The relationships of Chlamydia Trachomatis heaatshock protein 60 resulting in tubal damage
| Project/Area Number |
21592107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
HIRANO Yuki 自治医科大学, 医学部, 助教 (10398521)
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| Co-Investigator(Kenkyū-buntansha) |
SHIBAHARA Hiroaki 自治医科大学, 医学部, 教授 (80206143)
SHIMADA Kazuhiko 自治医科大学, 医学部, 助教 (60424024)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | クラミジア・トラコマティス / 卵管性不妊症 / クラミジアHSP60 / クラミジア感染 / TLR(toll like receptor) / HMGB1 (High Mobility Group Box 1) / クラミジア・トラコマティス感染症 / 抗精子抗体 / 熱ショック蛋白60 / 免疫性不妊症 |
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| Research Abstract |
We established tubal factor infertility model mouse by chlamydia trachomatis infection, and recognized with the rise of anti-chlamydial heat shock protein 60(cHSP60) antibody titer and also with the rise of anti-Ct antibody titer.
Moreover, we tried the secondary infection supposing a delayed type hypersensitivity reaction in order to produce a more advanced damage infertility model mouse.
As a result, by the secondary infection model, since more advanced tubal damage was accepted and it went up to also about anti-Ct antibody titer and anti-cHSP60 antibody titer as compared with the group of only initial infection.
Thus, cHSP60 may be mainly involved in the delayed hypersensitive response resulting in tubal damage
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Report
(4 results)
Research Products
(18 results)
