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The new molecular targeting therapy against the cancer stem cell in ovarian cancers

Research Project

Project/Area Number 21592122
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionYamagata University

Principal Investigator

TSUYOSHI Ohta  山形大学, 医学部, 助教 (50375341)

Co-Investigator(Kenkyū-buntansha) KURACHI Hirohisa  山形大学, 医学部, 教授 (40153366)
YOSHIDA Takayuki  山形大学, 医学部, 助教 (60466604)
TAKATA Keiko  山形大学, 医学部, 助教 (70375343)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords癌幹細胞 / Wilms' tumor 1 / 卵巣癌 / 薬剤耐性 / 分子標的治療 / yin and yang 1
Research Abstract

We focused on the Wilms' tumor 1 (WT1) gene, which may be associated with the cancer stem cell in ovarian cancers. Short hairpin RNA (shRNA)-mediated stable downregulation of WT1, caused an epithelial-mesenchymal transition. We also demonstrated that WT1 could regulate HtrA1 and modulate cisplatin-mediated cytotoxicity using ovarian cancer cells transduced with WT1 shRNA.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (6 results) Remarks (2 results)

  • [Journal Article] Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells2012

    • Author(s)
      太田剛、高橋俊文、倉智博久
    • Journal Title

      Cancer Biology & Therapy

      Volume: 13 Pages: 25-33

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1alpha in human ovarian cancer cells2011

    • Author(s)
      Ohta T, Takahashi T, Shibuya T, Amita M, Henmi N, Takahashi K, Kurachi H.
    • Journal Title

      Cancer Biol Ther

      Volume: 13(1) Pages: 25-33

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011

    • Author(s)
      Takahashi K, Piao S, Yamatani H, Du B, Yin L, Ohta T, Kawagoe J, Takata K, Tsutsumi S, Kurachi H.
    • Journal Title

      Mol Cell Neurosci

      Volume: 48(3) Pages: 217-224

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Estrogen induces neurite outgrowth via Rho family GTPases in neuroblastoma cells2011

    • Author(s)
      高橋一広、太田剛、倉智博久
    • Journal Title

      Molecular Cell Neuroscience

      Volume: 48 Pages: 217-224

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of dienogest on estrogen-induced nitric oxide production in human umbilical vein endothelial cells and endothelium-dependent vasodilatation in postmenopausall women2010

    • Author(s)
      Henmi N, Takahashi K, Amita M, Takata K, Ohta T, Tsutsumi S, Takahashi T, Kurachi H.
    • Journal Title

      Menopose

      Volume: 17(3) Pages: 615-621

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mechanism of the inhibition of estradiol-induced endometrial epithelial cell proliferation by clomiphene citrate2010

    • Author(s)
      Amita M, Takahashi T, Tsutsumi S, Ohta T, Takata K, Henmi N, Hara S, Igarashi H, Takahashi K, Kurachi H.
    • Journal Title

      Endocrinology

      Volume: 151(1) Pages: 394-405

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome2009

    • Author(s)
      Ohta T, Isobe M, Takahashi T, Saitoh-Sekiguchi M, Motoyama T, Kurachi H.
    • Journal Title

      Anticancer Res

      Volume: 29(11) Pages: 4639-4647

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Akt and ERK activation by platinum-based chemotherapy in ovarian cancer is associated with favorable patient outcome.2009

    • Author(s)
      太田剛
    • Journal Title

      Anti-Cancer Research 29

      Pages: 4639-4647

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation of HtrA1 expression by WT1 is associated with chemosensitivity in ovarian cancer cells2011

    • Author(s)
      太田剛、倉智博久
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Flavopiridol-induced upregulation of HtrA1 is associated with suppression of its negative regulator WT1 and with enhanced chemosensitivity2011

    • Author(s)
      太田剛
    • Organizer
      米国癌学会(American Association for Cancer Research)
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2011-04-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Flavopiridol-induced upregulation of HtrA1 is associated with suppression of its negative transcriptional regulator WT1 and with enhanced chemosensitivity2011

    • Author(s)
      Ohta T, Khurana A, Maguire J, He X, Chien J, Bible K, Shridhar V.
    • Organizer
      AACR
    • Place of Presentation
      Orland, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌細胞におけるWT1によるHtrA1の制御機構と薬剤感受性の関連2011

    • Author(s)
      太田剛
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌細胞におけるHIF-1阻害によるシスプラチンの抗腫瘍効果増強作用についての検討2009

    • Author(s)
      太田剛
    • Organizer
      第61回日本産科婦人科学会学術講演会
    • Place of Presentation
      京都、国立京都国際会館
    • Year and Date
      2009-04-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 卵巣癌細胞におけるHIF-1阻害によるシスプラチンの抗腫瘍効果増強作用についての検討2009

    • Author(s)
      太田剛
    • Organizer
      第61回日本産科婦人科学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.id.yamagata-u.ac.jp/ObGyn/gyoseki_from2000.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.id.yamagata-u.ac.jp/ObGyn/gyoseki_from2000.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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