| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Although ovarian endometriosis follows a benign course, the frequency of the malignant transformation of endometrioma is estimated at about 0.7-1.6%. Here we detected totally 31 loss of heterozygosity events in endometriosis, transitional and carcinoma tissues. Immunohistochemistry revealed that only aromatase was differentially expressed between endometriosis and carcinoma tissues. Our study suggested that LOH in some candidate gene loci may be involved in malignant transformation of endometriosis.
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