Gene mutations flanking tumor-related genes associated with malignant transformation of ovarian endometriosis
| Project/Area Number |
21592104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KITAWAKI Jo 京都府立医科大学, 医学研究科, 教授 (00204925)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 子宮内膜症 / 悪性転化 / 卵巣癌 / loss of heterozygosity / 癌抑制遺伝子 |
|---|
| Research Abstract |
Although ovarian endometriosis follows a benign course, the frequency of the malignant transformation of endometrioma is estimated at about 0.7-1.6%. Here we detected totally 31 loss of heterozygosity events in endometriosis, transitional and carcinoma tissues. Immunohistochemistry revealed that only aromatase was differentially expressed between endometriosis and carcinoma tissues. Our study suggested that LOH in some candidate gene loci may be involved in malignant transformation of endometriosis.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] 17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-302011
Author(s)
Fukui M, Senmaru T, Hasegawa G, Yamazaki M, Asano M, Kagami Y, Ishigami A, Maruyama N, Iwasa K, Kitawaki J, Itoh Y, Okanoue T, Ohta M, Obayashi H, Nakamura N
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Journal Title
Biochem Biophys Res Commun
Volume: 415
Issue: 2
Pages: 252-257
DOI
Related Report
Peer Reviewed
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[Journal Article] The fatty acid composition of plasma cholesteryl esters and estimated desaturase activities in patients with nonalcoholic fatty liver disease and the effect of long-term ezetimibe therapy on these levels2010
Author(s)
Park H, Hasegawa G, Shims. T, Fukui M, Nakamura N, Yamaguchi K, Mitsuyoshi H, Minami M, Yasui K, Itoh Y, Yoshikawa T, Kitawaki J, Ohta M, Obayashi H, Okanoue T.
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Journal Title
Clin Chim Acta
Volume: 411
Pages: 1735-1740
Related Report
Peer Reviewed
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