| Project/Area Number |
21592118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Takafumi 川崎医科大学, 医学部, 教授 (20303969)
NAKAI Yuichiro 川崎医科大学, 医学部, 准教授 (50271193)
FUKE Shinji 川崎医科大学, 医学部, 講師 (50333696)
KAKU Shoji 川崎医科大学, 医学部, 講師 (50464178)
USHIODA Norichika 川崎医科大学, 医学部, 講師 (40454821)
CHANG Yang-sil 川崎医科大学, 医学部, 講師 (70565910)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 早産 / 子宮内感染 / fractalkine / 6Ckine / 酸化ストレス / 母体ストレス / 着床 / 子宮内感染(絨毛羊膜炎) / Fractalkine / 6 Ckine / 卵胞 / 体外受精・胚移植 / 妊娠高血圧症候群 / RCASI / 唾液中ストレスマーカー / RCAS1 / CRP / 炎症 |
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| Research Abstract |
Various immunosuppressive factors, such as RCAS1 were associated with neonatal complications, such as preterm birth and preeclampsia. Products of oxidative stress, such as HNE had direct effects on uterine contraction. Cytokines, such as fractalkine and 6Ckine were associated with preterm birth and chorioamnionitis. These results suggested that lymphocytes, NK cells and dendritic cells were activated in chorioamnionitis. Maternal stress was associated with implantation success rate. The titration of salivary cortisol concentrations and chromogranin A/protein levels is a useful tool to determine maternal stress levels. The elevation of cortisol and chromogranin A/protein in the saliva was suppressed in the chronic high stress group during pregnancy. Maternal health without stress was important for pregnant women.
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