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Therapeutic potentials of parasitic antigens on a murine recurrent spontaneous abortion

Research Project

Project/Area Number 21592114
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNihon University

Principal Investigator

HAYAKAWA Satoshi  日本大学, 医学部, 教授 (30238084)

Co-Investigator(Kenkyū-buntansha) 相澤 志保子  日本大学, 医学部, 助手 (30513858)
泉 泰之  日本大学, 医学部, 研究員 (50459872)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords習慣流産 / 免疫機序 / 寄生虫抗原 / Th17 / 寄生虫 / 免疫調節 / 衛生仮説 / マウスモデル
Research Abstract

The mammalian fetuses are semi-allograft for mothers. Therefore the failure of immunological tolerance often causes pregnancy loss. We revealed therapeutic potential of the recombinant antigen from a nematoda parasite, Dirofilaria immitis rDiAg with a murine recurrent spontaneous abortion model.(CBA/J×DBA/2J) The rDiAg treatment significantly reduced the resorption rates of mouse model, which mimic human pregnancy failures with allo-immune backgrounds.
Serum IL-4, IL-23 and TNF-α concentrations were significantly lower in rDiAg-treated mice than mock-treated mice. The serum IL-17 level was also reduced in rDiAg-treated mice but the difference was not significant. Our observations suggest as the first time of therapeutic potentials of parasites for pregnancy loss.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 8 results) Presentation (7 results) Book (4 results)

  • [Journal Article] CBA/J×DBA/2J流産マウスモデルにおける"当帰芍薬散""柴苓湯"の効果2012

    • Author(s)
      相澤(小峯)志保子, 早川智
    • Journal Title

      産婦人科漢方研究の歩み

      Volume: 29

    • Related Report
      2011 Final Research Report
  • [Journal Article] The therapeutic potential of the recombinant antigen from Dirofilaria immitis(rDiAg) for immune-mediated pregnancy loss2011

    • Author(s)
      Komine-Aizawa S, Izumi Y, Imai S, Fujita K, Hayakawa S
    • Journal Title

      J Reprod Immunol

      Volume: 92(1-2) Pages: 21-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Lipo-polysaccharide(LPS)-induced Interferon(IFN)-gamma production by decidual mononuclear cells(DMNC) is interleukin(IL)-2 and IL-12 dependent2011

    • Author(s)
      Negishi M, Izumi Y, Aleemuzzaman S, Inaba N, Hayakawa S
    • Journal Title

      Am J Reprod Immunol

      Volume: 65(1) Pages: 20-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【母体と児の感染免疫-最新の知見】母体と児の免疫2011

    • Author(s)
      早川智
    • Journal Title

      妊婦における免疫の変化(臨床と微生物)

      Volume: 38巻6号 Pages: 631-636

    • Related Report
      2011 Final Research Report
  • [Journal Article] 【不育症最前線】感染症と不育症2011

    • Author(s)
      相澤志保子, 早川智
    • Journal Title

      産婦人科の実際

      Volume: 60巻10号 Pages: 1497-1501

    • Related Report
      2011 Final Research Report
  • [Journal Article] The therapeutic potential of the recombinant antigen from Dirofilaria immitis (rDiAg) for immune-mediated pregnancy loss2011

    • Author(s)
      Komine-Aizawa S, Izumi Y, Imai S, Fujita K, Hayakawa S
    • Journal Title

      J Reprod Immunol

      Volume: 92 Pages: 21-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipopolysaccharide (LPS)-induced Interferon (IFN)-gamma production by decidual mononuclear cells (DMNC) is interleukin (IL)-2 and IL-12 dependent.2011

    • Author(s)
      Negishi M, Izumi Y, Aleemuzzaman S, Inaba N, Hayakawa S.
    • Journal Title

      Am J Reprod Immunol.

      Volume: 65 Pages: 20-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【母体感染症Up to Date】総説 妊婦における免疫の変化2011

    • Author(s)
      早川智, 相澤志保子
    • Journal Title

      周産期医学

      Volume: 41 Pages: 154160-154160

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis2010

    • Author(s)
      Komine-Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, Haga S, Sugitani M, Honda M, Hayakawa S, Yamamoto S
    • Journal Title

      Clin Vaccine Immunol

      Volume: 17(10) Pages: 1500-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis.2010

    • Author(s)
      Komine-Aizawa S, Yamazaki T, Yamazaki T, Hattori S, Miyamoto Y, Yamamoto N, Haga S, Sugitani M, Honda M, Hayakawa S, Yamamoto S
    • Journal Title

      Clin Vaccine Immunol.

      Volume: 17 Pages: 1500-1506

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and analysis of an early diagnostic marker for malignant melanoma : ZAR1 intra-genic differential methylation.2010

    • Author(s)
      Shinojima Y, Terui T, Hara H, Kimura M, Igarashi J, Wang X, Kawashima H, Kobayashi Y, Muroi S, Hayakawa S, Esumi M, Fujiwara K, Ghosh S, Yamamoto T, Held W, Nagase H.
    • Journal Title

      J Dermatol Sci.

