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regulation of gonadotropin secretion by novel brain peptides and stresses

Research Project

Project/Area Number 21592100
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokushima

Principal Investigator

MATSUZAKI Toshiya  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70294692)

Co-Investigator(Kenkyū-buntansha) IRAHARA Minoru  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (20160070)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords生殖医学 / ゴナドトロピン分泌 / 視床下部 / 神経ペプチド / プログラミング / ストレス / キスペプチン / RFRP / GnIH / 絶食 / kisspeptin / 絶食ストレス / 性機能 / レプチン / ゴナドトロピン / 感染ストレス / 摂食
Research Abstract

Expression of novel hypothalamic peptide RFRP increases during development. Suppression of kisspeptin expression by starvation was acquired in neonatal period, and plays an important role for suppression of gonadal function. Stresses during perinatal and neonatal period result in long-lasting influences on sexual function, therefore, it should be better to avoid stresses in tese peropds.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (116 results)

All 2012 2011 2010 2009

All Journal Article (39 results) (of which Peer Reviewed: 36 results) Presentation (73 results) Book (4 results)

  • [Journal Article] Effects of lipopolysaccharide exposure at different postnatal time points on the response of LH to homotypic stress in adulthood.2012

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Nakazawa H, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      J Reprod Immunol

      Volume: 94(2) Issue: 2 Pages: 155-160

    • DOI

      10.1016/j.jri.2012.02.003

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in insulin sensitivity during GnRH agonist treatment in premenopausal women with leiomyoma2012

    • Author(s)
      Matsui S, Yasui T, Tani A, Kunimi K, Uemura H, Yamamoto S, Kuwahara A, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M.
    • Journal Title

      Clin Chim Acta

      Volume: 413(11-12) Issue: 11-12 Pages: 960-965

    • DOI

      10.1016/j.cca.2012.01.040

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Okadaic acid-sensitive phosphatase is related to MII/ G1 transition in mouse oocytes2012

    • Author(s)
      Moride N, Kuwahara A, Sutoh A, Tanaka Y, Mukai Y, Yamashita M, Matsuzaki T, Yasui T, Irahara M.
    • Journal Title

      Zygote

      Volume: 20(2) Issue: 2 Pages: 193-198

    • DOI

      10.1017/s0967199411000013

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental changes in the mammalian gonadotropin-inhibitory hormone(GnIH) ortholog RFamide-related peptide(RFRP) and its cognate receptor GPR147 in the rat hypothalamus.2011

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Osugi T, Gereltsetseg G, Yoshida S, Irahara M, Tsutsui K.
    • Journal Title

      Int J Dev Neurosci

      Volume: 30(1) Issue: 1 Pages: 31-37

    • DOI

      10.1016/j.ijdevneu.2011.10.003

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fasting reduces the kiss1 mRNA levels in the caudal hypothalamus of gonadally intact adult female rats2011

    • Author(s)
      Matsuzaki T, Iwasa T, Kinouchi R, Yoshida S, Murakami M, Gereltsetseg G, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      Endocrine Journal

      Volume: 58 Issue: 11 Pages: 1003-1012

    • DOI

      10.1507/endocrj.K11E-131

    • NAID

      10030392301

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of immune stress on body weight regulation is altered by ovariectomy in female rats2011

    • Author(s)
      Iwasa T, Matsuzaki T, Kinouchi R, Gereltsetseg G, Murakami M, Nakazawa H, Fujisawa S, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      J Reprod Immunol

      Volume: 91(1-2 Issue: 1-2 Pages: 41-47

    • DOI

      10.1016/j.jri.2011.05.010

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The possibility of vertical transmission of human papillomavirus through maternal milk2011

    • Author(s)
      Yoshida K, Furumoto H, Abe A, Kato T, Nishimura M, Kuwahara A, Maeda K, Matsuzaki T, Irahara M.
    • Journal Title

      J Obstet Gynaecol

      Volume: 31(6) Issue: 6 Pages: 503-506

    • DOI

      10.3109/01443615.2011.570814

    • NAID

      120006718353

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in responsiveness of appetite, leptin and hypothalamic IL-1βand TNF-αto lipopolysaccharide in developing rats2011

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Nakazawa H, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      J Neuroimmunol

