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Cadherin-mediated reconstitution mechanism of human endometrial epithelial cells during implantation研究代表者:

Research Project

Project/Area Number 21592108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

UCHIDA Hiroshi  慶應義塾大学, 医学部, 助教 (90286534)

Co-Investigator(Kenkyū-buntansha) MARUYAMA Tetsuo  慶應義塾大学, 医学部, 講師 (10209702)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords生殖医学 / 着床 / カドヘリン / 上皮間充織転換 / 組織再構築
Research Abstract

Human endometrial epithelial cell(EEC) layer, which is structural and immunological barrier, is temporally disrupted by penetration of fertilized egg in the process of pregnancy, however the reconstruction mechanism of disrupted EEC layer is largely unknown. This study demonstrated that epithelial mesenchymal transition is involved in the mechanism in association with redistribution of N-cadherin. These results are useful for the new strategy of assisted reproductive technology.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2012 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 13 results) Presentation (16 results)

  • [Journal Article] Involvement of epithelial mesenchymal transition of human endometrial epithelial cells in human embryo implantation : evidence from studies using in vitro model2012

    • Author(s)
      Uchida H, Maruyama T, Nishikawa-Uchida S, Oda H, Miyazaki K, Yamasaki A, Yoshimura Y
    • Journal Title

      J Biol Chem

      Volume: 287 Pages: 4441-4450

    • Related Report
      2011 Final Research Report
  • [Journal Article] Psychological adjustment and psychosocial stress among Japanese couples with a history of recurrent pregnancy loss2012

    • Author(s)
      Kagami M, Maruyama T, Koizumi T, Miyazaki K, Nishikawa-Uchida S, Oda H, Uchida H, Fujisawa D, Ozawa N, Schmidt L, Yoshimura Y
    • Journal Title

      Hum Reprod

      Volume: 27 Pages: 787-794

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of epithelial mesenchymal transition of human endometrial epithelial cells in human embryo implantation : evidence from studies using in vitro model2012

    • Author(s)
      H.Uchida, T.Maruyama, S.Nishikawa-Uchida, H.Oda, K.Miyazaki, A.Yamasaki, Y.Yoshimura
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Issue: 7 Pages: 4441-4450

    • DOI

      10.1074/jbc.m111.286138

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psychological adjustment and psychosocial stress among Japanese couples with a history of recurrent pregnancy loss2012

    • Author(s)
      M.Kagami, T.Maruyama, T.Koizumi, K.Miyazaki, S.Nishikawa-Uchida, H.Oda, H.Uchida, D.Fujisawa, N.Ozawa, L.Schmidt, Y.Yoshimura
    • Journal Title

      Human Reproduction

      Volume: 27 Issue: 3 Pages: 787-794

    • DOI

      10.1093/humrep/der441

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OCT4 expression in human uterine myometrial stem/progenitor cells2010

    • Author(s)
      Ono M, Kajitani T, Uchida H, Arase T, Oda H, Nishikawa-Uchida S, Masuda H, Nagashima T, Yoshimura Y, Maruyama T
    • Journal Title

      Hum Reprod

      Volume: 25 Pages: 2059-2067

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell-like properties of the endometrial side population : implication in endometrial regeneration2010

    • Author(s)
      Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
    • Journal Title

      PLoS One

      Volume: 5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stem cell-like properties of the endometrial side population : implication in endometrial regeneration.2010

    • Author(s)
      Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
    • Journal Title

      PLoS One.

      Volume: 5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OCT4 expression in human uterine myometrial stem/progenitor cells.2010

    • Author(s)
      Ono M, Kajitani T, Uchida H, Arase T, Oda H, Nishikawa-Uchida S, Masuda H, Nagashima T, Yoshimura Y, Maruyama T
    • Journal Title

      Hum Reprod.

      Volume: 25 Pages: 2059-2067

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Treatment in Assisted Human Embryo Implantation2009

    • Author(s)
      Uchida H, Maruyama T, Kagami M, Oda H, Nishikawa S, Kajitani T, Asada H, Yoshimura Y
    • Journal Title

      J Mam Ova Res

      Volume: 26 Pages: 116-121

    • NAID

      130004436751

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-82009

    • Author(s)
      Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
    • Journal Title

      J Immunol

      Volume: 182 Pages: 7074-7084

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns2009

    • Author(s)
      Sugawa F, Wada Y, Maruyama T, Uchida H, Ishizuka B, Ogata T
    • Journal Title

      Fertil Steril

      Volume: 91 Pages: 649-652

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic Treatment in Assisted Human Embryo Implantation2009

    • Author(s)
      Uchida H, Maruyama T, Kagami M, Oda H, Nishikawa S, Kajitani T, Asada H, Yoshimura Y
    • Journal Title

      J.Mamm.Ova Res 26

      Pages: 116-121

    • NAID

      130004436751

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The UDP-glucose recepter P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-82009

    • Author(s)
      Arase T, Uchida H, Kajitani T, Ono M, Tamaki K, Oda H, Nishikawa S, Kagami M, Nagashima T, Masuda H, Asada H, Yoshimura Y, Maruyama T
    • Journal Title

