Rhythm formation of fetal brain function and effect of maternal environmental stress

• Project/Area Number: 21592103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Miyazaki
• Principal Investigator: IKENOUE Tsuyomu 宮崎大学, 理事 (60232211)
• Co-Investigator(Kenkyū-buntansha): TATSUMOTO Shin 宮崎大学, 教育文化学部, 准教授 (50279965)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 胎児脳機能 / active and inactive state / リズム形成 / 中大脳動脈血流速度 / 神経学的発達 / 心理学的検査

Research Abstract

Based on the observation of fetal heart rate pattern, two different states of brain functions are differentiated. These 2 different states appear one after another with some rhythmic cycle. This phenomenon is considered to represent the functional changes of the fetal brain.
We have revealed that normally developing fetus obtains the rhythmic cycle at 33 weeks of gestation whereas the intrauterine growth restricted fetus delays it significantly.(fig. 1)
The middle cerebral artery Doppler velocimetry during active state varies more than that of during non active state significantly.(fig. 2)
We finished the tests of rhythm formation on 143 fetuses and will completed the developmental psychological examination at the age of 3.

Research Products

• [Presentation] 胎児心拍数モニタリングにおけるcyclic changeと脳血流との関連 (2010)
  • Author(s): 住吉香恵子、川越靖之、鮫島浩、池ノ上克
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2010-04-23
• [Presentation] 胎児心拍数モニタリングにおけるリズム形成時期と幼児期の発達との関連 (2009)
  • Author(s): 住吉香恵子、川越靖之、鮫島浩、池ノ上克
  • Organizer: 第14回九州小児・体外循環研究会
  • Place of Presentation: 霧島いわさきホテル
  • Year and Date: 2009-09-05
• [Presentation] 胎児心拍数モニタリングを用いたリズム形成時期と幼児期の発達との関連 (2009)
  • Author(s): 住吉香恵子、川越靖之、岩砂智丈、鮫島浩、池ノ上克
  • Organizer: 第61回日本産科婦人科学会学術講演会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2009-04-04