      Volume: 236(1-2) Issue: 1-2 Pages: 10-16

    • DOI

      10.1016/j.jneuroim.2011.04.004

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the responsiveness of serum leptin and hypothalamic neuropeptide Y mRNA levels to food deprivation in developing rats2011

    • Author(s)
      Iwasa T, Matsuzaki T, Kinouchi R, Gereltsetseg G, Murakami M, Nakazawa H, Yasui T, Irahara M.
    • Journal Title

      rats. Int J Dev Neurosci

      Volume: 29(4) Issue: 4 Pages: 377-380

    • DOI

      10.1016/j.ijdevneu.2011.03.006

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed puberty in prenatally glucocorticoid administered female rats occurs independently of the hypothalamic Kiss1-Kiss1r-GnRH system2011

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Yamamoto S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      Int J Dev Neurosci

      Volume: 29(2) Issue: 2 Pages: 183-188

    • DOI

      10.1016/j.ijdevneu.2010.11.001

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of semen characteristics on pregnancy rate following intrauterine insemination2011

    • Author(s)
      Dorjpurev U, Kuwahara A, Yano Y, Taniguchi T, Yamamoto Y, Suto A, Tanaka Y, Matsuzaki T, Yasui T, Irahara M.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 58 Issue: 1,2 Pages: 127-133

    • DOI

      10.2152/jmi.58.127

    • NAID

      130004465234

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of raloxifene on the production of cytokines in stimulated whole blood in ex vivo and in vitro studies2011

    • Author(s)
      Kasai Y, Maegawa M, Yamamoto S, Kamada M, Yasui T, Uemura H, Kobayashi A, Kaneyama M, Tani A, Matsui S, Kuwahara A, Matsuzaki T, Furumoto H, Irahara M.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 58 Issue: 1,2 Pages: 110-117

    • DOI

      10.2152/jmi.58.110

    • NAID

      130004465232

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Does the bromocriptine-rebound method improve embryo quality?2011

    • Author(s)
      Moride N, Kuwahara A, Yamashita M, Tanaka Y, Matsuzaki T, Yasui T, Irahara M.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 58 Issue: 1,2 Pages: 63-66

    • DOI

      10.2152/jmi.58.63

    • NAID

      130004465246

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropeptide Y mediates orexin A-mediated suppression of pulsatile gonadotropin-releasing hormone secretion in ovariectomized rats2011

    • Author(s)
      Kiyokawa M, Matsuzaki T, Iwasa T, Ogata R, Murakami M, Kinouchi R, Yoshida S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      The Journal of Medical Investigation

      Volume: 58 Issue: 1,2 Pages: 11-18

    • DOI

      10.2152/jmi.58.11

    • NAID

      130004465231

    • ISSN
      1343-1420, 1349-6867
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropeptide Y mediates orexin A-mediated suppression of pulsatile gonadotropin-releasing hormone secretion in ovariectomized rats.2011

    • Author(s)
      Kiyokawa M, nine others.
    • Journal Title

      J Med Invest.

      Volume: 58 Pages: 11-18

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Does the bromocriptine-rebound method improve embryo quality?2011

    • Author(s)
      Moride N, six others.
    • Journal Title

      J Med Invest.

      Volume: 58 Pages: 63-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of raloxifene on the production of cytokines in stimulated whole blood in ex vivo and in vitro studies.2011

    • Author(s)
      Kasai Y, thirteen others.
    • Journal Title

      J Med Invest.

      Volume: 58 Pages: 110-117

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of semen characteristics on pregnancy rate following intrauterine insemination.2011

    • Author(s)
      Dorjpurev U, nine others.
    • Journal Title

      J Med Invest.

