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PLKを標的とした婦人科癌の治療とマイクロアレイによる抗癌作用機序の解析

Research Project

Project/Area Number 21592139
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionOita University

Principal Investigator

高井 教行  大分大学, 医学部, 講師 (50295185)

Co-Investigator(Kenkyū-buntansha) 楢原 久司  大分大学, 医学部, 教授 (60211447)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsPLK / 細胞周期 / apoptosis / microarray / 婦人科癌 / Microarray
Research Abstract

われわれがヒト胎盤cDNAライブラリーよりクローニングしたpolo like kinase(PLK)は、細胞分裂時の微小管形成に必須で、いわゆる細胞周期調節蛋白である(Hamanaka et al, 1995)。われわれは、ヒト胎盤(Yoshimatsu et al, 1999)、マウス胎盤(Takai et al,1999)、ヒト正常子宮内膜(Takai et al,2000)、子宮体癌(Takai et al, 2001)、卵巣癌(Takai et al, 2001)でのPLKの発現や機能を報告し、特にPLKの婦人科癌における発現がその病理組織学的予後因子と有意に相関していることを報告した(Takai et al, Oncogene, 2005)。PLKはG2/M期に最も強く発現し、cdc2/cyclin B1のリン酸化を活性化したり、cdc25やcdc27も活性化させる。また細胞分裂の終息に関与するAPC(anaphase-promoting complex)も標的としている(Takai et al, 2008)。
これまでわれわれは、PLKが婦人科癌治療の分子標的となるかどうかを検討するため、PLKの発現を抑制するβ-hydroxyisovalerylshikonin(β-HIVS)と、PLKの発現は変化させずにPLKの機能を阻害するscytoneminの婦人科癌に対する作用についてin vitro,in vivoで検討し、有意な抗癌作用を確認した。そして、これらの薬剤添加後の遺伝子発現変化をマイクロアレイにより解析した。
今年度は、その結果を裏付けるため、northern法、リアルタイムRT-PCR法、western法によるmRNAや蛋白の発現を検討した。その結果、細胞周期・アポトーシス・分化・増殖・転写・シグナル伝達に関連した遺伝子の発現変化を認め、western法でそれらの蛋白発現の変化を確認した。

Report

(4 results)
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (133 results)

All 2012 2011 2010 2009

All Journal Article (46 results) (of which Peer Reviewed: 40 results) Presentation (84 results) Book (3 results)

  • [Journal Article] ベセスダシステムの臨床現場での取り扱い(現状と問題点)2012

    • Author(s)
      高井教行
    • Journal Title

      日本臨床細胞学会大分県支部会誌

      Volume: 22 Pages: 1-7

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Journal Article] Novel chemotherapy using histone deacetylase inhibitors in cervical cancer2011

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 12 Pages: 575-580

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erucylphosphocholine induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cell2011

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Tumour Biol

      Volume: 32 Pages: 569-574

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of bufalin on the proliferation of human choriocarcinoma cells2011

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21 Pages: 1105-1109

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronous ovarian endometrioid adenocarcinoma with a functioning stroma and endometrial endometrioid adenocarcinoma by different loss of heterozygosity findings2011

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Arch Gynecol Obstet

      Volume: 284 Pages: 951-955

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肺癌が原発であった転移性子宮頸癌の1症例2011

    • Author(s)
      高井教行
    • Journal Title

      日本臨床細胞学会大分県支部会誌

      Volume: 21 Pages: 34-36

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮頸がん(HPVワクチン)2011

    • Author(s)
      高井教行
    • Journal Title

      大分県医師会会報

      Volume: 683 Pages: 28-29

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Aberrant DNA methylation status of endometriosis : Epigenetics as the pathogenesis, biomarker and therapeutic targ2011

    • Author(s)
      Kaei Nasu
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37 Issue: 7 Pages: 683-695

    • DOI

      10.1111/j.1447-0756.2011.01663.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of apoptosis-related molecules in endometriosis : a possible mechanism underlying the pathogenesis of endometriosis2011

    • Author(s)
      Kaei Nasu
    • Journal Title

      Reprod Sci

      Volume: 18 Pages: 206-218

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced smal cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery2011

