| Project/Area Number |
21592110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Tetuso 慶應義塾大学, 医学部, 講師 (10209702)
UCHIDA Hiroshi 慶應義塾大学, 医学部, 助教 (90286534)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 子宮内膜症 / 疼痛 / リポキシゲナーゼ / ロイコトリエン / リポキシン / 脂質メディエーター / リポキシゲナーゼ類 |
|---|
| Research Abstract |
The purpose of this research project was to elucidate the role of the lypoxygenase(LOX) and its signaling pathway in the pathogenesis and pathophysiology of endometriosis. We demonstrated that 5-LOX and 15-LOX mRNA were up-regulated in endometrioma compared to normal eutopic endometrium, whereas 12-LOX mRNA levels did not differ between them. These results collectively suggest that the LOX pathway may be, at least in part, involved in the pathophysiology of endometriosis. We have also developed several types of in vivo mouse model of endometrisois using severely immunodeficient mice as a research tool to explore the role of LOX and its signaling pathway in endometriosis.
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