immune environment in the peritoneal cavity and development of novel immune therapy in ovarian cancer
| Project/Area Number |
21592130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
MANDAI Masaki 京都大学, 医学研究科, 講師 (80283597)
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| Co-Investigator(Kenkyū-buntansha) |
KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
MATSUMURA Noriomi 京都大学, 医学研究科, 助教 (20452336)
八木 治彦 京都大学, 医学研究科, 助教 (70402857)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 卵巣癌 / 腹膜播種 / 腫瘍免疫 / PD-L1 / 免疫逃避機構 / 局所免疫 / 包括的解析 / 予後 / 局所免疫環境 / 化学療法 / CD8T細胞 / 腹腔内進展 |
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| Research Abstract |
In this study, we hypothesized that cancer cells actively alter immune environment in the peritoneal cavity I order to disseminate. By using human ovarian cancer samples as well as mouse ovarian cancer peritoneal dissemination model, we thoroughly analyzed the association between immune environment and cancer dissemination. We found that PD-L1, an immune suppressive molecule, is expressed or induced by encountering the immune cells in the peritoneal cavity. Forced expression of PD-L1 resulted in the promotion of peritoneal dissemination, while inhibition of PD-L1 inhibited it. These result indicate that, in ovarian cancers with high PD-L1 expression, this molecule could be a therapeutic target to suppress peritoneal dissemination.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer2012
Author(s)
Yamamura S, Matsumura N, Mandai M, Huang Z, Oura T, Baba T, Hamanishi J, Yamaguchi K, Kang HS, Okamoto T, Abiko K, Mori S, Murphy SK, Konishi I.
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Journal Title
Int J Cancer
Volume: 130(1)
Issue: 1
Pages: 20-8
DOI
Related Report
Peer Reviewed
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