      Volume: 58 Pages: 127-133

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats2010

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Gereltsetseg G, Fujisawa S, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      J Endocrinol

      Volume: 207(2) Issue: 2 Pages: 195-202

    • DOI

      10.1677/joe-10-0129

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats2010

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Fujisawa S, Kinouchi R, Gereltsetseg G, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      J Physiol

      Volume: 588(Pt 5) Issue: 5 Pages: 821-829

    • DOI

      10.1113/jphysiol.2009.183558

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of N-terminal pro B-type natriuretic peptide and sex hormone-binding globulin in non-obese peri-and postmenopausal women2010

    • Author(s)
      Yasui T, Matsui S, Saijo A, Kaji T, Yamamoto S, Uemura H, Matsuzaki T, Irahara M.
    • Journal Title

      Clin Chim Acta

      Volume: 411(3-4) Issue: 3-4 Pages: 280-284

    • DOI

      10.1016/j.cca.2009.11.025

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal LPS injection alters the body weight regulation systems of rats under non-stress and immune stress conditions2010

    • Author(s)
      Iwasa T, Matsuzaki T, Kinouchi R, Fujisawa S, Murakami M, Kiyokawa M, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      Int J Dev Neurosci

      Volume: 28(1) Issue: 1 Pages: 119-124

    • DOI

      10.1016/j.ijdevneu.2009.08.015

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitivities of mRNA expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats.2010

    • Author(s)
      Iwasa T, eight others.
    • Journal Title

      J Endocrinol.

      Volume: 207 Pages: 195-202

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多嚢胞性卵巣症候群2010

    • Author(s)
      松崎利也, 他3名
    • Journal Title

      産科と婦人科

      Volume: 77(11) Pages: 1325-1333

    • Related Report
      2010 Annual Research Report
  • [Journal Article] エクルーシス試薬テストステロンII,LH,FSHの基準値の検討2010

    • Author(s)
      木内理世, 他4名
    • Journal Title

      医学と薬学

      Volume: 64巻1号 Pages: 87-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal LPS injection alters the body weight regulation systems of rats under non-stress and immune stress conditions.2010

    • Author(s)
      Iwasa T, et. al.
    • Journal Title

      Int J Dev Neurosci. 28

      Pages: 119-124

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of intrauterine undernutrition on hypothalamic Kiss1 expression and the timing of puberty in female rats.2010

    • Author(s)
      Iwasa T, et. al.
    • Journal Title

      J Physiol. 588

      Pages: 821-829

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic Ghrelin suppresses pulsatile secretion of luteinizing hormone via beta-endorphin in ovariectomized rats2009

    • Author(s)
      Ogata R, Matsuzaki T, Iwasa T, Kiyokawa M, Tanaka N, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      Neuroendocrinology

      Volume: 90(4) Issue: 4 Pages: 364-370

    • DOI

      10.1159/000257421

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of oral and transdermal estrogen therapies on circulating cytokines and chemokines in postmenopausal women with hysterectomy2009

    • Author(s)
      Yasui T, Saijo A, Uemura H, Matsuzaki T, Tsuchiya N, Yuzurihara M, Kase Y, Irahara M.
    • Journal Title

      Eur J Endocrinol

      Volume: 161(2) Issue: 2 Pages: 267-273

    • DOI

      10.1530/eje-09-0063

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome2009

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Shimizu F, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 35(3) Issue: 3 Pages: 514-519

    • DOI

      10.1111/j.1447-0756.2008.00998.x

    • NAID

      10025340283

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced suppression of LH secretion in adulthood in male rat2009

    • Author(s)
      Iwasa T, Matsuzaki T, Murakami M, Kinouchi R, Ogata R, Kuwahara A, Yasui T, Irahara M.
    • Journal Title

      Int J Dev Neurosci

      Volume: 27(4) Issue: 4 Pages: 345-349

    • DOI

      10.1016/j.ijdevneu.2009.03.004

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal immune challenge affects the regulation of estrus cyclicity and feeding behavior in female rats.2009

    • Author(s)
      Iwasa T, et. al.
    • Journal Title

      Int. J.Dev Neurosci. 7

      Pages: 111-114

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal lipopolysaccharide exposure attenuates the homotypic stress-induced spporession of LH secretion in adulthood in male rat.2009

    • Author(s)
      Iwasa T, et. al.
    • Journal Title

      Int. J.Dev Neurosci. 27

      Pages: 345-349

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic Ghrelin suppresses pulsatile secretion of luteinizing hormone via beta-endorphin in ovariectomized rats.2009

    • Author(s)
      Ogata R, et. al.
    • Journal Title

      Neuroendocrinology 90

      Pages: 364-370

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reproducibility of luteinizing hormone hypersecretion in different phases of the menstrual cycle in polycystic ovary syndrome.2009

