To investigate of anti-neoplastic effect of metformin in endometrial cancer

• Project/Area Number: 21592123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Chiba University
• Principal Investigator: MITSUHASHI Akira 千葉大学, 大学院・医学研究院, 准教授 (40302541)
• Co-Investigator(Kenkyū-buntansha): SHOZU Makio 千葉大学, 大学院・医学研究院, 教授 (30226302) ; USUI Hirokazu 千葉大学, 大学院・医学研究院, 講師 (90375634)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 子宮内膜癌 / メトホルミン

Research Abstract

1) The anti-neoplastic activity of metformin was observed in vitro and in vivo in endometrial cancer cell lines and in patients with endometrial cancer. Metformin appears to be a useful therapy in the prevention and treatment of patients with endometrial cancer.
2) The recurrence rate in our study was lower than that observed in the previous study. Metformin may inhibit endometrial cancer recurrence after MPA therapy. Metformin also improved insulin resistance in young endometrial cancer patients who were at risk of developing diabetes mellitus.

Research Products

• [Presentation] 低濃度メトフォルミンは、抗がん薬との併用で子宮体癌細胞に対し、相乗相加効果は示さない (2012)
  • Author(s): 植原貴史, 三橋暁, 他
  • Organizer: 第12回関東ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2012-01-19
• [Presentation] Metformin prevents recurrence following discontinuation of progestin therapy for fertility-sparing treatment in young women with endometrial cancer or atypical endometrial hyperplasia (2011)
  • Author(s): Akira Mitsuhashi, et al
  • Organizer: The 17^<th> International Meeting of the European Society of Gynecological Oncology
  • Place of Presentation: (ESGO)(イタリア・ミラノ)
  • Year and Date: 2011-09-13
• [Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験 (2011)
  • Author(s): 三橋暁
  • Organizer: 第63回日本産科婦人科学会
  • Place of Presentation: 大阪(招待講演)
  • Year and Date: 2011-08-30
• [Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験 (2011)
  • Author(s): 三橋暁, 他
  • Organizer: 第63回日本産科婦人科学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2011-08-29
• [Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験 (2011)
  • Author(s): 三橋暁, 他
  • Organizer: 第50回婦人科腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-22
• [Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験 (2011)
  • Author(s): 三橋暁
  • Organizer: 第50回婦人科腫瘍学会
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2011-07-22
• [Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験 (2011)
  • Author(s): 三橋暁, 他
  • Organizer: 第12回ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-07-15
• [Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験 (2011)
  • Author(s): 三橋暁
  • Organizer: 第12回ホルモンと癌研究会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2011-07-15
• [Presentation] The effect of metformin on cell proliferation in patients with endometrial cancer (2011)
  • Author(s): Akira Mitsuhashi, et al
  • Organizer: 2011 ASCO Annual Meeting
  • Place of Presentation: アメリカ・シカゴ
  • Year and Date: 2011-06-03
• [Presentation] The effect of metformin on cell proliferation in patients with endometrial cancer (2011)
  • Author(s): 三橋暁
  • Organizer: 2011 ASCO Annual Meeting
  • Place of Presentation: シカゴ(招待講演)
  • Year and Date: 2011-06-03
• [Presentation] 子宮体癌に対する内分泌療法 (2011)
  • Author(s): 三橋暁, 他
  • Organizer: 第11回関東ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-01-29
• [Presentation] Metformin prevents recurrence following discontinuation of progestin therapy for fertility-sparing treatment in young women with endometrial cancer or atypical endometrial hyperplasia (2011)
  • Author(s): 三橋暁
  • Organizer: The 17^<th> International Meeting of the European Society of Gynecological Oncology (ESGO)
  • Place of Presentation: ミラノ(招待講演)
• [Presentation] Metformin directly inhibits cell proliferation in endometrial cancer (2010)
  • Author(s): Akira Mitsuhashi
  • Organizer: 14^<th> international congress of Hormonal Steroid and Hormones&Cancer
  • Place of Presentation: エジンバラ
  • Year and Date: 2010-09-23
• [Presentation] Metformin directly inhibits cell proliferation in endometrial cancer (2010)
  • Author(s): Akira Mitsuhashi, et al
  • Organizer: 14^<th> international congress of Hormonal Steroid and Hormones & Cancer
  • Place of Presentation: イギリス・エジンバラ
  • Year and Date: 2010-09-22
• [Presentation] 子宮体癌に対するメトホルミンの効果:作用機序の検討と臨床応用 (2010)
  • Author(s): 三橋暁, 他
  • Organizer: 第11回ホルモンと癌研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-07-30
• [Presentation] 子宮内膜癌に対するメトホルミンの抗腫瘍効果とその機序の検討 (2010)
  • Author(s): 三橋暁, 他
  • Organizer: 第48回婦人科腫瘍学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-22
• [Presentation] 子宮内膜癌に対するメトホルミンの抗腫瘍効果とその機序の検討 (2010)
  • Author(s): 三橋暁
  • Organizer: 婦人科腫瘍学会
  • Place of Presentation: 筑波
  • Year and Date: 2010-07-22
• [Presentation] 子宮体癌に対するメトホルミンの効果:臨床応用と作用機序の検討 (2010)
  • Author(s): 三橋暁
  • Organizer: 第10回関東ホルモンと癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-23