The new molecular targeting therapy against the cancer stem cell in ovarian cancers
| Project/Area Number |
21592122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KURACHI Hirohisa 山形大学, 医学部, 教授 (40153366)
YOSHIDA Takayuki 山形大学, 医学部, 助教 (60466604)
TAKATA Keiko 山形大学, 医学部, 助教 (70375343)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌幹細胞 / Wilms' tumor 1 / 卵巣癌 / 薬剤耐性 / 分子標的治療 / yin and yang 1 |
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| Research Abstract |
We focused on the Wilms' tumor 1 (WT1) gene, which may be associated with the cancer stem cell in ovarian cancers. Short hairpin RNA (shRNA)-mediated stable downregulation of WT1, caused an epithelial-mesenchymal transition. We also demonstrated that WT1 could regulate HtrA1 and modulate cisplatin-mediated cytotoxicity using ovarian cancer cells transduced with WT1 shRNA.
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Report
(4 results)
Research Products
(16 results)
