| Project/Area Number |
21592114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
相澤 志保子 日本大学, 医学部, 助手 (30513858)
泉 泰之 日本大学, 医学部, 研究員 (50459872)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 習慣流産 / 免疫機序 / 寄生虫抗原 / Th17 / 寄生虫 / 免疫調節 / 衛生仮説 / マウスモデル |
|---|
| Research Abstract |
The mammalian fetuses are semi-allograft for mothers. Therefore the failure of immunological tolerance often causes pregnancy loss. We revealed therapeutic potential of the recombinant antigen from a nematoda parasite, Dirofilaria immitis rDiAg with a murine recurrent spontaneous abortion model.(CBA/J×DBA/2J) The rDiAg treatment significantly reduced the resorption rates of mouse model, which mimic human pregnancy failures with allo-immune backgrounds.
Serum IL-4, IL-23 and TNF-α concentrations were significantly lower in rDiAg-treated mice than mock-treated mice. The serum IL-17 level was also reduced in rDiAg-treated mice but the difference was not significant. Our observations suggest as the first time of therapeutic potentials of parasites for pregnancy loss.
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