Uterine cervical carcinogenesis in TGF-alpha transgenic mice
| Project/Area Number |
21592150
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Hospital Organization Shikoku Cancer Center |
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Principal Investigator |
SHIROYAMA Yuko 独立行政法人国立病院機構四国がんセンター(臨床研究センター), その他部局等, その他 (60397982)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Takashi 愛媛大学, 医学系研究科, 講師 (20346670)
IGUCHI Haruo 独立行政法人 国立病院機構 四国がんセンター, 臨床研究センター, センタ−長 (90393438)
UEDA Norifumi 愛媛大学, 医学研究科, 教授 (30030886)
SUGITA Atsuro 愛媛大学, 医学部附属病院, 准教授 (60179140)
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| Project Period (FY) |
2009-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 子宮頸癌 / 動物モデル / トランスジェニックマウス / 腫瘍発生 / TGF-α / ﾄﾗﾝｽｼﾞｪﾆｯｸﾏｳｽ |
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| Research Abstract |
HPV (human papilloma viruses)-infection appears to be insufficient for carcinogenesis, because most lesions in human cervical squamous epithelium containing high-risk HPVs do not progress to invasive carcinoma. The other genetic alterations in addition to HPV-infection may be also important for cervical carcinogenesis. TGF-alpha overexpression is observed in 10-50% of cervical cancers. In this study, we examined the impact of elevated TGF-alpha in cervical epithelium of TGF-alpha transgenic mice. The incidence of cervical intraepithelial neoplasias (CINs) was 38% (6/16) in TGF-alpha transgenic mice. Invasive carcinoma was not observed. These findings suggest that constitutive expression of TGF-alpha and activation of the epidermal growth factor receptor in epithelium of uterine cervix may play an important role in tumorigenesis in this tissue.
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Report
(6 results)
Research Products
(12 results)
