| Project/Area Number |
21592151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NANBA Atsushi 弘前大学, 医学部附属病院, 講師 (50361027)
SHIRASAKI Takashi 弘前大学, 医学部附属病院, 医員 (20419980)
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| Research Collaborator |
NISHIZAWA Hisanori 弘前大学, 大学院・医学研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 好酸球性中耳炎 / periostin / 動物モデル / pendrin |
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| Research Abstract |
We investigated the clinical risk factors of Eosinophlic Otitis Media (EOM) and established the diagnostic criteria of EOM. Moreover, we investigated the localization of periostin, an extracellular matrix protein, in middle ear specimens of eosinophlic otitis media (EOM) patients accompanied and of a newly constructed animal model for EOM. Periostin-positive immunostaining was observed in the middle ear sections obtained from the EOM patients with/without asthma. In the animal model, immunoreactivity for periostin was also seen. These results suggested that periostin plays an important role in subepithelial fibrosis in the middle ear of EOM.
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