膜症間質細胞の増殖およびPGE2産生抑制2011

    • Author(s)
      高井絵理、谷口文紀、原田省, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 薬用ハーゾによる子宮内膜症間質細胞の増殖およびPGE2産生抑制2011

    • Author(s)
      高井絵理・谷口文紀, 他
    • Organizer
      第56回日本生殖医学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-12-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] ジェノゲストによる子宮内膜症間質細胞の増殖抑制作用とその機序2011

    • Author(s)
      谷口文紀、出浦伊万里、岩部富夫、原田省, 他
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島市
    • Year and Date
      2011-11-11
    • Related Report
      2011 Final Research Report
  • [Presentation] TNFαis a potent mediator of regulating IAP expression in endometriotic cells2011

    • Author(s)
      Taniguchi F, Terakawa N, Harada T, et al.
    • Organizer
      67th Annual Meeting of American Society for Reproductive Medicine
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2011-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] TNFα is a potent mediator of regulating IAPs expression in endometriotic cells2011

    • Author(s)
      谷口文紀, 他
    • Organizer
      第67回米国生殖医学会
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮内膜症細胞におけるエストロゲン受容体αの発現解析2011

    • Author(s)
      東幸弘、谷口文紀、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術
    • Place of Presentation
      大阪市
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 正所性子宮内膜および子宮内膜症組織におけるIAPファミリー発現の差異2011

    • Author(s)
      上垣崇、谷口文紀、岩部富夫、原田省, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Aberrant expression of IAP family in endometriotic cells may cause resistance to apoptosis2011

    • Author(s)
      Taniguchi F, Harada T, et al
    • Organizer
      93th Annual Meeting of Endocrine Society
    • Place of Presentation
      Boston, USA
    • Year and Date
      2011-07-07
    • Related Report
      2011 Final Research Report
  • [Presentation] Aberrant expression of IAP family in endometriotic cells may causere sistance to apoptosis2011

    • Author(s)
      谷口文紀, 他
    • Organizer
      第93回米国内分泌学会
    • Place of Presentation
      ボストン(米国)
    • Year and Date
      2011-06-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 正所性子宮内膜および子宮内膜症組織におけるIAP family発現の差異2010

    • Author(s)
      上垣崇・谷口文紀, 他
    • Organizer
      第55回 日本生殖医学会
    • Place of Presentation
      あねぎんホール(徳島市)
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] The mechanism of resistance to apoptosis in endometriosis2010

    • Author(s)
      Taniguchi F, Harada T, et al
    • Organizer
      The First Asian Conference on Endometriosis
    • Place of Presentation
      Shanghai, China
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] アピゲニンによる子宮内膜症間質細胞の増殖およびPGE2産生の抑制2010

    • Author(s)
      周防加奈・谷口文紀, 他
    • Organizer
      第62回 日本産科婦人科学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮内膜症細胞のアポトーシス抵抗性におけるSurvivinの関与2010

    • Author(s)
      谷口文紀、出浦伊万里、岩部富夫、原田省, 他
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Apigeninによる子宮内膜症間質細胞の増殖およびPGE2産生の抑制2010

    • Author(s)
      周防加奈、谷口文紀、出浦伊万里、岩部富夫、原田省, 他
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] アピゲニンによる子宮内膜症間質細胞の増殖抑制2009

    • Author(s)
      周防加奈・谷口文紀
    • Organizer
      第54回 日本生殖医学会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-11-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] Apigenin inhibits TNFα-induced cell proliferation in endometriotic stromal cells2009

    • Author(s)
      Taniguchi F, Iwabe T, Harada T, et al
    • Organizer
      65^<th> Annual Meeting of American Societh for Reproductive Medicine
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Possible involvement of survivin in resistance to drug-induced apoptosis of endometriotic stromal cells2009

    • Author(s)
      Watanabe A, Taniguchi F, Harada T, et al
    • Organizer
      65^<th> Annual Meeting of American Societh for Reproductive Medicine
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2009-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞のアロマターゼ発現にはDNAのメチル化が関与する2009

    • Author(s)
      原田省、谷口文紀、岩部富夫, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] パスウェイ特異的アレイを用いた子宮内膜症細胞のアポトーシス抵抗性の解明2009

    • Author(s)
      渡邉彩子、谷口文紀、岩部富夫、原田省, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] LPSによる子宮内膜症細胞のPGE2産生誘導と細胞増殖および浸潤作用2009

    • Author(s)
      竹中泰子、谷口文紀、原田省, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞の増殖におけるシグナル分子TAK1の役割2009

    • Author(s)
      谷口文紀、岩部富夫、原田省, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 子宮内膜症細胞の増殖におけるシグナル分子TAK1の役割2009

    • Author(s)
      谷口文紀
    • Organizer
      第61回 日本産科婦人科学会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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