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Analysis of carbohydrate structures related to metastasis of gynecologic cancers and establishment of human monoclonal antibodies towards these carbohydrate structures

Research Project

Project/Area Number 21592145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

SUZUKI Atsushi  慶應義塾大学, 医学部, 助教 (00255514)

Co-Investigator(Kenkyū-buntansha) TOMINAGA Eiichiro  慶應義塾大学, 医学部, 助教 (80276328)
SUZUKI Masami  慶應義塾大学, 医学部, 共同研究員 (10276321)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords婦人科癌 / 抗体医療 / 糖鎖抗原 / モノクローナル抗体 / リンパ節転移 / ヒトモノクローナル抗体
Research Abstract

We have developed a gynecologic cancer-specific human monoclonal antibody HMOCC-1 that demonstrates anti-tumor activity towards ovarian cancer, among gynecologic cancers. The antibody has a specific carbohydrate antigen epitope that is a sulfated carbohydrate moiety. The carbohydrate antigen recognized by this antibody is a newly characterized epitope present on gynecologic cancers and its glycan structure was elucidated to be SO3→3Galβ1→4GlcNAcβ1→3(±SO3→6) Galβ1→4GlcNAcβ1→.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (38 results)

All 2012 2011 2010 2009

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (22 results)

  • [Journal Article] Identification of mono-and di-sulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer2012

    • Author(s)
      Shibata T, Matsumura F, Wang P, Yu SY, Khoo KH, Kitayama K, Akama T, Sugihara K, Kojima-Aikawa K, Seeberger P, Fukuda M, Suzuki A, Aoki D, Fukuda MN
    • Journal Title

      J. Biol Chem

      Volume: 287(9) Pages: 6592-6602

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of ANXA4, PSAT1, CRABP2 and SPB5 as histology-specific biomarker candidates for ovarian cancer by proteomic characterization2012

    • Author(s)
      Toyama A, Suzuki A, Shimada T, Aoki C, Aoki Y, Umino Y, Nakamura Y, Aoki D, Sato T
    • Journal Title

      Cancer Sci

      Volume: 103(4) Pages: 747-55

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers2012

    • Author(s)
      Toyama A, Suzuki A, et al
    • Journal Title

      Cancer Sci.

      Volume: 103(4) Pages: 747-755

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of mono- and disulfated N-acetyl-lactosaminyl oligosaccharide structures as epitopes specifically recognized by humanized monoclonal antibody HMOCC-1 raised against ovarian cancer2012

    • Author(s)
      Shibata TK, Matsumura F, Suzuki A, et al
    • Journal Title

      J Biol.Chem.

      Volume: 287(9) Issue: 9 Pages: 6592-6602

    • DOI

      10.1074/jbc.m111.305334

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HNK-1 glycan functions as a tumor suppressor for astrocytic tumor2011

    • Author(s)
      Suzuki-Anekoji M, Suzuki M, Kobayashi T, Sato Y, Nakayama J, Suzuki A, Bao X, Angata K, Fukuda M
    • Journal Title

      J. Biol Chem

      Volume: 286(37) Pages: 32824-33

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer2011

    • Author(s)
      Kataoka F, Tsuda H, Nomura H, Chiyoda T, Tominaga E, Suzuki A, Susumu N, Aoki D
    • Journal Title

      Eur J Gynaecl Oncol

      Volume: 32(2) Pages: 160-3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The chemosensitivity of nodal metastases in recurrent epithelial ovarian cancer2011

    • Author(s)
      Kataoka F, Tsuda H, Suzuki A, et al
    • Journal Title

      Eur J.Gynaecol.Oncol.

      Volume: 32(2) Pages: 160-163

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HNK-1 glycan functions as a tumor suppressor for astrocytic tumor2011

    • Author(s)
      Suzuki-Anekoji M, Suzuki M, Suzuki A, et al
    • Journal Title

      J Biol.Chem.

