| Project/Area Number |
21592133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kobe University |
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Principal Investigator |
OHARA Noriyuki 神戸大学, 大学院・医学研究科, 医学研究員 (70214210)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Shigeki 神戸大学, 医学研究科, 准教授 (70294212)
NAKABAYASHI Koji 神戸大学, 医学部附属病院, 講師 (80362789)
YAMADA Hideto 神戸大学, 医学研究科, 教授 (40220397)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 子宮筋腫 / SOX4 / SPRM / 増殖 / アポトーシス / 筋腫 / 増殖能 / Progesterone |
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| Research Abstract |
The effect of SPRM on the Sox4 mediated growth of uterine leiomyoma was examined by proliferation and apoptosis assay in cultured leiomyoma cell. These assay included MTT assay, TUNEL assay and protein expression assay of caspase-3, puma, p53, Bcl-2, surviving. We could not observe the significant and constant data in terms of Sox4 related assay in the uterine leiomyoma growth. Further studies are needed to increase the specimen to get final results.
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