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Non-weight-bearing effect of trunk and peripheral fat mass on bone mineral density in pre-and post-menopausal women

Research Project

Project/Area Number 21592140
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKagoshima University

Principal Investigator

DOUCHI Tsutomu  鹿児島大学, 大学院・医歯学総合研究科, 教授 (60150413)

Co-Investigator(Kenkyū-buntansha) IWAMOTO Ichiro  鹿児島大学, 医学部・歯学部附属病院, 助教 (50281225)
TSUJI Takahiro  鹿児島大学, 大学院・医歯学総合研究科, 助教 (50311882)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords骨塩量 / 内臓脂肪 / 皮下脂肪 / 液性因子 / エストロゲン / 非荷重効果
Research Abstract

Objective : To investigate the non-weight-bearing effect of trunk fat mass(composed ofvisceral and subcutaneous fat mass) and peripheral fat mass(subcutaneous fat mass alone) on bone mineral density(BMD) in pre-and post-menopausal women.
Methods : The subjects were 412 pre-menopausal women, 20. 50 years of age and 228post-menopausal women, 50. 75 years of age. Age, years since menopause(YSM), height, body weight, and body mass index were recorded. Trunk, peripheral(extremities), left arm(non-weight-bearing site), lean mass, and BMD were measured by dual-energy X-ray absorptiometry.
Results : In pre-menopausal women, the amount of trunk fat mass was 6.8±4.1 kg, which was significantly lower than the amount of peripheral fat mass(11.6±3.8 kg, p<0.001). Although trunk fat mass was positively correlated with arm BMD on Pearson's correlation test, arm lean mass was the only significant predictor of BMD onmultiple regression analysis. In post-menopausal women, the amount of trunk fat mass(8.7±3.6 kg) was also significantly lower than the peripheral fat mass(10.3±3.4kg, p<0.001). On multiple regression analysis, however, trunk fat mass, but not arm lean mass, was the significant predictor of BMD. In both groups, peripheral fat mass was not correlated with left arm BMD.
Conclusion : The effect of adipocyte-derived biochemical factors on BMD may differ with menopausal status and the sites of adipocyte deposition.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009

All Journal Article (19 results) (of which Peer Reviewed: 10 results) Presentation (10 results)

  • [Journal Article] Large parasitic myomas in abdominal subcutaneous adipose tissue along a previous myomectomy scar2012

    • Author(s)
      Yanazume S, Tsuji T, Yoshioka T, Yamasaki H, Yoshinaga M, Douchi T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 38 Issue: 5 Pages: 875-879

    • DOI

      10.1111/j.1447-0756.2011.01784.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relative contribution of weight-bearing and non-weight-bearing effect of adipose tissue to bone mineral density in postmenopausal women2011

    • Author(s)
      Kawamura Y, Yanazume Y, Kuwahata A, Yonehara Y, Iwamoto I, Tsuji T, Douchi T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 37(4) Issue: 4 Pages: 319-24

    • DOI

      10.1111/j.1447-0756.2010.01352.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 第25回日本更年期医学会学術集会(2010)の話題2011

    • Author(s)
      堂地勉
    • Journal Title

      FUJI Infertility Menopause News

      Volume: 12 Pages: 10-11

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 女性のヘルスケアをめぐる最近の話題2011

    • Author(s)
      堂地勉、岩元一朗
    • Journal Title

      産婦人科治療

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 肥満と月経異常2011

    • Author(s)
      堂地勉
    • Journal Title

      臨床婦人科産科

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
  • [Journal Article] HRT2011

    • Author(s)
      岩元一朗、堂地勉
    • Journal Title

      産婦人科学レビュー

      Volume: (In press)

    • NAID

      110009509175

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 私のHRT処方2011

    • Author(s)
      岩元一朗、堂地勉
    • Journal Title

      更年期と加齢のヘルスケア

      Volume: 9 Pages: 300-301

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 更年期における骨量減少症・骨粗鬆症の検査2011

    • Author(s)
      岩元一朗、堂地勉
    • Journal Title

      臨床検査

      Volume: 55 Pages: 247-254

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Difference in non-weight-bearing effects on bone mineral density between trunk and peripheral fat mass in women with polycystic ovary syndrome2010

    • Author(s)
      Yanazume Y, Kawamura Y, Kuwahata A, Yonehara Y, Matsuo T, Iwamoto I, Douchi T.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 36(2) Pages: 352-6

    • NAID

      10031121620

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症診療における産婦人科医の役割-閉経後乳がん治療薬(アロマターゼ阻害薬)の有害事象に関する検討)2010

    • Author(s)
      古謝将一郎、岩元一朗、堂地勉, 他
    • Journal Title

      Osteoporosis Japan

      Volume: 18(3) Pages: 534-536

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 体脂肪組織の骨塩量(BMD)に及ぼす影響-非荷重効果と荷重効果の影響の強さの差異に関する検討-2010

