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The effects of endocrine and immunological factors in reproductive medicine

Research Project

Project/Area Number 21592118
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKawasaki Medical School

Principal Investigator

SHIMOYA Koichiro  川崎医科大学, 医学部, 教授 (40291950)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Takafumi  川崎医科大学, 医学部, 教授 (20303969)
NAKAI Yuichiro  川崎医科大学, 医学部, 准教授 (50271193)
FUKE Shinji  川崎医科大学, 医学部, 講師 (50333696)
KAKU Shoji  川崎医科大学, 医学部, 講師 (50464178)
USHIODA Norichika  川崎医科大学, 医学部, 講師 (40454821)
CHANG Yang-sil  川崎医科大学, 医学部, 講師 (70565910)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords早産 / 子宮内感染 / fractalkine / 6Ckine / 酸化ストレス / 母体ストレス / 着床 / 子宮内感染(絨毛羊膜炎) / Fractalkine / 6 Ckine / 卵胞 / 体外受精・胚移植 / 妊娠高血圧症候群 / RCASI / 唾液中ストレスマーカー / RCAS1 / CRP / 炎症
Research Abstract

Various immunosuppressive factors, such as RCAS1 were associated with neonatal complications, such as preterm birth and preeclampsia. Products of oxidative stress, such as HNE had direct effects on uterine contraction. Cytokines, such as fractalkine and 6Ckine were associated with preterm birth and chorioamnionitis. These results suggested that lymphocytes, NK cells and dendritic cells were activated in chorioamnionitis. Maternal stress was associated with implantation success rate. The titration of salivary cortisol concentrations and chromogranin A/protein levels is a useful tool to determine maternal stress levels. The elevation of cortisol and chromogranin A/protein in the saliva was suppressed in the chronic high stress group during pregnancy. Maternal health without stress was important for pregnant women.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (30 results)

All 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 16 results) Presentation (9 results) Book (3 results)

  • [Journal Article] Effects of 4-Hydroxy-2-Nonenal, a Major Lipid Peroxidation-Derived Aldehyde, and N-Acetylcysteine on the Cyclooxygenase-2 Expression in Human Uterine Myometrium2011

    • Author(s)
      K Temma-Asano, Shimoya K, et al.
    • Journal Title

      Gynecol Obstet Invest

      Volume: 72(1) Pages: 37-42

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change of the salivary stress marker concentrations during pregnancy2011

    • Author(s)
      H Tsubouchi, Shimoya K, et al.
    • Journal Title

      Maternal depressive status suppress the changes of those levels

      Volume: 37(8) Pages: 1004-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change of the salivary stress marker concentrations during pregnancy : Maternal depressive status suppress the changes of those levels2011

    • Author(s)
      Hiroaki Tsubouchi, et al.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(8) Pages: 1004-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 糖代謝異常妊婦の治療に伴う身体、心理、社会的体験と治療に関する実態調査糖代謝異常妊婦への聞き取り調査から2011

    • Author(s)
      佐原玉恵, 他
    • Journal Title

      母性衛生

      Volume: 52巻 Pages: 78-90

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クリニカルカンファランス周産期科学的な視点から分娩の生理と病理を探る子宮収縮の生理と病理2011

    • Author(s)
      下屋浩一郎
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 63巻 Pages: 244-250

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 助産師による糖代謝異常妊婦への保健指導内容の検討糖代謝異常妊婦への質問紙による実態調査から2011

    • Author(s)
      佐原玉恵, 他
    • Journal Title

      糖尿病と妊娠

      Volume: 11巻 Pages: 127-133

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 選択的帝王切開分娩の適切な手術予定時期の検討2011

    • Author(s)
      張良実
    • Journal Title

      産婦人科の実際

      Volume: 60巻 Pages: 939-945

    • NAID

      40017106476

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Effects of 4-Hydroxy-2-Nonenal, a Major Lipid Peroxidation-Derived Aldehyde, and N-Acetylcysteine on the Cyclooxygenase-2 Expression in Human Uterine Myometrium.2011

    • Author(s)
      Temma-Asano K
    • Journal Title

      Gynecol Obstet Invest.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of tumor-associated protein RCAS1 gene silencing on bloodpressure and urinary protein excretion in pregnant mouse : a pilot study2010

