Additional value of 16α-[ 18F] fluoro-17β-oestradiol PET for differential diagnosis between uterine sarcoma and leiomyoma in patients with positive or equivocal findings on[ 18F] fluorodeoxyglucose PET

• Project/Area Number: 21592124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Fukui
• Principal Investigator: YOSHIDA Yoshio 福井大学, 医学部, 准教授 (60220688)
• Co-Investigator(Kenkyū-buntansha): KUROKAWA Tetsuji 福井大学, 医学部附属病院, 講師 (60334835)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 婦人科腫瘍学 / PET / 糖代謝 / エストロゲン / レセプター / 子宮肉腫 / 子宮筋腫 / FES / FDG

Research Abstract

Pathologic data suggest that the rate of estrogen receptor(ER) expression in uterine sarcoma is significantly lower than in leiomyoma. The present study aimed to investigate whether ER expression using ER imaging agents for positron emission tomography(PET)(of which the most successful has been 16α-[18F]-fluoro-17β-estradiol(FES))(FES-PET) is able to add useful information to the differential diagnosis of uterine sarcoma and leiomyoma in patients with positive or equivocal findings on[18F] fluorodeoxyglucose(FDG)-PET(FDG-PET). Additional FES-PET findings confirmed uterine sarcoma in 91. 3% of a selected group of patients with equivocal or positive FDG uptake.

Research Products

• [Journal Article] Additional value of 16α-[^<18> F] fluoro-17β-oestradiol PET for differential diagnosis between uterine sarcoma and leio-myoma in patients with positive or equivocal findings on[^<18> F] fluorodeoxyglucose PET (2011)
  • Author(s): Yoshida Y, Kiyono Y, Tsujikawa T, Kurokawa T, Okazawa H, et al.
  • Journal Title: Eur J Nucl Med Mol Img Volume: 38 Issue: 10 Pages: 1824-31
  • DOI: 10.1007/s00259-011-1851-8
  • Peer Reviewed
• [Journal Article] Functional estrogen receptorαimaging in endometrial carcinoma using 16α-[^<18> F] fluoro-17β-estradiol PET (2011)
  • Author(s): Tsujikawa T, Yoshida Y, Kiyono Y, Kurokawa T, Kudo T, Fujibayashi Y, Kotsuji F, Okazawa H.
  • Journal Title: Eur J Nucl Med Mol Img Volume: 38 Issue: 1 Pages: 37-45
  • DOI: 10.1007/s00259-010-1589-8
  • Peer Reviewed
• [Journal Article] Atypical metastatic carcinoid of the uterine cervix and review of the literatures (2011)
  • Author(s): Y.Yoshida, K.Sato, K.Katayama, A.Yamaguchi, Y.Imamura, F.Kotsuji.
  • Journal Title: The Journal of Obstetrics and Gynecology Research Volume: (in press)
  • Peer Reviewed
• [Journal Article] Advances in imaging techniques fo diagnosis of endometrial cancer Review (2010)
  • Author(s): Yoshida Y, Kurokawa T, Kotsuji F
  • Journal Title: Expert opinion on medical diagnosis Volume: 4 Pages: 281-291
  • Peer Reviewed
• [Journal Article] Localization of p-mTOR expression is critical to tumour progression and outcomes in patients with endometrial cancer. (2010)
  • Author(s): Y.Yoshida, T.Kurokawa, YHoriuchi, Y.Sawamura, A.Shinagawa, F.Kotsuji.
  • Journal Title: Eur J Cancer Volume: 46(18) Pages: 3445-52
  • Peer Reviewed
• [Journal Article] Assessment of fluorodeoxyglucose uptake by leiomyomas in relation to histopathologic subtype and the menstrual state (2009)
  • Author(s): Yoshida Y, Tsujikawa T, Kurokawa T, Tsuji T, Imamura Y, Fujibayashi Y, Okazawa H, Kotsuji F
  • Journal Title: J Comput Assist Tomogr Volume: 33(6) Pages: 877-81
  • Peer Reviewed
• [Journal Article] Assessment of fluorodexyglucose uptake by leiomyomas in relation to histopathologic subtype and the menstrual state. (2009)
  • Author(s): Y.Yoshida, T.Tsujikawa, T.Kurokawa, T.Tsuji, Y.Imamura, Y.Fujibayashi, H.Okaszawa, F.Kotsuji
  • Journal Title: J Comput Assist tomogr 33 Pages: 877-881
  • Peer Reviewed
• [Presentation] The combination of[ 18F] fluorodeoxy-glucose and 16α-[ 18F] fluoro-17β-estradiol positron emission tomography for identifying leiomyosarcoma in uterine smooth muscle tumors (2010)
  • Author(s): Y. Yoshida
  • Organizer: ASCO Annual Meeting
  • Place of Presentation: Chicago(USA)
• [Presentation] The combination of the 18F-deoxy-glucose and 16alpha-18F-fluoro-17beta-estradiol positoron emission tomography is new diagnotic tool in the endometrial cancer (2010)
  • Author(s): Y. Yoshida
  • Organizer: BIT Life Science' 3rd World Cancer Congress 2010
  • Place of Presentation: Singapore
• [Presentation] The combination of [18F]fluorodeoxy-glucose and 16α-[18F]fluoro-17β-estradiol positron emission tomography for identifying leiomyosarcoma in uterine smooth muscle tumors (2010)
  • Author(s): Y.Yoshida
  • Organizer: ASCO Annual Meeting
  • Place of Presentation: Chicago(USA)
• [Presentation] The combination of the 18F-deoxy-glucose and 16alpha-18F-fluoro-17beta-estradiol positoron emission tomography is new diagnotic tool in the endometrial cancer. (2010)
  • Author(s): Y.Yoshida
  • Organizer: BIT Life Science' 3rd World Cancer Congress 2010
  • Place of Presentation: Singapore
• [Presentation] The Combination ob the 18F-Deoxy-Glucose and 16α-18F-17β-Estradiol Positron Emission Tomography is New Diagnostic Tool in the Endometrial Cancer (2009)
  • Author(s): Y. Yoshida
  • Organizer: BIT 2^<nd> Annual Congress and Expo of Molecular Diagnostic(CEMD-2009)
  • Place of Presentation: Beijing(China)
  • Year and Date: 2009-11-21
• [Presentation] The Combination ob the 18F-Deoxy-Glucose and 16α-18F-17β-Estradiol Positron Emission Tomography is New Diagnostic Tool in the Endometrial Cancer (2009)
  • Author(s): Y.Yoshida
  • Organizer: BIT 2^<nd> Annual Congress and Expo of Molecular Diagnostic(CEMD-2009)
  • Place of Presentation: Beijing (China)
  • Year and Date: 2009-11-21
• [Book] 臨床医とコメディカルのための最新クリニカルPET (2011)
  • Author(s): 辻川哲也,吉田好雄,岡沢秀彦
  • Publisher: 先端医療技術研究所出版
• [Book] 「臨床医とコメディカルのための最新クリニカルPET」第7章11.子宮・卵巣癌 (2010)
  • Author(s): 辻川哲也, 吉田好雄, 岡沢秀彦
  • Publisher: 先端医療技術研究所出版