    • Author(s)
      Kaei Nasu
    • Journal Title

      Rare Tumors

      Volume: 3 Pages: 18-20

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of the histone deacetylase inhibitors for the treatment of endometriosis : histone modifications as pathogenesis and novel therapeutic target2011

    • Author(s)
      Yukie Kawano
    • Journal Title

      Hum Reprod.Hum Reprod

      Volume: 26 Pages: 2486-2498

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of positron emission tomography/computed tomography in the management of patients with epithelial ovarian carcinoma after treatment2011

    • Author(s)
      Kaei Nasu
    • Journal Title

      Arch Gynecol Obstet

      Volume: 283 Pages: 1121-1126

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Small cell carcinoma of the endometrium : a report of two cases2011

    • Author(s)
      Harunobu Matsumoto
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37 Issue: 11 Pages: 1739-1743

    • DOI

      10.1111/j.1447-0756.2011.01593.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮頸部に発生した腺様嚢胞癌の2例2011

    • Author(s)
      岩田聡美
    • Journal Title

      日本臨床細胞学会九州連合会会誌

      Volume: 42 Pages: 115-118

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Erucylphosphocholine induces growth inhibition, cell cycle arrest, and apoptosis in human choriocarcinoma cells.2011

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Tumour Biol

      Volume: 32(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Expression of Apoptosis-Related Molecules in Endometriosis : A Possible Mechanism Underlying the Pathogenesis of Endometriosis.2011

    • Author(s)
      Nasu K
    • Journal Title

      Reprod Sci

      Volume: 18(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery.2011

    • Author(s)
      Nasu K
    • Journal Title

      Rare Tumors

      Volume: 3 Pages: 18-20

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone deacetylase inhibitor therapy in epithelial ovarian cancer2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      J Oncol

      Volume: 2010 Pages: 1-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical studies of chemotherapy using histone deacetylase inhibitors in endometrial cancer.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Obstet Gynecol Int

      Volume: 2010 Pages: 1-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic therapy in human choriocarcinoma.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Cancers

      Volume: 2 Pages: 1683-1688

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med

      Volume: 25 Pages: 97-103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synergistic anti-neoplastic effect of AG1478 in combination with cisplatin or paclitaxel on human endometrial and ovarian cancer cells.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Mol Med Rep

      Volume: 3 Pages: 479-484

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-neoplastic effect of β-hydroxyisovalerylshikonin on a human choriocarcinoma cell line.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Mol Med Rep

      Volume: 3 Pages: 515-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of villoglandular papillary adenocarcinoma of the uterine cervix diagnosed during early pregnancy followed by successful term delivery.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Case Reports in Medicine

      Volume: 2010 Pages: 1-3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Villoglandular papillary adenocarcinoma of the uterine cervix diagnosed during pregnancy.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Eur J Gynaecol Oncol

      Volume: 31 Pages: 573-574

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronous ovarian endometrioid adenocarcinoma with a functioning stroma and endometrial endometrioid adenocarcinoma by different loss of heterozygosity findings.2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Arch Gynecol Obstet

      Volume: 2010 Pages: 1-3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer2010

    • Author(s)
      Li H
    • Journal Title

      Cancer Lett

      Volume: 297 Pages: 198-206

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conservative surgical treatment for early-stage vulvar malignant melanoma.2010

    • Author(s)
      Nasu K
    • Journal Title

      Arch Gynecol Obstet

      Volume: 281 Pages: 335-338

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of positron emission tomography/computed tomography in the management of patients with epithelial ovarian carcinoma after treatment2010

    • Author(s)
      Nasu K
    • Journal Title

      Arch Gynecol Obstet

      Volume: 282 Pages: 1-3

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Primary mucinous adenocarcinoma of the vagina.2010

    • Author(s)
      Nasu K
    • Journal Title

      Eur J Gynaecol Oncol

      Volume: 31 Pages: 679-681

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 月経痛2010

    • Author(s)
      高井教行
    • Journal Title

      産婦人科治療

      Volume: 100 Pages: 821-824

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 子宮体癌に対する分子標的治療の現況2010

    • Author(s)
      高井教行
    • Journal Title

      産婦人科治療

      Volume: 101 Pages: 185-192

    • NAID

      40017256259

    • Related Report
      2010 Annual Research Report
  • [Journal Article] クリニカルカンファレンス11子宮体癌トピックス:分子標的治療2010