    • Author(s)
      Tskitishvili E, Shimoya K, et al.
    • Journal Title

      Am J Obstet Gynecol

      Volume: 203(4) Pages: 6-12

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Maternal blood serum and plasma human tumor-associated antigen RCAS1 during the course of uncomplicated pregnancies : a prospective study2010

    • Author(s)
      Tskitishvili E, Shimoya K, et al.
    • Journal Title

      Am J Reprod Immunol

      Volume: 64(3) Pages: 218-32

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage : a preliminary study2010

    • Author(s)
      Kinugasa-Taniguchi Y, Shimoya K, et al.
    • Journal Title

      Reprod Sci

      Volume: 17(5) Pages: 419-25

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of tumor-associated protein RCAS1 gene silencing on blood pressure and urinary protein excretion in pregnant mouse : a pilot study.2010

    • Author(s)
      Tskitishvili E
    • Journal Title

      Am J Obstet Gynecol.

      Volume: 203(4)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maternal blood serum and plasma human tumor-associated antigen RCAS1 during the course of uncomplicated pregnancies : a prospective study.2010

    • Author(s)
      Tskitishvili E
    • Journal Title

      Am J Reprod Immunol

      Volume: 64(3) Pages: 218-24

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case report of sigmoid colon cancer during pregnancy.2010

    • Author(s)
      Yang-Sil Chang
    • Journal Title

      Kawasaki Medical Journal

      Volume: 36(3) Pages: 209-212

    • NAID

      110007721923

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage : a preliminary study.2010

    • Author(s)
      Kinugasa-Taniguchi Y
    • Journal Title

      Reprod Sci

      Volume: 17(5) Pages: 419-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells2010

    • Author(s)
      Tskitishvili E
    • Journal Title

      Mol Hum Reprod 16(3)

      Pages: 188-99

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Temporal and spatial expression of tumor-associated antigen RCAS1 in pregnant mouse uterus2010

    • Author(s)
      Tskitishvili E
    • Journal Title

      Am J Reprod Immunol 63(2)

      Pages: 137-43

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human C-reactive protein enhances vulnerability of immature rats to hypoxic-ischemic brain damage : a preliminary study2010

    • Author(s)
      Kinugasa-Taniguchi Y
    • Journal Title

      Reprod Sci. 17(5)

      Pages: 419-25

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠と免疫グロブリン-血小板減少などの合併症を中心に-2011

    • Author(s)
      下屋浩一郎
    • Organizer
      第1回周産期血液・免疫研究会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 合併症を有する女性の不妊治療・周産期医療2011

    • Author(s)
      下屋浩一郎
    • Organizer
      第91回北海道医学大会産婦人科分科会
    • Place of Presentation
      旭川
    • Year and Date
      2011-10-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 科学的な視点から分娩の生理と病理を探る子宮収縮の生理と病理2011

    • Author(s)
      下屋浩一郎
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 母体ならびに胎児におけるFractalkine/CX3CL1(FRK)の動態の解析2011

    • Author(s)
      張良実, 他
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 母体ならびに胎児におけるFractalkine/CX3CL1 (FRK)の動態の解析2011

    • Author(s)
      張良実
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 母子関係に影響する不妊治療に対する一般市民のアクセス性の現況2011

    • Author(s)
      中井祐一郎
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 周産期領域におけるFractalkine/CX3CL1の動態の解析2011

    • Author(s)
      張良実, 他
    • Organizer
      第47回日本周産期・新生児医学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-11
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 着床とストレスとの関連について-母体ストレスレベルは着床と相関する-2009

    • Author(s)
      潮田まり子
    • Organizer
      日本ストレス学会
    • Place of Presentation
      横浜市
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 体外受精-胚移植における着床とストレスとの関連について 唾液中コルチゾールは着床と相関する2009

    • Author(s)
      潮田まり子
    • Organizer
      日本生殖医学会
    • Place of Presentation
      金沢市
    • Year and Date
      2009-09-23
    • Related Report
      2009 Annual Research Report
  • [Book] 産婦人科レビュー生殖医療内科疾患と生殖2011

    • Author(s)
      下屋浩一郎
    • Publisher
      鍬谷書店
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 性感染症と生殖器感染(女性)2011

    • Author(s)
      下屋浩一郎
    • Total Pages
      317
    • Publisher
      診断と治療社
    • Related Report
      2011 Annual Research Report
  • [Book] 標準産科婦人科学第4版2011

    • Author(s)
      下屋浩一郎
    • Total Pages
      626
    • Publisher
      医学書院
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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