Bistandar effect via gap junctional intercellular communication for gene-therapy in gynecologic cancers.

• Project/Area Number: 21592141
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Sapporo Medical University
• Principal Investigator: SAITO Tsuyoshi 札幌医科大学, 医学部, 教授 (90145566)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Takahiro 札幌医科大学, 医学部, 講師 (60398328) ; IWASAKI Masahiro 札幌医科大学, 医学部, 講師 (20516504)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 子宮体癌 / 遺伝子治療 / バイスタンダー効果 / ギャップ結合 / ヘルペスウイルス / 子宮内膜 / コネキシン / パイスタンダー効果

Research Abstract

We have confirmed bistandar effect via gap junctional intercellular communication in gynecologic cancers especially endometrial cancer cell. We have also found the bistandar effect was accelerated to add retinoids.

Research Products

• [Journal Article] High-risk ovarian cancer based on 126-gene expression signature is uniquely characterized by downregulation of antigen presentation pathway. (2012)
  • Author(s): K.Yoshihara, K Tanaka, 他28名
  • Journal Title: Clinical Cancer Research Volume: 18 Pages: 1374-1385
  • DOI: 10.1158/1078-0432.ccr-11-2725
  • Peer Reviewed
• [Journal Article] Evaluation of cervical conization as a definitive treatment for microinvasive cervical carcinoma and cervical intraepithelial neoplasia grade 3 (2012)
  • Author(s): Takeda N, Suzuki T, Suzuki M, Matsuura M, Tanaka R, Fujii M, Ito E, Saito T
  • Journal Title: Arch Gynecol Obstet Volume: 285(2) Pages: 453-7
  • DOI: 10.1007/s00404-011-1944-4
  • Peer Reviewed
• [Journal Article] Novel oligomannose liposome-DNA complex DNA vaccination efficiently evokes anti-HPV E6 and E7 CTL responses (2012)
  • Author(s): Mizuuchi M, Hirohashi Y, Torigoe T, Takafumi K, Yasuda K, Saito T, Sato N
  • Journal Title: Exp Mol Pathol Volume: 92 Pages: 185-190
  • DOI: 10.1016/j.yexmp.2011.10.002
  • Peer Reviewed
• [Journal Article] A remarkably easy knot-tying technique for single-incision laparoscopic surgery with the SILS port for gynecologic diseases (2011)
  • Author(s): Endo T, Nagasawa K, Umemura K, Baba T, Henmi H, Saito T
  • Journal Title: J Minim Invasive Gynecol Volume: 18(4) Pages: 500-2
  • DOI: 10.1016/j.jmig.2011.03.014
  • Peer Reviewed
• [Journal Article] Distinctive Features of Female-to-Male Transsexualism and Prevalence of Gender Identity Disorder in Japan (2011)
  • Author(s): Baba T, Endo T, Ikeda K, Shimizu A, Honnma H, Ikeda H, Masumori N, Ohmura T, Kiya T, Fujimoto T, Koizumi M, Saito T
  • Journal Title: J Sex Med Volume: 8(6) Pages: 1686-93
  • DOI: 10.1111/j.1743-6109.2011.02252.x
  • Peer Reviewed
• [Journal Article] BAG3(BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells (2011)
  • Author(s): Suzuki M, Iwasaki M, Sugio A, Hishiya A, Tanaka R, Endo T, Takayama S, Saito T
  • Journal Title: Cancer Lett Volume: 303(1) Pages: 65-71
  • DOI: 10.1016/j.canlet.2011.01.019
  • Peer Reviewed
• [Journal Article] Negative regulation of hepatoma-derived growth factor by p53 (2011)
  • Author(s): Sasaki Y, Negishi H, Idogawa M, Yokota I, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T
  • Journal Title: Cancer Research Volume: 71 Pages: 7038-47
  • DOI: 10.1158/0008-5472.can-11-1053
  • Peer Reviewed
• [Journal Article] Statin-mediated reduction of osteopontin expression induces a poptosis and cell growth arrest in ovarian clear cell earcinoma (2011)
  • Author(s): Matsuura M, Suzuki T, Suzuki M, Tanaka R, Ito E, Saito T
  • Journal Title: Oncol Rep Volume: 25(1) Pages: 41-7
  • DOI: 10.3892/or_00001039
  • Peer Reviewed
• [Journal Article] Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma. (2011)
  • Author(s): Suzuki T, Saito T
  • Journal Title: Oncol Rep Volume: 25 Pages: 41-7
  • Peer Reviewed
• [Journal Article] BAG3 (BCL2-associated athanogene 3) interacts with MMP-2 to positively regulate invasion by ovarian carcinoma cells. (2011)
  • Author(s): Iwasaki M, Saito T
  • Journal Title: Cancer Lett Volume: 303 Pages: 65-71
  • Peer Reviewed
• [Journal Article] Successful uterus-preserving surgery for treatment of chemotherapy-resistant placenta increta (2010)
  • Author(s): Endo T, Hayashi T, Shimizu A, Matsuura M, Mizuuchi M, Nagasawa K, Ezaka Y, Baba T, Ishioka S, Saito T
  • Journal Title: Gynecol Obstet Invest Volume: 69(2) Pages: 112-5
  • DOI: 10.1159/000262320
  • Peer Reviewed
• [Journal Article] Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy (2010)