      Volume: 286(37) Pages: 32824-32833

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of third-line chemotherapy for women with recurrent ovarian cancer who received platinum/taxane regimens as first-line chemotherapy2010

    • Author(s)
      Chiyoda T, Tsuda H, Nomura H, Kataoka F, Tominaga E, Suzuki A, Susumu N, Aoki D
    • Journal Title

      Eur J Gynaecol Oncol

      Volume: 31(4) Pages: 364-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lymph node metastasis in grossly apparent stages I and II epithelial ovarian cancer2010

    • Author(s)
      Nomura H, Tsuda H, Susumu N, Fujii T, Banno K, Kataoka F, Tominaga E, Suzuki A, Chiyoda T, Aoki D
    • Journal Title

      Int J Gynecol Cancer

      Volume: 3 Pages: 341-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The sensitivity and specificity of a new formula to distinguish endometrioid type endometrial carcinoma from ovarian endometrial carcinoma2010

    • Author(s)
      Nishimura S, Ito YM, Tsuda H, Ohnishi Y, Kataoka F, Nomura H, Chiyoda T, Suzuki A, Susumu N, Aoki D, Hatae M
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 148(1) Pages: 67-72

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amplification of GNAS may be an independent, qualitative and reproducible biomarker to predict progression-free survivial in epithelial ovarian cancer2010

    • Author(s)
      Tominaga E, Tsuda H, Arao T, Nishimura S, Takano M, Kataoka F, Nomura H, Hirasawa A, Aoki D, Nishio K
    • Journal Title

      Gynecol. Oncol

      Volume: 118(2) Pages: 160-6

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of third-line chemotherapy for women with recurrent ovarian cancer who received platinum/taxane regimens as first-line chemotherapy2010

    • Author(s)
      Chiyoda T, Tsuda H, Suzuki, A, et al.
    • Journal Title

      Eur J.Gynaecol.Oncol.

      Volume: 31(4) Pages: 364-368

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymph node metastasis in grossly apparent stages I and II epithelial ovarian cancer2010

    • Author(s)
      Nomura H, Tsuda H, Suzuki, A, et al.
    • Journal Title

      Int.J.Gynecol.Cancer

      Volume: 20(3) Pages: 341-345

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amplification of GNAS may be an independent, qualitative and reproducible biomarker to predict progression-free survivial in epithelial ovarian cancer2010

    • Author(s)
      Tominaga E, Tsuda H, et al.
    • Journal Title

      Gynecol.Oncol.

      Volume: 118 Pages: 160-166

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The sensitivity and specificity of a new formula to distinguish endometroid type endometrial carcinoma from ovarian endometrial carcinoma2010

    • Author(s)
      Nishimura, S., Suzuki, A, et al.
    • Journal Title

      Eur J.Obstet Gynecol.Reprod Biol 148(1)

      Pages: 67-72

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Novel function of HNK-1 sulfotransferase as a hormone regulator2011

    • Author(s)
      Suzuki-Anekoji M
    • Organizer
      Annual Meeting for the Society for Glycobiology
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] HNK-1 glycan functions as a tumor suppressor for astrocytic tumor2011

    • Author(s)
      Suzuki-Anekoji M
    • Organizer
      Annual Meeting for the Society for Glycobiology
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Novel function of HNK-1 sulfotransferase as a hormone regulator2011

    • Author(s)
      Suzuki-Anekoji M(共同演者:鈴木淳)
    • Organizer
      Annul Meeting for the Society for Glycobiology
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] HNK-1 glycan functions as a tumor suppressor for astrocytic tumor2011

    • Author(s)
      Suzuki-Anekoji M(共同演者:鈴木淳)
    • Organizer
      Annul Meeting for the Society for Glycobiology
    • Place of Presentation
      Seattle, WA, USA
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌の各組織型におけるANXA4, SPB5, CRABP2, PST1分子発現とバイオマーカーとしての有用性2011

    • Author(s)
      遠山敦彦
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      国際会議場、名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌の各組織型におけるANXA4,SPB5,CRABP2,PST1分子発現とバイオマーカーとしての有用性2011