    • Author(s)
      Iwasa T, et. al.
    • Journal Title

      J Obstet Gynaecol Res 35

      Pages: 514-519

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 続発性無月経と高プロラクチン血症を呈したマクロプロラクチン血症の1例2009

    • Author(s)
      清川麻知子, 他
    • Journal Title

      現代産婦人科 58

      Pages: 171-175

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胚盤胞を用いた単一胚移植で発生した一絨毛膜性二羊膜性双胎の検討2009

    • Author(s)
      清川麻知子, 他
    • Journal Title

      現代産婦人科 58

      Pages: 255-259

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FSH低用量漸増療法による多胎妊娠の防止2009

    • Author(s)
      松崎利也, 他
    • Journal Title

      産婦人科治療 98

      Pages: 648-657

    • NAID

      10018308933

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 新しい排卵誘発法2009

    • Author(s)
      松崎利也
    • Journal Title

      日本産科婦人科学会雑誌 61

      Pages: 325-329

    • Related Report
      2009 Annual Research Report
  • [Presentation] 第50回徳島不妊・内分泌研究会2012

    • Author(s)
      木内理世, 他
    • Organizer
      第50回徳島不妊・内分泌研究会
    • Place of Presentation
      ホテルグランドパレス徳島(徳島県徳島市)
    • Year and Date
      2012-02-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多嚢胞性卵巣症候群患者におけるメトホルミンの有用性の検討2011

    • Author(s)
      松崎利也, 他
    • Organizer
      第17回徳島内分泌研究会
    • Place of Presentation
      徳島グランヴィリオホテル(徳島市)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎生期にグルココルチコイドに暴露された雌ラットの思春期発来の遅延はkiss1-kiss1r-GnRH機構とは独立した機序でおこる2011

    • Author(s)
      木内理世, 他
    • Organizer
      第16回日本生殖内分泌学会学術集会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発達期のラット視床下部におけるRFRP発現の変動と性ステロイド作用に関する検討2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第16回日本生殖内分泌学会学術集会
    • Place of Presentation
      シェーンバッハ・サボー(東京都千代田区)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖領域におけるホルモン療法最前線-PCOSにおけるホルモン療法-2011

    • Author(s)
      松崎利也
    • Organizer
      第121回関東連合産科婦人科学会
    • Place of Presentation
      都市センターホテル(東京都千代田区)(シンポジウム)(招待講演)
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 排卵障害の診断と治療2011

    • Author(s)
      松崎利也
    • Organizer
      下関産婦人科医会学術集会
    • Place of Presentation
      東京第一ホテル下関(山口県下関市)(特別講演)(招待講演)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発達期ラット視床下部におけるRFRPの発現の検討2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第75回徳島産科婦人科合同学術集会
    • Place of Presentation
      偕楽園(徳島市)
    • Year and Date
      2011-01-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] テストステロンに対する特異性を改善した新測定系によるPCOSにおける高テストステロン血症検出率の向上2011

    • Author(s)
      松崎利也、木内理世、岩佐武、苛原稔
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Sensitivities of messenger ribonucleic acid expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed during the developmental period in female rats2011

    • Author(s)
      Matsuzaki T, Iwasa T, Kinouchi R, Gereltsetseg G, Irahara M.
    • Organizer
      The Endocrine Society' s 93rd Annual Meeting
    • Place of Presentation
      Boston Convention & Exhibition Center
    • Related Report
      2011 Final Research Report
  • [Presentation] 出生前後の栄養状態およびストレスが成長後の性機能に及ぼす影響シンポジウム「生殖機能の中枢性調節:最近の知見」2011

    • Author(s)
      松崎利也、岩佐武、苛原稔
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] 生殖機能の中枢性調節:最近の知見-出生前後の栄養状態およびストレスが成長後の性機能に及ぼす影響-2011

    • Author(s)
      松崎利也, 他
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(兵庫県神戸市)(シンポジウム)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多嚢胞性卵巣症侯群患者の排卵誘発におけるメトホルミンの有用性に関する検討2011

    • Author(s)
      松崎利也
    • Organizer
      第64回中国四国産科婦人科学会学術講演会
    • Place of Presentation
      ホテルクレメント徳島(徳島県徳島市)(特別講演)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 安全性と至便性を兼ね備えた排卵誘発法2011