  • Author(s): Matsuura M, Suzuki T, Saito T
  • Journal Title: Cancer Sci Volume: 101(8) Pages: 1828-33
  • DOI: 10.1111/j.1349-7006.2010.01615.x
  • NAID: 10027830539
  • Peer Reviewed
• [Journal Article] Prediction of histologic type and lymph node metastasis for advanced ovarian cancer on uterine cervical and endometrial cytology (2010)
  • Author(s): Suzuki M, Suzuki T, Matsuura M, Iwasaki M, Tanaka R, Ito E, Fujii M, Saito T
  • Journal Title: Acta Cytol Volume: 54(4) Pages: 575-81
  • DOI: 10.1159/000325180
  • Peer Reviewed
• [Journal Article] Remarkable features of ovarian morphology and reproductive hormones in insulin-resistant Zucker fatty(fa/fa) rats (2010)
  • Author(s): Honnma H, Endo T, Kiya T, Shimizu A, Nagasawa K, Baba T, Fujimoto T, Henmi H, Kitajima Y, Manase K, Ishioka S, Ito E, Saito T
  • Journal Title: Reprod Biol Endocrinol Volume: 8 Pages: 73-73
  • DOI: 10.1186/1477-7827-8-73
  • Peer Reviewed
• [Journal Article] Changes of uterine blood flow after vaginal radical trachelectomy(VRT) in patients with early-stage uterine invasive cervical cancer (2010)
  • Author(s): Umemura K, Ishioka S, Endo T, Baba T, Ezaka Y, Nagasawa K, Takahashi M, Mizuuchi M, Iwami N, Adachi H, Takeda N, Tamagawa M, Saito T
  • Journal Title: Int J Med Sci Volume: 7 Pages: 260-6
  • DOI: 10.7150/ijms.7.260
  • Peer Reviewed
• [Journal Article] Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy. (2010)
  • Author(s): Suzuki T, Saito T
  • Journal Title: Cancer Sci Volume: 101 Pages: 1828-33
  • NAID: 10027830539
  • Peer Reviewed
• [Journal Article] A case-control study of endometrial cancer especially with reference to lifestyle and other factors of Japanese women (2009)
  • Author(s): Asakura S, Mori M, Suzuki T, Saito T
  • Journal Title: Sapporo Medical Journal Volume: 78 Pages: 1-6
  • NAID: 120005941846
  • Peer Reviewed
• [Journal Article] The contributions ofresistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population (2009)
  • Author(s): Baba T, Endo T, Sata F, Nagasawa K, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Moriwaka O, Kamiya H, Yamada H, Minakami H, Kishi R, Saito T
  • Journal Title: Gynecol Endocrinol Volume: 25(8) Pages: 498-503
  • DOI: 10.1080/09513590902972042
  • Peer Reviewed
• [Journal Article] Outcomes of planned delivery delay in pregnant patients with invasive gynecologic cancer (2009)
  • Author(s): Ishioka S, Ezaka Y, Endo T, Nagasawa K, Shimizu A, Sato A, Inoue M, Saito T
  • Journal Title: Int J Clin Oncol Volume: 14(4) Pages: 321-5
  • DOI: 10.1007/s10147-008-0861-4
  • NAID: 10025864101
  • Peer Reviewed
• [Journal Article] Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma : incidental pregnancy triggers a catastrophic event (2009)
  • Author(s): Baba T, Endo T, Kitajima Y, Kamiya H, Moriwaka O, Saito T
  • Journal Title: Fertil Steril Volume: 92(1) Pages: 1-3
  • DOI: 10.1016/j.fertnstert.2009.02.071
  • Peer Reviewed
• [Journal Article] Chemotherapy(CT) with radiotherapy versus CT alone for FIGO Stage IIIc endometrial cancer (2009)
  • Author(s): Matsuura M, Suzuki T, Morishita M, Tanaka R, Ito E, Saito T
  • Journal Title: Eur J Gynaecol Oncol Volume: 30 Pages: 40-4
  • Peer Reviewed
• [Journal Article] Chemotherapy(CT)with radiotherapy versus CT alone for FIGO Stage IIIc endometrial cancer (2009)
  • Author(s): Saito T
  • Journal Title: Eur J Gynaecol Oncol. 30 Pages: 40-44
  • Peer Reviewed
• [Journal Article] Spontaneous ovarian hyperstimulation syndrome and pituitary adenoma : incidental pregnancy triggers a catastrophic event (2009)
  • Author(s): Saito T
  • Journal Title: Fertil Steril 25 Pages: 498-503
  • Peer Reviewed
• [Presentation] Osteopontin as a potential molecular target for ovarian clear cell carcinoma therapy (2011)
  • Author(s): Saito T, Iwasaki M
  • Organizer: ASCO Annual Meeting
  • Place of Presentation: Chicago, Ilinois
• [Presentation] オステオポンチンによる卵巣明細胞癌治療の可能性 (2010)
  • Author(s): 鈴木孝浩・松浦基樹・鈴木美和・田中綾一・伊東英樹・藤井美穂・斉藤豪
  • Organizer: 第48回日本婦人科腫瘍学会学術講演会
  • Place of Presentation: つくば
• [Presentation] 癌細胞におけるBAG3発現の意義 (2009)
  • Author(s): 斎藤豪
  • Organizer: 第41回日本臨床分子形態学会
  • Place of Presentation: 神戸市
  • Year and Date: 2009-09-05
• [Presentation] 卵巣癌におけるBAG3遺伝子発現 (2009)
  • Author(s): 鈴木美和・岩崎雅宏・松浦基樹・池田桂子・梅村康太・田中綾一・鈴木孝浩・伊東英樹・斉藤豪
  • Organizer: 第48回日本臨床細胞学会学術総会(日本臨床細胞学会)
  • Place of Presentation: 福岡