    • Author(s)
      高井教行
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 62

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 培養子宮内膜症細胞に対するバルプロ酸のエピジェネティック修飾効果についての検討2010

    • Author(s)
      川野由紀枝
    • Journal Title

      本エンドメトリオーシス会誌

      Volume: 31 Pages: 222-224

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Histone deacetylase inhibitor therapy in epithelial ovarian cancer2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      J Oncol 2010

      Pages: 1-6

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical studies of chemotherapy using histone deacetylase inhibitors in endometrial cancer2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Obstet Gynecol Int 2010

      Pages: 1-8

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PK11195 enhances chemosensitivity to cisplatin and paclitaxel in human endometrial and ovarian cancer cells2010

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Int J Mol Med 25

      Pages: 97-103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conservative surgical treatment for early-stage vulvar malignant melanoma2010

    • Author(s)
      Kaei Nasu
    • Journal Title

      Arch Gynecol Obstet 280

      Pages: 335-338

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting calcium/calmodulin-dependence kinase I and II as a potential anti-Proliferation remedy for endometrial carcinomas2009

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Cancer Lett 277

      Pages: 235-243

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoepithelioma-like carcinoma of the uterine cervix2009

    • Author(s)
      Noriyuki Takai
    • Journal Title

      Arch Gynecol Obstet 280

      Pages: 725-727

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current status of primary cytoreductive surgery for the treatment of advanced epithelial ovarian cancer2009

    • Author(s)
      Kaei Nasu
    • Journal Title

      Current Cancer Therapy Reviews 5

      Pages: 67-79

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of primary cytoreductive surgery for the treatment of advanced epithelial ovarian cancer2009

    • Author(s)
      Kaei Nasu
    • Journal Title

      Curr Res in Cancer 3

      Pages: 205-221

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multimodal treatment for glassy cell carcinoma of the uterine cervix2009

    • Author(s)
      Kaei Nasu
    • Journal Title

      J Obstet Gynaecol Res 35

      Pages: 584-587

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of benign metastasizing leiomyoma treated by surgical castration followed by an aromatase inhibitor, anastrozole2009

    • Author(s)
      Kaei Nasu
    • Journal Title

      Arch Gynecol Obstet 279

      Pages: 255-257

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metastatic Uterine Cervical Cancer Originating in the Lung : A Case Report2009

    • Author(s)
      Kentaro Kai
    • Journal Title

      Gynecol Obstet Invest 68

      Pages: 269-271

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A successful pregnancy and delivery after resectoscopic surgery for early invasive endometrial cancer2009

    • Author(s)
      Hideo Matsumoto
    • Journal Title

      Eur J Gynaecol Oncol 30

      Pages: 689-690

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 子宮頸がんの予防、診断と治療2012

    • Author(s)
      高井教行
    • Organizer
      宮崎県北産婦人科医会学術講演会
    • Place of Presentation
      宮崎(招待講演)
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Scytoneminの子宮内膜癌・卵巣癌に対する抗癌作用2012

    • Author(s)
      高井教行
    • Organizer
      第11回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2012-06-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] テルミサルタンの子宮内膜癌に対する抗癌作用機序の解明2012

    • Author(s)
      吉良尚子
    • Organizer
      第11回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      栃木
    • Year and Date
      2012-06-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] 卵巣子宮内膜症性嚢胞のホルモン療法中に診断された明細胞腺癌の1例2012

    • Author(s)
      竹林兼利
    • Organizer
      平成24年度第62回大分産科婦人科学会・第63回大分県産婦人科医会総会・学術講演会
    • Place of Presentation
      大分
    • Year and Date
      2012-06-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] 再発子宮体がんに対する分子標的治療2012

    • Author(s)
      高井教行
    • Organizer
      第9回婦人科がん会議
    • Place of Presentation
      三重(招待講演)
    • Year and Date
      2012-06-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] マイクロサテライトDNA多型マーカーにより鑑別した卵巣類内膜腺癌と子宮体部類内膜腺癌の重複癌2012

