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Bistandar effect via gap junctional intercellular communication for gene-therapy in gynecologic cancers.

Research Project

Project/Area Number 21592141
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionSapporo Medical University

Principal Investigator

SAITO Tsuyoshi  札幌医科大学, 医学部, 教授 (90145566)

Co-Investigator(Kenkyū-buntansha) SUZUKI Takahiro  札幌医科大学, 医学部, 講師 (60398328)
IWASAKI Masahiro  札幌医科大学, 医学部, 講師 (20516504)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords子宮体癌 / 遺伝子治療 / バイスタンダー効果 / ギャップ結合 / ヘルペスウイルス / 子宮内膜 / コネキシン / パイスタンダー効果
Research Abstract

We have confirmed bistandar effect via gap junctional intercellular communication in gynecologic cancers especially endometrial cancer cell. We have also found the bistandar effect was accelerated to add retinoids.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2012 2011 2010 2009

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (4 results)

  • [Journal Article] High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway2012

    • Author(s)
      Kosuke Yoshihara
    • Journal Title

      Clinical Cancer Research

      Volume: 18 Issue: 5 Pages: 1374-1385

    • DOI

      10.1158/1078-0432.ccr-11-2725

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of cervical conization as a definitive treatment for microinvasive cervical carcinoma and cervical intraepithelial neoplasia grade 32012

    • Author(s)
      Takeda N, Suzuki T, Suzuki M, Matsuura M, Tanaka R, Fujii M, Ito E, Saito T
    • Journal Title

      Arch Gynecol Obstet

      Volume: 285(2) Issue: 2 Pages: 453-7

    • DOI

      10.1007/s00404-011-1944-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses2012

    • Author(s)
      Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N
    • Journal Title

      Exp Mol Pathol.

      Volume: 92 Issue: 1 Pages: 185-190

    • DOI

      10.1016/j.yexmp.2011.10.002

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A remarkably easy knot-tying technique for single-incision laparoscopic surgery with the SILS port for gynecologic diseases2011

    • Author(s)
      Endo T, Nagasawa K, Umemura K, Baba T, Henmi H, Saito T
    • Journal Title

      J Minim Invasive Gynecol

      Volume: 18(4) Issue: 4 Pages: 500-2

    • DOI

      10.1016/j.jmig.2011.03.014

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distinctive Features of Female-to-Male Transsexualism and Prevalence of Gender Identity Disorder in Japan2011

    • Author(s)
      Baba T, Endo T, Ikeda K, Shimizu A, Honnma H, Ikeda H, Masumori N, Ohmura T, Kiya T, Fujimoto T, Koizumi M, Saito T
    • Journal Title

      J Sex Med

      Volume: 8(6) Issue: 6 Pages: 1686-93

    • DOI

      10.1111/j.1743-6109.2011.02252.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] BAG3(BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells2011

    • Author(s)
      Suzuki M, Iwasaki M, Sugio A, Hishiya A, Tanaka R, Endo T, Takayama S, Saito T
    • Journal Title

      Cancer Lett

      Volume: 303(1) Issue: 1 Pages: 65-71

    • DOI

      10.1016/j.canlet.2011.01.019

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] p53 negatively regulates the hepatoma growth factor HDGF2011

    • Author(s)
      Sasaki Y, Negishi H, Idogawa M, Yokota I, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 22 Pages: 7038-47

    • DOI

      10.1158/0008-5472.can-11-1053

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma2011

    • Author(s)
      Matsuura M, Suzuki T, Suzuki M, Tanaka R, Ito E, Saito T
    • Journal Title

      OncolRep

      Volume: 25(1) Issue: 1 Pages: 41-7

    • DOI

      10.3892/or_00001039

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma.2011

    • Author(s)
      Suzuki T, Saito T
    • Journal Title

      Oncol Rep

      Volume: 25 Pages: 41-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells.2011

    • Author(s)
      Iwasaki M, Saito T
    • Journal Title

      Cancer Lett

      Volume: 303 Pages: 65-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful uterus-preserving surgery for treatment of chemotherapy-resistant placenta increta2010

    • Author(s)
      Endo T, Hayashi T, Shimizu A, Matsuura M, Mizuuchi M, Nagasawa K, Ezaka Y, Baba T, Ishioka S, Saito T
    • Journal Title

      Gynecol Obstet Invest

      Volume: 69(2) Issue: 2 Pages: 112-5

    • DOI

      10.1159/000262320

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy2010

    • Author(s)
      Matsuura M, Suzuki T, Saito T
    • Journal Title

      Cancer Sci

      Volume: 101(8) Issue: 8 Pages: 1828-33

    • DOI

      10.1111/j.1349-7006.2010.01615.x

    • NAID

      10027830539

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prediction of histologic type and lymph node metastasis for advanced ovarian cancer on uterine cervical and endometrial cytology2010

