Understanding the functional disorders of the auditory organ and development of effective treatment methods
| Project/Area Number |
21592152
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | The University of Electro-Communications |
|---|
Principal Investigator |
KOIKE Takuji 電気通信大学, 大学院・情報理工学研究科, 教授 (10282097)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 聴覚器 / シミュレーション / 振動解析 / 病変発現機序 / 内耳 / イオンチャネル / 外リンパ瘻 / イオン輸送 / 人工内耳 |
|---|
| Research Abstract |
A finite-element model of the active cochlea was constructed with considering the outer hear cell(OHC) motility, and the effects of the OHC on hearing ability were investigated. In addition, by modeling the ion channels of the inner hear cells(IHCs), the OHCs and the cells which compose the stria vascularis and the spiral ligament of cochlear duct, the time-domain response of the membrane potential of the hair cells and endocochlear potential(EP) was simulated with changing the vibration amplitude and frequency applied to the stereocilia. The EP decreased when the function of each channel was impaired, and the functional loss of the hair cells was caused by the change of the EP.
|
Report
(4 results)
Research Products
(31 results)