    • Author(s)
      矢野光剛
    • Organizer
      第69回九州連合産科婦人科学会・第63回日本産婦人科医会九州ブロック会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-05-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] CaMKI, IIを標的とした子宮内膜癌,卵巣癌の治療2012

    • Author(s)
      高井教行
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cucurbitacin Dの子宮内膜癌細胞株に対する抗腫瘍効果2012

    • Author(s)
      石井照和
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腟原発のNon Hodgkinリンパ腫の一例2012

    • Author(s)
      岡本真実子
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 妊娠高血圧症候群を合併した胎盤におけるeNOSの発現低下について2012

    • Author(s)
      西田正和
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cucurbitacin I の卵巣癌細胞株における抗癌作用の検討2012

    • Author(s)
      吉良尚子
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 進行卵巣癌に対するradical surgery の有用性2012

    • Author(s)
      奈須家栄
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 術後病理診断で発見された卵管adenomatoid tumorの1例2012

    • Author(s)
      井上尚実
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮内膜症におけるDNAメチル化の異常-cDNAマイクロアレイによる検討-2012

    • Author(s)
      川野由紀枝
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-04-13
    • Related Report
      2012 Annual Research Report
  • [Presentation] 悪性線維性組織球腫合併妊娠の1例2012

    • Author(s)
      津末初美
    • Organizer
      第107回大分県周産期研究会
    • Place of Presentation
      大分
    • Year and Date
      2012-03-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 顆粒膜細胞腫の腹水細胞診2012

    • Author(s)
      高井教行
    • Organizer
      第27回日本臨床細胞学会大分県支部総会・学術集会
    • Place of Presentation
      大分
    • Year and Date
      2012-02-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大分婦人科悪性腫瘍研究会統計作業部会報告2012

    • Author(s)
      角沖久夫
    • Organizer
      第21回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分
    • Year and Date
      2012-02-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Narrow Band Imaging (NBI)システムを用いて子宮鏡下腫瘍摘出術を行った子宮体癌の1症例2012

    • Author(s)
      宇津宮由布子
    • Organizer
      第21回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分
    • Year and Date
      2012-02-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮内膜症におけるDNAメチル化の異常-cDNAマイクロアレイによる検討-2012

    • Author(s)
      川野由紀枝
    • Organizer
      第33回日本エンドメトリオーシス学会
    • Place of Presentation
      長崎
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮頸がんの診断と治療~当科の試みも含めて~2011

    • Author(s)
      高井教行
    • Organizer
      日医生涯教育協力講座セミミナー女性のがん「子宮頸がんを巡る最新の話題~最新の治療からワクチンによるがん予防まで~」
    • Place of Presentation
      大分
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 妊娠高血圧症候群を合併した胎盤におけるeNOSの発現低下について2011

    • Author(s)
      西田正和
    • Organizer
      第19回日本胎盤学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 雷公藤(ライコウトウ)の主成分ドリフトライトの婦人科癌に対する抗癌作用2011

    • Author(s)
      高井教行
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] テルミサルタンの子宮内膜癌に対する抗癌作用2011

    • Author(s)
      吉良尚子
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Marine natural productであるscytoneminの卵巣癌に対する抗癌作用2011

    • Author(s)
      石井照和
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 帝王切開瘢痕部妊娠に対するopen surgical treatment2011

    • Author(s)
      甲斐健太郎
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 初期外陰悪性黒色腫に対するconservative surgery についての検討2011

    • Author(s)
      奈須家栄
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣原発の腺扁平上皮癌の1症例2011

    • Author(s)
      西田正和
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 培養子宮内膜症細胞に対するHDAC inhibitor, Suberoylanilide hydroxamic acid (SAHA)のエピジェネティック修飾による治療効果の検討2011

    • Author(s)
      川野由紀枝
    • Organizer
      第63回日本産科婦人科学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] カルシウム・カルモジュリン依存性キナーゼ阻害は子宮体癌細胞の増殖を抑制する2011

    • Author(s)
      高井教行
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌細胞株に対するscytoneminの抗癌作用2011

