| Project/Area Number |
21592142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
SATOH Hiroaki 福島県立医科大学, 医学部, 准教授 (20323595)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIDORIKAWA Sanae 福島県立医科大学, 医学部, 講師 (10325962)
WATANABE Tsuyoshi 福島県立医科大学, 医学部, 講師 (80158641)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | 更年期医学 / インスリン抵抗性 / アディポサイトカイン / 糖尿病 / 動物 / シグナル伝達 |
|---|
| Research Abstract |
To investigate the physiological role of Adipo and Res in the postmenopausal, estrogen-deficient state, we studied the chronic in vivo effect of Adipo and Res on insulin sensitivity in young ovariectomized female Wistar rats. Estrogen-deficient state had significantly increased body weight and decreased insulin sensitivity. Adiponectin improves the estrogen deficiency induced insulin resistance, whereas resistin exacerbates the estrogen deficiency induced insulin resistance. Furthermore, we found that AMPK is a key molecule player in muscle and liver.
These results that the insulin resistance has been involved in the incidence of diabetes increases as women age, especially after menopause.
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