    • Author(s)
      Suzuki M, Suzuki T, Matsuura M, Iwasaki M, Tanaka R, Ito E, Fujii M, Saito T
    • Journal Title

      Acta Cytol

      Volume: 54(4) Issue: 4 Pages: 575-81

    • DOI

      10.1159/000325180

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty(fa/fa) rats2010

    • Author(s)
      Honnma H, Endo T, Kiya T, Shimizu A, Nagasawa K, Baba T, Fujimoto T, Henmi H, Kitajima Y, Manase K, Ishioka S, Ito E, Saito T
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 8 Issue: 1 Pages: 73-73

    • DOI

      10.1186/1477-7827-8-73

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes of uterine blood flow after vaginal radical trachelectomy(VRT) in patients with early-stage uterine invasive cervical cancer2010

    • Author(s)
      Umemura K, Ishioka S, Endo T, Baba T, Ezaka Y, Nagasawa K, Takahashi M, Mizuuchi M, Iwami N, Adachi H, Takeda N, Tamagawa M, Saito T
    • Journal Title

      Int J Med Sci

      Volume: 7 Pages: 260-6

    • DOI

      10.7150/ijms.7.260

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy.2010

    • Author(s)
      Suzuki T, Saito T
    • Journal Title

      Cancer Sci

      Volume: 101 Pages: 1828-33

    • NAID

      10027830539

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case-control study of endometrial cancer especially with reference to lifestyle and other factors of Japanese women2009

    • Author(s)
      Asakura S, Mori M, Suzuki T, Saito T
    • Journal Title

      Sapporo Medical Journal

      Volume: 78 Pages: 1-6

    • NAID

      120005941846

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The contributions ofresistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population2009

    • Author(s)
      Baba T, Endo T, Sata F, Nagasawa K, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Moriwaka O, Kamiya H, Yamada H, Minakami H, Kishi R, Saito T
    • Journal Title

      Gynecol Endocrinol

      Volume: 25(8) Issue: 8 Pages: 498-503

    • DOI

      10.1080/09513590902972042

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of planned delivery delay in pregnant patients with invasive gynecologic cancer2009

    • Author(s)
      Ishioka S, Ezaka Y, Endo T, Nagasawa K, Shimizu A, Sato A, Inoue M, Saito T
    • Journal Title

      Int J Clin Oncol

      Volume: 14(4) Issue: 4 Pages: 321-5

    • DOI

      10.1007/s10147-008-0861-4

    • NAID

      10025864101

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma : incidental pregnancy triggers a catastrophic event2009

    • Author(s)
      Baba T, Endo T, Kitajima Y, Kamiya H, Moriwaka O, Saito T
    • Journal Title

      Fertil Steril

      Volume: 92(1) Issue: 1 Pages: 1-3

    • DOI

      10.1016/j.fertnstert.2009.02.071

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemotherapy(CT) with radiotherapy versus CT alone for FIGO Stage IIIc endometrial cancer2009

    • Author(s)
      Matsuura M, Suzuki T, Morishita M, Tanaka R, Ito E, Saito T
    • Journal Title

      Eur J Gynaecol Oncol

      Volume: 30 Pages: 40-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemotherapy(CT)with radiotherapy versus CT alone for FIGO Stage IIIc endometrial cancer2009

    • Author(s)
      Saito T
    • Journal Title

      Eur J Gynaecol Oncol. 30

      Pages: 40-44

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma : incidental pregnancy triggers a catastrophic event2009

    • Author(s)
      Saito T
    • Journal Title

      Fertil Steril 25

      Pages: 498-503

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Osteopontin as a potential molecular target for ovarian clear cell carcinoma therapy2011

    • Author(s)
      Saito T, Iwasaki M
    • Organizer
      ASCO Annual Meeting
    • Place of Presentation
      Chicago, Ilinois
    • Related Report
      2011 Annual Research Report
  • [Presentation] オステオポンチンによる卵巣明細胞癌治療の可能性2010

    • Author(s)
      鈴木孝浩・松浦基樹・鈴木美和・田中綾一・伊東英樹・藤井美穂・斉藤豪
    • Organizer
      第48回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      つくば
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 癌細胞におけるBAG3発現の意義2009

    • Author(s)
      斎藤豪
    • Organizer
      第41回日本臨床分子形態学会
    • Place of Presentation
      神戸市
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 卵巣癌におけるBAG3遺伝子発現2009

    • Author(s)
      鈴木美和・岩崎雅宏・松浦基樹・池田桂子・梅村康太・田中綾一・鈴木孝浩・伊東英樹・斉藤豪
    • Organizer
      第48回日本臨床細胞学会学術総会(日本臨床細胞学会)
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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