    • Author(s)
      石井照和
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] テルミサルタンの子宮内膜癌に対する抗癌作用2011

    • Author(s)
      吉良尚子
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] CA125の上昇を認めた卵巣硬化性間質性腫瘍の1症例2011

    • Author(s)
      河野康志
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腟原発粘液性腺癌の1例2011

    • Author(s)
      甲斐健太郎
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腟原発のNon-Hodgkinリンパ腫の一例2011

    • Author(s)
      西田正和
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 初期外陰悪性黒色腫に対する手術療法についての検討2011

    • Author(s)
      奈須家栄
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      北海道
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮内膜癌に対するK-252aの抗癌作用2011

    • Author(s)
      高井教行
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      島根
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] テルミサルタンの子宮内膜癌に対する抗癌作用2011

    • Author(s)
      吉良尚子
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      島根
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 帝王切開瘢痕部妊娠の管理2011

    • Author(s)
      甲斐健太郎
    • Organizer
      第68回九州連合産科婦人科学会、第62回日本産婦人科医会九州ブロック会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-06-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌の治療2011

    • Author(s)
      高井教行
    • Organizer
      オンコロジー研修会
    • Place of Presentation
      大分
    • Year and Date
      2011-06-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] CaMKI,IIの子宮内膜癌における発現と治療への応用2011

    • Author(s)
      高井教行
    • Organizer
      第52回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      福岡
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Discovery of epigenetically unmarked novel tumor suppressor genes in endometrial carcinoma using high-throughput microarray2011

    • Author(s)
      Kentaro Kai
    • Organizer
      The American College of Obstetricians and Gynecologist 59th Annual Clinical Meeting
    • Place of Presentation
      Washington D.C., USA
    • Year and Date
      2011-04-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大分婦人科悪性腫瘍研究会統計作業部会報告2011

    • Author(s)
      中村聡
    • Organizer
      第20回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分県
    • Year and Date
      2011-03-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膣原発粘液性腺癌の1例2011

    • Author(s)
      甲斐健太郎
    • Organizer
      第20回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分県
    • Year and Date
      2011-03-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] ベセスダシステムの臨床現揚での取り扱い(現状と問題点)2011

    • Author(s)
      高井教行
    • Organizer
      第26回日本臨床細胞学会大分県支部総会・学術集会
    • Place of Presentation
      大分県
    • Year and Date
      2011-02-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣癌治療後の管理におけるPET/CTの有用性2010

    • Author(s)
      奈須家栄
    • Organizer
      第48回日本癌治療学会学術集会
    • Place of Presentation
      京都府
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synchronous ovarian endometrioid adenocarcinoma with a functioning stroma and endometrial endometrioid adenocarcinoma demonstrated different microsatellite instability findings.2010

    • Author(s)
      Noriyuki Takai
    • Organizer
      The 13th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2010)
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2010-10-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Current status of and perspectives on therapy for cervical cancer in Japan.2010

    • Author(s)
      Noriyuki Takai
    • Organizer
      The Joint Meeting of JGOG and the University of Rome
    • Place of Presentation
      Rome, Italy
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Polo like kinase (PLK)の発現を抑制するβ-hydroxyisovalerylshikoninの絨毛癌に対する抗癌作用2010

    • Author(s)
      高井教行
    • Organizer
      第28回日本絨毛性疾患研究会
    • Place of Presentation
      熊本県
    • Year and Date
      2010-09-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] エピジェネティクスにより発現の抑制された子宮体癌の新しい癌抑制遺伝子の発見とその遺伝子導入による治療戦略2010

    • Author(s)
      高井教行
    • Organizer
      中九州三大学病院合同専門医養成プログラム:産科婦人科合同カンファレンスin人吉
    • Place of Presentation
      熊本県
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮内膜癌におけるcalcium/calmodulin-dependent kinase I, IIの発現とそれらを標的とするKN-93の抗癌作用2010

    • Author(s)
      高井教行
    • Organizer
      第9回日本婦人科がん分子標的研究会
    • Place of Presentation
      滋賀県
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮頸部に発生した腺様嚢胞癌の2例2010