      J Immunol 182

      Pages: 7074-7084

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Premature ovarian failure and androgen receptor gnen CAG repeat lengths weighted by X chromosome inactivation patterns2009

    • Author(s)
      Sugawa F, Wada Y, Maruyama T, Uchida H, Ishizuka B, Ogata T
    • Journal Title

      Fertil Steril 91

      Pages: 649-652

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト着床における子宮内膜上皮の細胞死によらない新たな胚陥入促進機序-N-cadherin依存性細胞運動-2011

    • Author(s)
      内田浩, 丸山哲夫, 内田明花, 山崎彰子, 宮崎薫, 吉村泰典
    • Organizer
      第16回日本生殖内分泌学会学術総会
    • Year and Date
      2011-11-19
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト着床における子宮内膜上皮の細胞死によらない新たな胚陥入促進機序-N-cadher in依存性細胞運動-2011

    • Author(s)
      内田浩
    • Organizer
      第16回日本生殖内分泌学会学術総会
    • Place of Presentation
      東京都千代田区・シェーンバッハ・サボー
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Epithelial-mesenchymal transition mediates the displacement of endometrial epithelial cells away from the site of embryo implantation.2011

    • Author(s)
      Uchida H, Maruyama T, Uchida-Nishikawa, S, Miyazaki K, Yoshimura Y
    • Organizer
      World Congress of Reproductive Biology.
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト着床モデルにおける胚伸展のための子宮内膜上皮動態の分子機序解析-Rho family低分子量Gタンパク質の機能関与-2011

    • Author(s)
      内田浩, 丸山哲夫, 内田明花, 小田英之, 宮崎薫, 各務真紀, 青木大輔, 吉村泰典
    • Organizer
      第63回日本産科婦人科学会総会・学術講演会
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト着床における子宮内膜上皮細胞動態-卵巣ホルモンと低分子量Gタンパク質の関与-2011

    • Author(s)
      内田浩, 丸山哲夫, 西川明花, 小田英之, 宮崎薫, 各務真紀, 吉村泰典
    • Organizer
      第84回日本内分泌学会学術総会
    • Related Report
      2011 Final Research Report
  • [Presentation] Epithelial-mesenchymal transition mediates the displacement of endometrial epithelial cells away from the site of embryo implantation2011

    • Author(s)
      H.Uchida
    • Organizer
      2011 World Congress of Reproductive Biology
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト着床における子宮内膜上皮細胞動態-卵巣ホルモンと低分子量Gタンパク質の関与-2011

    • Author(s)
      内田浩
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      兵庫県神戸市・神戸国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト着床モデルにおける胚伸展のための子宮内膜上皮動態の分子機序解析-Rho family低分子量Gタンパク質の機能関与-2011

    • Author(s)
      内田浩
    • Organizer
      第63回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      大阪府大阪市・大阪国際会議場
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト着床における子宮内膜腺上皮の複合的機能の分子制御2010

    • Author(s)
      内田浩
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト着床におけるN-cadherinによるホルモン依存的子宮内膜腺上皮細胞層の再構築2010

    • Author(s)
      内田浩, 丸山哲夫, 小田英之, 西川明花, 梶谷宇, 宮崎薫, 各務真紀, 吉村泰典
    • Organizer
      第83回日本内分泌学会学術総会
    • Related Report
      2011 Final Research Report
  • [Presentation] N-Cadherin and RhoA Have Opposite Effects on the Regulation of Endometrial Epithelial Cell Migration during Implantation2010

    • Author(s)
      Uchida H, Maruyama T, Arase, T, Ono M, Kajitani, T, Kagami, M, Oda, H, Nishikawa, S, Yoshimura Y
    • Organizer
      57th Society for Gynecologic Investigation
    • Place of Presentation
      Orland, Florida, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 【シンポジウム 子宮内膜の機能調節とその病態】ヒト着床における子宮内膜腺上皮の複合的機能の分子制御2010

    • Author(s)
      内田浩
    • Organizer
      第62回日本産科婦人科学会
    • Place of Presentation
      東京(招請講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト着床における子宮内膜腺上皮細胞とグリコデリン2009

    • Author(s)
      内田浩
    • Organizer
      日本ヒト細胞学会
    • Year and Date
      2009-08-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 着床時子宮内膜腺上皮のダイナミクスと分子制御2009

    • Author(s)
      内田浩
    • Organizer
      第27回日本受精着床学会総会・学術講演会
    • Year and Date
      2009-08-07
    • Related Report
      2011 Final Research Report
  • [Presentation] 着床時子宮内膜腺上皮のダイナミクスと分子制御2009

    • Author(s)
      内田浩
    • Organizer
      第27回日本受精着床学会
    • Place of Presentation
      東京都港区・東京都慈恵医科大学
    • Related Report
      2009 Annual Research Report
  • [Presentation] 着床時子宮内膜腺上皮のダイナミクスと分子制御2009

    • Author(s)
      内田浩
    • Organizer
      第27回日本ヒト細胞学会
    • Place of Presentation
      京都府京都市・国立京都国際会館
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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