    • Author(s)
      松崎利也
    • Organizer
      第59回北日本産科婦人科学会学術講演会
    • Place of Presentation
      秋田キャッスルホテル(秋田県秋田市)(ランチョンセミナー)(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Sensitivities of messenger ribonucleic acid expression levels of Kiss1 and its receptor, Kiss1r, to nutritional status are changed, during the developmental period in female rats2011

    • Author(s)
      Toshiya Matsuzaki, et.al.
    • Organizer
      The Endocrine Society's 93rd Annual Meeting
    • Place of Presentation
      Boston Convention & Exhibition Center (Boston, USA)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特異性を改善したテストステロン測定系による多嚢胞性卵巣症候群の内分泌的検討2011

    • Author(s)
      木内理世, 他
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(兵庫県神戸市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] kisspeptin関連遺伝子の栄養状態に対する感受性は出生後早期の発達過程において変化する2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場、神戸国際展示場(兵庫県神戸市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] テストステロンに対する特異性を改善した新測定系によるPCOSにおける高テストステロン血症検出率の向上2011

    • Author(s)
      松崎利也, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      リーガロイヤルホテル大阪、大阪国際会議場(大阪府大阪市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] テストステロンに対する特異度が高いエクルーシス試薬テストステロンIIの基準値の臨床的検討2011

    • Author(s)
      木内理世, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      リーガロイヤルホテル大阪、大阪国際会議場(大阪府大阪市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高プロラクチン血症として管理されていたマクロプロラクチン血症の2症例2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第64回中国四国日本産科婦人科学会学術講演会
    • Place of Presentation
      ホテルクレメント徳島(徳島県徳島市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 出生後早期の雌ラットにおけるkisspeptin関連遺伝子の栄養状態に対する感受性について2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発達期のラット視床下部におけるRFRPの発現に関する検討2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高プロラクチン血症として管理されていたマクロプロラクチン血症の2症例の検討2011

    • Author(s)
      中澤浩志, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多嚢胞性卵巣症候群患者におけるメトホルミンを用いた排卵誘発の有用性の検討2011

    • Author(s)
      松崎利也, 他
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Effect of Neonatal Nutritional Condition on the Timing of Puberty in Normal and IUGR Female Rats2011

    • Author(s)
      Gereltsetseg Ganbat, et.al.
    • Organizer
      第56回日本生殖医学会学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肥満を伴う月経異常患者に対する機能性食品を用いた減量療法の臨床的検討2010

    • Author(s)
      松崎利也, 他3名
    • Organizer
      第16回徳島内分泌研究会
    • Place of Presentation
      徳島市
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] アーキテクトを用いた多嚢胞性卵巣症候群における高LHの判定基準の設定2010

    • Author(s)
      松崎利也, 他3名
    • Organizer
      第43回日本産科婦人科学会四国連合地方部会学術講演会
    • Place of Presentation
      愛媛県松山市、松山市男女共同参画推進センター
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of stress and undernutrition on kisspeptin ssystem.2010

    • Author(s)
      Iwasa T, et. al.
    • Organizer
      The 14^<th> International Congress of Endocrineology Official Satellite Symposium "Comparative Endocrinoligy of Kisspeptin"
    • Place of Presentation
      Kyoto, Sakyo-ku, Japan
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生殖内分泌領域の最近の動向-日本産科婦人科学会のガイドライン等について-2010

    • Author(s)
      松崎利也
    • Organizer
      第47回徳島不妊・内分泌学会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      2010-02-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 母胎内の低栄養環境は出生後のkisspeptinの作用を低下させ思春期の発来を遅延させる2010

    • Author(s)
      岩佐武、松崎利也、木内理世、苛原稔
    • Organizer
      第15回日本生殖内分泌学会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2011 Final Research Report
  • [Presentation] シンポジウム「見過ごしてならない肥満合併症(婦人科、整形外科、呼吸器科、循環器科)」女性の肥満と月経異常2010

    • Author(s)
      松崎利也
    • Organizer
      第3回日本肥満症治療学会学術集会
    • Place of Presentation
      学術総合センター
    • Related Report
      2011 Final Research Report
  • [Presentation] Fujisawa S, Kinouchi R, Irahara M. Neonatal LPS Injection Alters the Body Weight Regulation Systems of Rats under Non-Stress and Immune Stress Conditions2010