    • Author(s)
      岩田聡美
    • Organizer
      第26回日本臨床細胞学会九州連合会学会
    • Place of Presentation
      長崎県
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 婦人科癌に対するトリプトライドの抗癌作用とその標的遺伝子の検索2010

    • Author(s)
      高井教行
    • Organizer
      第48回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      茨城県
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上皮性卵巣癌の再発診断におけるPET/CTの有用性2010

    • Author(s)
      奈須家栄
    • Organizer
      第48回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      茨城県
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 巣原発の腺扁平上皮癌の1例2010

    • Author(s)
      西田正和
    • Organizer
      第48回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      茨城県
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体部に発生した小細胞癌の二例2010

    • Author(s)
      松本治伸
    • Organizer
      第48回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      茨城県
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌性髄膜炎を発症した卵巣小細胞癌の一例2010

    • Author(s)
      吉良尚子
    • Organizer
      第48回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      茨城県
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肉眼的に水腫様変化が認められなかったにもかかわらず遺伝子解析により全奇胎と診断された1症例2010

    • Author(s)
      川野由紀枝
    • Organizer
      第60回日本産科婦人科学会大分地方部会、第61回大分県産婦人科医会総会
    • Place of Presentation
      大分県
    • Year and Date
      2010-07-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣奇形腫関連傍腫瘍性脳炎が疑われた腹腔鏡下に卵巣摘出術を施行した2症例2010

    • Author(s)
      楠本真実子
    • Organizer
      第22回大分内視鏡外科研究会
    • Place of Presentation
      大分県
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮内膜原発と考えられる小細胞癌の2症例2010

    • Author(s)
      高井教行
    • Organizer
      第51回日本臨床細胞学会総会(春期大会)
    • Place of Presentation
      神奈川県
    • Year and Date
      2010-05-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣奇形腫関連傍腫瘍性脳炎が疑われた2症例2010

    • Author(s)
      楠本真実子
    • Organizer
      第67回九州連合産科婦人科学会、第61回日本産婦人科医会九州ブロック会
    • Place of Presentation
      福岡県
    • Year and Date
      2010-05-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自然界の水中産物scytoneminの子宮内膜癌に対する抗癌作用2010

    • Author(s)
      高井教行
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 初回治療後の上皮性卵巣癌のfollow upにおけるPET/CTの有用性についての検討2010

    • Author(s)
      阿部若菜
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 塩酸イリノテカン+シスプラチンが著効し、その後の再発に対して塩酸アムルビシンを投与した子宮頸部小細胞癌の1症例2010

    • Author(s)
      平川東望子
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 円錐切除後の頸管狭窄に対する保存的治療2010

    • Author(s)
      奈須家栄
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] クリニカルカンファレンス11.「子宮体癌トピックス」分子標的治療2010

    • Author(s)
      高井教行
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京都
    • Year and Date
      2010-04-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epigenetically silenced tumor suppressor genes and histone deacetylase in hibitor therapy in gynecologic cancers.2010

    • Author(s)
      Noriyuki Takai
    • Organizer
      The 11th Symposium German-Japanese Society of Obstetrics and Gynecology-Satellite Symposium in Kumamoto
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2010-04-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 婦人科癌におけるエピジェネティクスを介した新しい治療法の開発と新しい癌抑制遺伝子の発見2010

    • Author(s)
      高井教行
    • Organizer
      第21回医大ヶ丘研究会
    • Place of Presentation
      大分県
    • Year and Date
      2010-03-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺癌からの子宮頸部転移の細胞診像2010

    • Author(s)
      高井教行
    • Organizer
      第25回日本臨床細胞学会大分県支部総会および学術集会
    • Place of Presentation
      大分県
    • Year and Date
      2010-02-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大分婦人科悪性腫瘍研究会統計作業部会報告2010

    • Author(s)
      松本英雄
    • Organizer
      第19回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分県
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 癌性髄膜炎を呈した卵巣小細胞癌の一例2010

    • Author(s)
      吉良尚子
    • Organizer
      第19回大分婦人科悪性腫瘍研究会
    • Place of Presentation
      大分県
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 婦人科癌とエピジェネティクス(新しい治療法の開発と新しい癌抑制遺伝子の発見を目指して)2009