    • Author(s)
      遠山敦彦(共同演者:鈴木淳)
    • Organizer
      第70回日本癌学会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌の組織型特異的なバイオマーカーの開発と血清診断の可能性2011

    • Author(s)
      遠山敦彦
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ、横浜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌間質の遺伝子解析を用いた新規バイオマーカーの検索ー癌間質のEGR-1発現は上皮性卵巣癌の予後と相関する2011

    • Author(s)
      片岡史夫
    • Organizer
      第63回日本産婦人科学会総会学術講演会
    • Place of Presentation
      国際会議場、大阪
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] シアリダーゼ発現低下は卵巣癌腹膜播種を抑制する2011

    • Author(s)
      野村弘行
    • Organizer
      第63回日本産婦人科学会総会学術講演会
    • Place of Presentation
      国際会議場、大阪
    • Year and Date
      2011-08-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 卵巣癌間質の遺伝子解析を用いた新規バイオマーカーの検索-癌間質のEGR-1発現は上皮性卵巣癌の予後と相関する2011

    • Author(s)
      片岡史夫(共同演者:鈴木淳)
    • Organizer
      第63回日本産婦人科学会総会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] シアリダーゼ発現低下は卵巣癌腹膜播種を抑制する2011

    • Author(s)
      野村弘行(共同演者:鈴木淳)
    • Organizer
      第63回日本産婦人科学会総会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 絨毛癌におけるSOX遺伝子群の発現検索と新規治療標的の可能性2011

    • Author(s)
      冨永英一郎
    • Organizer
      第50回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      札幌コンベンションセンター、(北海道)
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトモノクローナル抗体HMMC-1は癌の増殖に対して抑制的に作用する2010

    • Author(s)
      笈川文子
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学学会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Year and Date
      2010-12-07
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Fertility-preserving high-dose medroxy-progesterone acetate(MPA) therapy for 4 young patients with grade 2 endometrioid adenocarcinoma2010

    • Author(s)
      進伸幸
    • Organizer
      13^<th> Bienniel Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2010-10-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Fertility-preserving high dose medroxyprogesterone acetate (MPA) therapy for 4 young Patient with grade 2 endometrioid adencarcinoma2010

    • Author(s)
      進伸幸(共同演者:鈴木淳)
    • Organizer
      13^<th> Bienniel Meeting of the International Gynecologic Cancer Society
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression of ANXA4, SPB5, CRABP2, and PSAT1 in ovarian cancer histological subtypes used for diagnostic purposes2010

    • Author(s)
      遠山敦彦
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      国際会議場、大阪
    • Year and Date
      2010-09-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 標準治療を施行した上皮性卵巣癌を規定する遺伝子の探索2010

    • Author(s)
      冨永英一郎
    • Organizer
      第9回日本婦人科がん分子標的研究会
    • Place of Presentation
      大津プリンスホテル、滋賀
    • Year and Date
      2010-09-10
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] GNAS遺伝子の増幅は標準治療を施行した上皮性卵巣癌の独立した予後因子である2010

    • Author(s)
      冨永英一郎
    • Organizer
      第62回日本産婦人科学会学術講演会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2010-04-23
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 子宮体癌細胞が発現している糖タンパク質と転移性の関連2009

    • Author(s)
      笈川文子
    • Organizer
      Glyco Tokyo 2009シンポジウム
    • Place of Presentation
      お茶の水大学、東京
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Lymph node metastasis in grossly stage I and II epithelial ovarian cancer2009

    • Author(s)
      野村弘行
    • Organizer
      16^<th> International Meeting of the European Society of Gynecologic Oncology
    • Place of Presentation
      Belgrade, Serbia
    • Year and Date
      2009-11-12
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] 卵巣癌の組織型特異的なバイオマーカーの開発と血清診断の可能性2009

    • Author(s)
      遠山敦彦(共同演者:鈴木淳)
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ、横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] 標準治療を受けた表層上皮性卵巣癌の再発リスクを規定する遺伝子の検索2009

    • Author(s)
      冨永英一郎
    • Organizer
      第61回日本産科婦人科学術集会
    • Place of Presentation
      国際会議場、京都
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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