    • Author(s)
      Matsuzaki T, Iwasa T, Fujisawa S, Kinouchi R, Irahara M.
    • Organizer
      The Endocrine Society' s 92nd Annual Meeting
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2011 Final Research Report
  • [Presentation] Neonatal lipopolysaccharide exposure attenuates the suppressive responses of LH secretion to homotypic immune challenge in adulthood in male rat. Poster Pressentations ; Reproduction and development 052010

    • Author(s)
      Matsuzaki T, Iwasa T, Kinouchi R, Gereltsetseg G, Irahara M.
    • Organizer
      The 14th international Congress of Endorinology
    • Place of Presentation
      京都国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] Neonatal LPS Injection Alters the Body Weight Regulation Systems of Rats under Non-Stress and Immune Stress Conditions.2010

    • Author(s)
      Matsuzaki T, four others.
    • Organizer
      The Endocrine Society's 92^<nd> Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of Intra-Uterine Undernutrition on Hypothalamic Kiss 1 Expression and the Timing of Puberty in Female Rats.2010

    • Author(s)
      Iwasa T, five others.
    • Organizer
      The Endocrine Society's 92^<nd> Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discovery of GnIH : first in birds and then in mammals Symposium : Gonadotropin inhibitory hormone (GnIH) functions in mammals.2010

    • Author(s)
      Tsutsui K, ten others.
    • Organizer
      The Endocrine Society's 92^<nd> Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロラクチンの再考 生涯研修プログラム「生殖医療のup-to-date」2010

    • Author(s)
      松崎利也
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都千代田区、東京国際フォーラム
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「見過ごしてならない肥満合併症(婦人科、整形外科、呼吸器科、循環器科)」女性の肥満と月経異常2010

    • Author(s)
      松崎利也
    • Organizer
      第3回日本肥満症治療学会学術集会
    • Place of Presentation
      東京都千代田区、学術総合センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 多嚢胞性卵巣症候群の診断と治療2010

    • Author(s)
      松崎利也
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島市、あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 雌ラット視床下部における絶食時のKiss-1mRNAの発現に関する検討2010

    • Author(s)
      松崎利也, 他4名
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都千代田区、東京国際フォーラム
    • Related Report
      2010 Annual Research Report
  • [Presentation] 全自動電気化学発光免疫測定法を用いた多嚢胞性卵巣症候群の診断における血中LH値、LH/FSH比の検討2010

    • Author(s)
      木内理世, 他4名
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都千代田区、東京国際フォーラム
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎生期の低栄養環境は出生後のkisspeptinの発現を低下させ性成熟と思春期初来を遅延させる2010

    • Author(s)
      岩佐武, 他4名
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都千代田区、東京国際フォーラム
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎生期の低栄養環境は出生後のkisspeptinの発現を低下させ思春期の発来を遅延させる2010

    • Author(s)
      岩佐武, 他4名
    • Organizer
      第63回中国四国産科婦人科学会学術講演会
    • Place of Presentation
      岡山県岡山市、岡山コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体重の増減が卵巣機能に影響を及ぼしたと思われる肥満排卵障害患者の2例2010

    • Author(s)
      松崎利也, 他4名
    • Organizer
      第63回中国四国産科婦人科学会学術講演会
    • Place of Presentation
      岡山県岡山市、岡山コンベンションセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胎生期の低栄養環境は出生後のkisspeptinの発現を低下させ思春期発来を遅延させる2010

    • Author(s)
      岩佐武, 他4名
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島市、あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体重の増減が排卵機能に影響を及ぼしたと思われる肥満を伴う不妊排卵障害患者の2例2010

    • Author(s)
      吉田しのぶ, 他4名
    • Organizer
      第55回日本生殖医学会学術講演会
    • Place of Presentation
      徳島県徳島市、あわぎんホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 母胎内の低栄養環境は出生後のkisspeptinの作用を低下させ思春期の発来を遅延させる2010

    • Author(s)
      岩佐武, 他3名
    • Organizer
      第15回日本生殖内分泌学会
    • Place of Presentation
      大阪府豊中市、千里ライフサイエンスセンター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discovery and functional sifnificance of gonadotropin-inhibitory horom one(GnlH) in vertebrates : From comparactive to general.2010