    • Author(s)
      高井教行
    • Organizer
      第47回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2009-11-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 初回治療後の上皮性卵巣癌の管理におけるPET/CTの有用性についての検討2009

    • Author(s)
      奈須家栄
    • Organizer
      JSAWI(The Japanese Society for the Advancement of Women's Imaging)2009第10回シンポジウム
    • Place of Presentation
      兵庫県
    • Year and Date
      2009-09-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] 女性生殖器がんの病態と診断、治療2009

    • Author(s)
      高井教行
    • Organizer
      平成21年度大分県がん看護実務研修会
    • Place of Presentation
      大分県
    • Year and Date
      2009-08-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] Marine natural product である scytonemin の子宮内膜癌に対する抗癌作用2009

    • Author(s)
      高井教行
    • Organizer
      第46回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      新潟県
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 円錐切除術後の頚管狭窄に対するIUDとナイロン糸を用いた保存的治療法2009

    • Author(s)
      奈須家栄
    • Organizer
      第46回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      新潟県
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 膣悪性黒色腫の1症例2009

    • Author(s)
      西田正和
    • Organizer
      第46回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      新潟県
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 良性多胞性腹膜中皮腫の1症例2009

    • Author(s)
      古川雄一
    • Organizer
      第46回日本婦人科腫瘍学会学術集会
    • Place of Presentation
      新潟県
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肺原発転移性子宮頸癌の1症例2009

    • Author(s)
      高井教行
    • Organizer
      第50回日本臨床細胞学会(春季大会)
    • Place of Presentation
      東京都
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] Epigenetically silenced tumor suppressor genes and histone deacetylase inhibitor therapy in gynecologic cancers2009

    • Author(s)
      Noriyuki Takai
    • Organizer
      18th Lake Shirakaba Conference
    • Place of Presentation
      Vedbaek, DENMARK
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] テストステロンが高値であった卵巣類内膜腺癌と子宮体癌の重複癌の1症例2009

    • Author(s)
      楠本真実子
    • Organizer
      第59回日本産科婦人科学会大分地方部会総会
    • Place of Presentation
      大分県
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 左鼠径部の腫脹と疼痛を繰り返した異所性子宮内膜症の1症例2009

    • Author(s)
      吉良尚子
    • Organizer
      第59回日本産科婦人科学会大分地方部会総会
    • Place of Presentation
      大分県
    • Year and Date
      2009-06-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 化学療法が著効した子宮頸部小細胞癌の1症例2009

    • Author(s)
      平川東望子
    • Organizer
      第66回日本産科婦人科学会九州連合地方部会
    • Place of Presentation
      宮崎県
    • Year and Date
      2009-05-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 子宮頸部 lymphoepithelioma-like carcinoma の3例2009

    • Author(s)
      吉良尚子
    • Organizer
      第66回日本産科婦人科学会九州連合地方部会
    • Place of Presentation
      宮崎県
    • Year and Date
      2009-05-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bipolar vessel sealing system を用いた広汎子宮全摘出術についての検討2009

    • Author(s)
      奈須家栄
    • Organizer
      第61回日本産科婦人科学会総会・学術集会
    • Place of Presentation
      京都府
    • Year and Date
      2009-04-03
    • Related Report
      2009 Annual Research Report
  • [Book] Handbook of Cell Proliferation Editors : Andre P. Briggs and Jacob A. Coburn2009

    • Author(s)
      Noriyuki Takai
    • Total Pages
      437
    • Publisher
      Polo-like kinases(Plks)and cell proliferation in gynecologic cancers
    • Related Report
      2009 Annual Research Report
  • [Book] 今日の治療指針―私はこうして治療している―2009山口徹、北原光夫、福井次矢 総編集2009

    • Author(s)
      高井教行
    • Total Pages
      1753
    • Publisher
      受胎調節(避妊法) contraception
    • Related Report
      2009 Annual Research Report
  • [Book] 産婦人科研修ノート 三橋直樹、綾部琢哉 編集2009

    • Author(s)
      高井教行
    • Total Pages
      538
    • Publisher
      帯下
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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