Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion
| Project/Area Number |
21592114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
相澤 志保子 日本大学, 医学部, 助手 (30513858)
泉 泰之 日本大学, 医学部, 研究員 (50459872)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 習慣流産 / 免疫機序 / 寄生虫抗原 / Th17 / 寄生虫 / 免疫調節 / 衛生仮説 / マウスモデル |
|---|
| Research Abstract |
The mammalian fetuses are semi-allograft for mothers. Therefore the failure of immunological tolerance often causes pregnancy loss. We revealed therapeutic potential of the recombinant antigen from a nematoda parasite, Dirofilaria immitis rDiAg with a murine recurrent spontaneous abortion model.(CBA/J×DBA/2J) The rDiAg treatment significantly reduced the resorption rates of mouse model, which mimic human pregnancy failures with allo-immune backgrounds.
Serum IL-4, IL-23 and TNF-α concentrations were significantly lower in rDiAg-treated mice than mock-treated mice. The serum IL-17 level was also reduced in rDiAg-treated mice but the difference was not significant. Our observations suggest as the first time of therapeutic potentials of parasites for pregnancy loss.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis2010
Author(s)
Komine-Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, Haga S, Sugitani M, Honda M, Hayakawa S, Yamamoto S
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Journal Title
Clin Vaccine Immunol
Volume: 17(10)
Pages: 1500-6
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[Journal Article] Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis.2010
Author(s)
Komine-Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, Haga S, Sugitani M, Honda M, Hayakawa S, Yamamoto S
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Journal Title
Clin Vaccine Immunol.
Volume: 17
Pages: 1500-1506
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Author(s)
Shinojima Y, Terui T, Hara H, Kimura M, Igarashi J, Wang X, Kawashima H, Kobayashi Y, Muroi S, Hayakawa S, Esumi M, Fujiwara K, Ghosh S, Yamamoto T, Held W, Nagase H.
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Journal Title
J Dermatol Sci.
Volume: 59
Pages: 98-106
NAID
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[Journal Article] Guidelines for managing conscientious objection to blood transfusion2009
Author(s)
Ohto H, Yonemura Y, Takeda J, Inada E, Hanada R, Hayakawa S, Miyano T, Kai K, Iwashi W, Muto K, Asai F
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Journal Title
Transfus Med Rev.2009 Jul ; 23(3):221-8 23
Pages: 221-8
NAID
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[Journal Article] Subtyping and env C2/V3 sequence analysis of HIV-1 isolated from HIV-infected children hospitalized in Children Hospital 1, Vietnam during 2004-20052009
Author(s)
Trinh QD, Pham NT, Lam BQ, Le TP, Truong KH, Le TQ, Vo HT, Tang TC, Ha TM, Izumi Y, Mizuguchi M, Hayakawa S, Ushijima H.
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Journal Title
Journal of Tropical Pediatrics 55
Pages: 399-401
Related Report
Peer Reviewed
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