    • Author(s)
      Tsutsui K, et. al.
    • Organizer
      The 14^<th> International Congress of Endocrineology
    • Place of Presentation
      Kyoto, Sakyo-ku, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neonatal lipopolysaccharide exposure attenuates the suppressive responses of LH secretion to homotypic immune challenge in adulthood in male rat.2010

    • Author(s)
      Matsuzaki T, et al.
    • Organizer
      The 14^<th> International Congress of Endocrineology
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neonatal immune challenge affects the regulation of estrus cycle and feeding behavior in female rats.2010

    • Author(s)
      Iwasa T, et al.
    • Organizer
      The 14^<th> International Congress of Endocrineology
    • Place of Presentation
      Kyotot, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Assessment of serum LH level and LH/ FSH ratio using electrochemistry luminescence immunoassay method for the diagnosis of porycystic ovarysyndrome2009

    • Author(s)
      Matsuzaki T, Kinouchi R, Gereltsetseg G, Fujisawa S, Iwasa T, Irahara M.
    • Organizer
      The International Ovarian Conference
    • Place of Presentation
      大手町サンケイプラザ
    • Year and Date
      2009-12-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 雄ラットにおいて新生仔期の感染ストレスは成熟後の感染ストレスに対する性機能の反応を減弱させる2009

    • Author(s)
      岩佐武、松崎利也、藤澤しのぶ、木内理世、苛原稔
    • Organizer
      第14回日本生殖内分泌学会
    • Place of Presentation
      シェーンバッハ・サボー
    • Year and Date
      2009-11-28
    • Related Report
      2011 Final Research Report
  • [Presentation] 雄ラットにおいて新生仔期の感染ストレスは成熟後の感染ストレスに対する性機能の反応を視床下部で減弱させる2009

    • Author(s)
      岩佐武, 他
    • Organizer
      第14回日本生殖内分泌学会
    • Place of Presentation
      東京都千代田区
    • Year and Date
      2009-11-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体重の増減が卵巣機能に影響を及ぼしたと思われる肥満を伴う不妊排卵障害患者の2例2009

    • Author(s)
      藤澤しのぶ, 他
    • Organizer
      第15回徳島内分泌研究会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      2009-11-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Assessment of serum LH level and LH/FSH ratio using electrochemistry luminescence immunoassay method for the diagnosis of polycystic ovary syndrome.2009

    • Author(s)
      Matsuzaki T, et al.
    • Organizer
      The International Ovarian Conference 2009
    • Place of Presentation
      Otemachi Sankei Plaza, Chiyoda-ku, Tokyo
    • Year and Date
      2009-10-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 雌ラットにおける絶食時のKiSS-1mRNAの発現変化に関する研究2009

    • Author(s)
      岩佐武, 他
    • Organizer
      第17回中四国GnRH研究会
    • Place of Presentation
      岡山県岡山市
    • Year and Date
      2009-08-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体重増加によりインスリン抵抗性改善薬の排卵誘発効果が失われたと思われるPCOSの一例2009

    • Author(s)
      藤澤しのぶ, 他
    • Organizer
      第42回日本産科婦人科学会四国運合地方部会学術集会
    • Place of Presentation
      徳島県徳島市
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多嚢胞性卵巣症候群の診断とホルモン測定上の注意点2009

    • Author(s)
      松崎利也
    • Organizer
      第54回日本生殖医学会・学術講演会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢
    • Related Report
      2011 Final Research Report
  • [Presentation] Early life lipopolysaccharide expose attenuates the suppressive responses of LH serection to homotypic immune challenge in adulthood in male rat2009

    • Author(s)
      Matsuzaki T, Iwasa T, Kinouchi R, Irahara M.
    • Organizer
      The Endocrine Society' s 91st Annual Meeting
    • Place of Presentation
      Convention Center
    • Related Report
      2011 Final Research Report
  • [Presentation] 新生期のストレスが成熟後のストレスに対する性機能および摂食調節機構の反応に及ぼす影響2009

    • Author(s)
      岩佐武、松崎利也、木内理世、村上雅博、苛原稔
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県民会館、前橋商工会議所
    • Related Report
      2011 Final Research Report
  • [Presentation] 新しい排卵誘発治療2009

