Development of sensitivity test for anti-cancer agents by PET imaging : Try the imaging of P-glycoprotein in cell

• Project/Area Number: 21592125
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: University of Fukui
• Principal Investigator: KUROKAWA Tetsuji 福井大学, 医学部・附属病院, 講師 (60334835)
• Co-Investigator(Kenkyū-buntansha): KIYONO Yasusi 福井大学, 高エネルギー医学研究センター, 教授 (50305603) ; KOTSUJI Fumikazu 福井大学, 医学部, 教授 (50153573) ; YOSHIDA Yoshio 福井大学, 医学部, 准教授 (60220688) ; SHIGAWA Akiko 福井大学, 医学部, 助教 (90444223)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 婦人科腫瘍学 / 抗癌剤 / 感受性試験 / PET / P糖蛋白 / シスプラチン / P糖たんぱく

Research Abstract

Our data indicated the possibility that two proteins(P-glycoprotein and hCtr-1) were target protein of sensitivity test for anti-cancer agents. And we weren' t able to get the success of making the molecular imaging drug for the proteins. We could resolve one of the mechanism for resistance of anti-cancer drugs and release the manuscriptpublication

Research Products

• [Journal Article] Siddik ZH Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner (2010)
  • Author(s): Kurokawa T, He G
  • Journal Title: Cancer Chemotherpy Pharmacology Volume: 65(3) Issue: 3 Pages: 427-36
  • DOI: 10.1007/s00280-009-1045-2
  • Peer Reviewed
• [Journal Article] Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in aschedule-dependent manner. (2010)
  • Author(s): Kurokawa T, He G, Siddik ZH
  • Journal Title: Cancer Chemotherpy Pharmacology Volume: 65 Pages: 427-436
  • Peer Reviewed
• [Journal Article] Protein kinase inhibitors emodin and dichlororibofuranosy l-benzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner (2010)
  • Author(s): Tetsuji. Kurokawa, Guangan He, Zahid H. Siddik
  • Journal Title: Cancer Chemother Pharmacol 65 Pages: 427-436
  • Peer Reviewed
• [Presentation] プラチナ抵抗性卵巣癌の機序の一つであるhCTR-1の機能についての検討 (2011)
  • Author(s): 黒川哲司,吉田好雄,後藤健次,辻隆博,品川明子,澤村陽子,津吉秀昭,小辻文和
  • Organizer: 第50回日本婦人科腫瘍学会
  • Place of Presentation: シンポジスト
  • Year and Date: 2011-07-22
• [Presentation] プラチナ抵抗性卵巣癌の機序の一つであるhCTR-1の機能についての検討 (2011)
  • Author(s): 黒川哲司、吉田好雄、後藤健次、辻隆博、品川明子、澤村陽子、津吉秀昭、小辻文和
  • Organizer: 第50回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: 札幌市