    • Author(s)
      河村幸枝、福田美香、堂地勉, 他
    • Journal Title

      Osteoporosis Japan

      Volume: 18(3) Pages: 466-468

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 肥満症up date2010

    • Author(s)
      堂地勉
    • Journal Title

      肥満に伴う諸問題-病態と治療「肥満と婦人科疾患」綜合臨床

      Volume: 59(9) Pages: 1956-1963

    • Related Report
      2011 Final Research Report
  • [Journal Article] PCOSとインスリン抵抗性の関連性(Insulin Resistance in Polycystic Ovary Syndrome)現状と今後の展開2010

    • Author(s)
      堂地勉
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 62 Pages: 1017-1024

    • NAID

      110007593854

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Difference in non-weight-bearing effects on bone mineral density between trunk and peripheral fat mass in women with polycystic ovary syndrome.2010

    • Author(s)
      Yanazume S, Douchi T, et al
    • Journal Title

      Histopathology

      Volume: 36 Pages: 352-356

    • NAID

      10031121620

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse events and bone health during anastrozole therapy in postmenopausal Japanese breast cancer patients.2010

    • Author(s)
      Sagara Y, Douchi T, et al
    • Journal Title

      Breast Cancer

      Volume: 17 Pages: 212-217

    • NAID

      10027255815

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adverse events and bone health during anastrozole therapy in postmenopausal Japanese breast cancer patients2009

    • Author(s)
      Sagara Y, Kosha S, Baba S, Dokiya F, Tamada S, Sagara Y, Matsuyama Y, Ohi Y, Ando M, Rai Y, Sagara Y, Douchi T.
    • Journal Title

      Breast Cancer

      Volume: 17(3) Pages: 212-7

    • NAID

      10027255815

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] メタボリックシンドローム2009

    • Author(s)
      岩元一朗、堂地勉
    • Journal Title

      臨床婦人科産科

      Volume: 63 Pages: 836-843

    • Related Report
      2011 Final Research Report
  • [Journal Article] 閉経と脂質異常症2009

    • Author(s)
      堂地勉
    • Journal Title

      日本産科婦人科学会鹿児島地方部会雑誌

      Volume: 17 Pages: 1-7

    • Related Report
      2011 Final Research Report
  • [Journal Article] Adverse events and bone health during anastrozole therapy in postmen opausal Japanese breast cancer patients2009

    • Author(s)
      Sagara Y
    • Journal Title

      Breast Cancer 13 June 2009(Published online)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 体脂肪分布・体組織成分と骨塩量の関連性2010

    • Author(s)
      堂地勉
    • Organizer
      第25回日本更年期医学会学術集会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2010-10-02
    • Related Report
      2011 Final Research Report
  • [Presentation] 会長講演「体脂肪分布・体組織成分と骨塩量の関連性」2010

    • Author(s)
      堂地勉
    • Organizer
      第25回日本更年期医学会学術集会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2010-10-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 閉経後乳がん治療薬(アロマターゼ阻害薬)の有害事象に関する検討2010

    • Author(s)
      古謝将一郎、岩元一朗、堂地勉, 他
    • Organizer
      第123回鹿児島産科婦人科学会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2010-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 体脂肪組織の骨塩量(BMD)に及ぼす影響~非荷重効果と荷重効果の影響の強さの差異に関する検討~2010

    • Author(s)
      河村幸枝、堂地勉
    • Organizer
      第62回日本産科婦人科学会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体脂肪組織の骨塩量(BMD)に及ぼす影響~非荷重効果と荷重効果の影響の強さの差異に関する検討~2009

    • Author(s)
      河村幸枝、福田美香、堂地勉
    • Organizer
      第20回婦人科骨粗鬆症研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 体脂肪組織の骨塩量(BMD)に及ぼす影響~非荷重効果と荷重効果の影響の強さの差異に関する検討~2009

    • Author(s)
      河村幸枝、岩元一朗、堂地勉, 他
    • Organizer
      第24回日本更年期医学会学術集会
    • Place of Presentation
      青森市
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 躯幹の筋肉量は他の部位の筋肉量よりも閉経の影響を受けやすい2009

    • Author(s)
      福田美香、岩元一朗、堂地勉, 他
    • Organizer
      第24回日本更年期医学会学術集会
    • Place of Presentation
      青森市
    • Year and Date
      2009-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 中高年医学最新の話題2009

    • Author(s)
      堂地勉
    • Organizer
      川薩地区産婦人科医会
    • Place of Presentation
      薩摩川内市
    • Year and Date
      2009-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 躯幹脂肪量と末梢脂肪組織の骨塩量(BMD)に及ぼす非荷重効果の相違に関する検討2009

    • Author(s)
      桑波田暁子、岩元一朗、堂地勉
    • Organizer
      第61回日本産科婦人科学会学術集会
    • Place of Presentation
      京都市
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 躯幹脂肪量と末梢脂肪組織の骨塩量(BMD)に及ぼす非荷重効果の相違に関する検討2009

    • Author(s)
      桑波田暁子
    • Organizer
      第61回日本産科婦人科学会学術集会
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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