    • Author(s)
      松崎利也
    • Organizer
      第61回日本産婦人科学会学術講演会
    • Place of Presentation
      京都府京都市
    • Related Report
      2009 Annual Research Report
  • [Presentation] リコセビナントFSH製剤を用いた在宅注射による排卵誘発の実際2009

    • Author(s)
      松崎利也
    • Organizer
      第61回日本産婦人科学会学術講演会
    • Place of Presentation
      京都府京都市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多嚢胞性卵巣症候群の診断とホルモン測定上の注意点2009

    • Author(s)
      松崎利也
    • Organizer
      第54回日本生殖医学会・学術講演会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子組み換え卵胞刺激ホルモンと尿由来卵胞刺激ホルモンの第I度無月経、無排卵周期症患者を対象とした第III相多施設共同単盲検並行群間比較試験2009

    • Author(s)
      松崎利也, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都府京都市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生期が成熟後のストレスに対する性機能および摂食調節機構の反応に与える影響2009

    • Author(s)
      岩佐武, 他
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都府京都市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新生期のストレスが成熟後のストレスに対する性機能および摂食調節機構の反応に及ぼす影響2009

    • Author(s)
      岩佐武, 他
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県前橋市
    • Related Report
      2009 Annual Research Report
  • [Presentation] エクルーシス試薬を用いた多嚢胞性卵巣症候群の診断における血中LH/FSH比の基準値の検討2009

    • Author(s)
      木内理世, 他
    • Organizer
      第82回日本内分泌学会学術総会
    • Place of Presentation
      群馬県前橋市
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early life immune challenge affects the regulation of estrus cycle and feeding behavior in female rats.2009

    • Author(s)
      Iwasa T, et. al.
    • Organizer
      The Endocrine Society's 91^<st> Annual Meeting
    • Place of Presentation
      Washigton, DC, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Early life lipopolysaccharide expose attenuates the suppressive responses of LH serection to homotypic immune challenge in adulthood in male rat2009

    • Author(s)
      Matsuzaki T, et. al.
    • Organizer
      The Endocrine Society's 91^<st> Annual Meeting
    • Place of Presentation
      Washigton, DC, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 雄ラットにわいて新生仔期の感染ストレスは成熟後の感染ストレスに対する性機能の反応を視床下部で減弱させる2009

    • Author(s)
      岩佐武, 他
    • Organizer
      第62回日本産科婦人科学会中国四国合同地方部会総会
    • Place of Presentation
      鳥取県米子市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 雌ラットにおいて新生仔期の感染ストレスは成熟後の感染ストレスに対する性機能および摂食調節機構の反応に相反する影響を与える2009

    • Author(s)
      藤澤しのぶ, 他
    • Organizer
      第62回日本産科婦人科学会中国四国合同地方部会総会
    • Place of Presentation
      鳥取県米子市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多胎妊娠、OHSSの最近の動向とゴナドトロピン療法の在り方2009

    • Author(s)
      松崎利也
    • Organizer
      第54回日本生殖医学会・学術集会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2009 Annual Research Report
  • [Presentation] 雌ラットにおける絶食時のKiSS-lmRNAの発現変化2009

    • Author(s)
      岩佐武, 他
    • Organizer
      第54回日本生殖医学会・学術講演会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2009 Annual Research Report
  • [Presentation] エクルーシスを用いた多嚢胞性卵巣症候群における血中LH, LH/FSH比の検討2009

    • Author(s)
      木内理世, 他
    • Organizer
      第54回日本生殖医学会・学術講演会
    • Place of Presentation
      石川県金沢市
    • Related Report
      2009 Annual Research Report
  • [Book] 今日の診断指針第6版2010

    • Author(s)
      松崎利也, 他
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 産婦人科検査マニュアル2010

    • Author(s)
      松崎利也, 他4名
    • Total Pages
      232
    • Publisher
      診断と治療社
    • Related Report
      2010 Annual Research Report
  • [Book] 今日の診断指針第6版(金澤一郎、永井良造 編)2010

    • Author(s)
      松崎利也, 他
    • Total Pages
      2144
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] インフォームドコンセントのための図説シリーズ不妊症・不育症 改訂版2009

    • Author(s)
      松崎利也, 他
    • Total Pages
      99
    • Publisher
      医薬ジャーナル社
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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