| Project/Area Number |
21592115
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Obstetrics and gynecology
|
|---|
| Research Institution | Nippon Medical School |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Osamu 日本医科大学, 医学部, 講師 (70293214)
TAKESHITA Toshiyuki 日本医科大学, 大学院・医学研究科, 教授 (60188175)
TAKIZAWA Toshihiro 日本医科大学, 大学院・医学研究科, 教授 (90271220)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 婦人科学 / 卵巣 / 卵胞 / 莢膜細胞 / 多嚢胞性卵巣症候群 / microRNA |
|---|
| Research Abstract |
We performed miRNA profiling of isolated mouse thecal stem cells from neonatal mouse ovary and in vitro differentiating theca cells. We investigated differential miRNA signatures between thecal stem cells and differentiating cells by real-time PCR-based miRNA array analysis. During theca cell differentiation, 30 miRNAs were upregulated, and 9 miRNAs were downregulated. Ingenuity pathway analysis indicates that these miRNAs participate in reproductive system disease, genetic disorder, cellular development, cellular growth and proliferation, and cell cycles.
|
