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The role of micro-RNA in carcinogenesis and development of uterine papillary serous carcinoma(UPSC)

Research Project

Project/Area Number 21592120
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionTohoku University

Principal Investigator

NAGASE Satoru  東北大学, 大学院・医学系研究科, 准教授 (00292326)

Co-Investigator(Kenkyū-buntansha) 大槻 健郎  東北大学, 病院, 助教 (40531330)
岡本 聡  東北大学, 病院, 臨床検査技師 (40420020)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords子宮体癌 / 子宮体部漿液性腺癌 / 類内膜腺癌 / マイクロRNA / 発現プロファイル / 子宮体がん / 標的遺伝子
Research Abstract

We compared miRNA expression levels in uterine papillary serous carcinoma (UPSC)with the levels in endometrial endometrioid adenocarcinoma (EEC)and normal endometria. Eight miRNAs were identified as having aberrant down-regulation specific to UPSC with miR-34b being most pronounced. Ectopic expression of miR-34b inhibited cell growth, migration, and most notably invasion. These effects are likely mediated by the downstream target of miR-34b, the proto-oncogene MET, a known prognostic factor in endometrial carcinomas. The expression of MET was reduced following the restoration of miR-34b in cell lines. In summary, our data suggest that miR-34b plays a role in the molecular pathogenesis of ESC.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma2011

    • Author(s)
      Hiroki E, Suzuki F, Akahira J, Nagase S, Ito K, Sugawara J, Miki Y, Suzuki T, Sasano H, Yaegashi N
    • Journal Title

      Int J Cancer

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 婦人科がんのMolecular Biology~72011

    • Author(s)
      鈴木史彦, 永瀬智
    • Journal Title

      エピジェネティクス

      Volume: 78 Pages: 67-73

    • Related Report
      2011 Final Research Report
  • [Journal Article] MicroRNA-34b functions as a potential tumor suppressor in endometrial serous adenocarcinoma2011

    • Author(s)
      Eri Hiroki, Fumihiko Suzuki, Jun-ichi Akahira, Satoru Nagase, Kiyoshi Ito, Jun-ichi Sugawara, Yasuhiro Miki, Takashi Suzuki, Hironobu Sasano, Nobuo Yaegashi
    • Journal Title

      International Journal of Cancer

      Volume: (Epud ahead of print)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 婦人科がんのMolecular Biology~7.エピジェネティクス2011

    • Author(s)
      鈴木史彦、永瀬智、八重樫伸生
    • Journal Title

      産科と婦人科

      Volume: 78 Pages: 67-73

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Japan Society of Gynecologic Oncology. Evidence-based guidelines for treatment of uterine body neoplasm in Japan : Japan Society of Gynecologic Oncology (JSGO)2009 edition2010

    • Author(s)
      Nagase S, 他28名
    • Journal Title

      Int J Clin Oncol

      Volume: 15 Pages: 531-542

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas2010

    • Author(s)
      Hiroki E, Akahira JI, Suzuki F, Nagase S, Ito K, Suzuki T, Sasano H, Yaegashi N
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 241-249

    • NAID

      10027200423

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas2010

    • Author(s)
      Eri Hiroki, Jun-ichi Akahira, Fumihiko Suzuki, Satoru Nagase, Kiyoshi Ito, Takashi Suzuki, Hironobu Sasano, Nobuo Yaegashi
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 241-249

    • NAID

      10027200423

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas.2010

    • Author(s)
      Hiroki E, Akahira J, Suzuki F, Nagase S, Ito K, Suzuki T, Sasano H, Yaegashi N.
    • Journal Title

      Cancer Sci. 101(1)

      Pages: 241-249

    • NAID

      10027200423

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮体部漿液性腺癌(UPSC)におけるmicroRNA-34bの発現制御および機能の解明2011

    • Author(s)
      鈴木史彦、永瀬智
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 子宮体部漿液性腺癌(UPSC)におけるマイクロRNAの発現異常および機能の検討2010

    • Author(s)
      永瀬智
    • Organizer
      Rare Tumor研究会(日本婦人科腫瘍学会)
    • Place of Presentation
      佐賀
    • Year and Date
      2010-12-05
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌においてmicroRNA-34bは癌抑制的な役割をもつ可能性がある2010

    • Author(s)
      廣木恵理、永瀬智
    • Organizer
      第69回日本癌学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌におけるマイクロRNAの役割2010

    • Author(s)
      鈴木史彦、永瀬智
    • Organizer
      第69回日本癌学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 子宮体部漿液性腺癌におけるマイクロRNAの役割2010

    • Author(s)
      鈴木史彦、永瀬智
    • Organizer
      第62回日本産婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas2009

    • Author(s)
      廣木恵理、永瀬智
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomas.2009

    • Author(s)
      廣木恵理
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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