      Volume: 59 Pages: 98-106

    • NAID

      10027401820

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【妊娠免疫Update子宮内膜局所免疫と妊娠】Toll-like receptorの胎盤における機能2010

    • Author(s)
      相澤志保子, 早川智
    • Journal Title

      医学のあゆみ

      Volume: 233 Pages: 147-150

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Lipopolysaccharide(LPS)induced Interferon(IFN)-γ production by decidual mononuclear cells is Interleukin(IL)-2 and IL-12 dependent2010

    • Author(s)
      Masami Negishi M, Izumi Y, Inaba N, Hayakawa S
    • Journal Title

      American Journal of Reproductive Immunology (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] H3N2 influenza A virus replicates in immortalized human first trimester trophoblast cell lines and induces their rapid apoptosis2009

    • Author(s)
      Trinh QD, Izumi Y, Komine-Aizawa S, Shibata T, Shimotai Y, Kuroda K, Mizuguchi M, Ushijima H, Mor G, Hayakawa S.
    • Journal Title

      American Journal of Reproductive Immunology 62

      Pages: 139-146

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for managing conscientious objection to blood transfusion2009

    • Author(s)
      Ohto H, Yonemura Y, Takeda J, Inada E, Hanada R, Hayakawa S, Miyano T, Kai K, Iwashi W, Muto K, Asai F
    • Journal Title

      Transfus Med Rev.2009 Jul ; 23(3):221-8 23

      Pages: 221-8

    • NAID

      120002190599

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subtyping and env C2/V3 sequence analysis of HIV-1 isolated from HIV-infected children hospitalized in Children Hospital 1, Vietnam during 2004-20052009

    • Author(s)
      Trinh QD, Pham NT, Lam BQ, Le TP, Truong KH, Le TQ, Vo HT, Tang TC, Ha TM, Izumi Y, Mizuguchi M, Hayakawa S, Ushijima H.
    • Journal Title

      Journal of Tropical Pediatrics 55

      Pages: 399-401

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【生殖器の感染防御機構】女性生殖器における感染防御機構 オーバービュー2009

    • Author(s)
      早川智
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY 16

      Pages: 295-299

    • Related Report
      2009 Annual Research Report
  • [Presentation] CBA/J×DBA/2J反復流産マウスモデルに対する新たな治療戦略と免疫学的解析2012

    • Author(s)
      相澤(小峯)志保子, 早川智
    • Organizer
      第64回日本産科婦人科学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] CBA/J×DBA/2J流産マウスモデルにおける"当帰芍薬散""柴苓湯"の効果2011

    • Author(s)
      相澤(小峯)志保子, 早川智
    • Organizer
      第29回産婦人科漢方研究会
    • Place of Presentation
      徳島
    • Related Report
      2011 Final Research Report
  • [Presentation] 流産マウスモデルにおける新しい流産予防治療の開発2011

    • Author(s)
      相澤(小峯)志保子, 早川智
    • Organizer
      第26回日本生殖免疫学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] Mucosal immune response and pregnancy : a possible role of placental barrier2010

    • Author(s)
      Satoshi Hayakawa
    • Organizer
      The 1^<st> congress of APSIGO(Asia Pacific Congress of Infectious diseases of gynecology and obstetrics
    • Place of Presentation
      Singapore(招待講演)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] The therapeutic potential of the recombinant antigen from Dirofilaria immitis(rDiAg) for immune mediated pregnancy loss2010

    • Author(s)
      Shihoko Komine-Aizawa, Yasuyuki Izumi, and Satoshi Hayakawa
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] The therapeutic potential of the recombinant antigen from Dirofilaria immitis (rDiAg) for immune mediated pregnancy loss2010

    • Author(s)
      Shihoko Komine-Aizawa, Yasuyuki Izumi, Satoshi Hayakawa
    • Organizer
      14th International Congress of Immunology. Workshop
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Th1サイトカインはヒト脱落膜リンパ球のLPS感受性を亢進する2009

    • Author(s)
      根岸正実, 泉泰之, 大島教子, 稲葉憲之, 早川智
    • Organizer
      第37回日本臨床免疫学会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Book] 今日の治療指針,妊婦の感染症2011

    • Author(s)
      山口徹
    • Publisher
      医学書院
    • Related Report
      2011 Final Research Report
  • [Book] 今日の治療指針(山口徹, 他編)2011

    • Author(s)
      早川智(分担執筆)
    • Total Pages
      1978
    • Publisher
      医学書院
    • Related Report
      2010 Annual Research Report
  • [Book] 臨床粘膜免疫,産婦人科領域2010

    • Author(s)
      清野宏
    • Publisher
      シナジー
    • Related Report
      2011 Final Research Report
  • [Book] 臨床粘膜免疫学(清野宏編著)2010

    • Author(s)
      早川智(分担執筆)
    • Total Pages
      736
    • Publisher
      シナジー
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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