Additional value of 16α-[ 18F] fluoro-17β-oestradiol PET for differential diagnosis between uterine sarcoma and leiomyoma in patients with positive or equivocal findings on[ 18F] fluorodeoxyglucose PET
| Project/Area Number |
21592124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUROKAWA Tetsuji 福井大学, 医学部附属病院, 講師 (60334835)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 婦人科腫瘍学 / PET / 糖代謝 / エストロゲン / レセプター / 子宮肉腫 / 子宮筋腫 / FES / FDG |
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| Research Abstract |
Pathologic data suggest that the rate of estrogen receptor(ER) expression in uterine sarcoma is significantly lower than in leiomyoma. The present study aimed to investigate whether ER expression using ER imaging agents for positron emission tomography(PET)(of which the most successful has been 16α-[18F]-fluoro-17β-estradiol(FES))(FES-PET) is able to add useful information to the differential diagnosis of uterine sarcoma and leiomyoma in patients with positive or equivocal findings on[18F] fluorodeoxyglucose(FDG)-PET(FDG-PET). Additional FES-PET findings confirmed uterine sarcoma in 91. 3% of a selected group of patients with equivocal or positive FDG uptake.
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Report
(4 results)
Research Products
(15 results)
