The Relationship between Aging and Heat Shock Response in the Inner Ear
| Project/Area Number |
21592157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIMOGORI Hiroaki 山口大学, 大学院・医学系研究科, 准教授 (70226273)
SUGAHARA Kazuma 山口大学, 医学部附属病院, 講師 (20346555)
MIKURIYA Takefumi 山口大学, 医学部附属病院, 助教 (00467797)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 内耳 / 老化 / 熱ショック蛋白質 / 加齢 / 熱ショック応答 |
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| Research Abstract |
Mechanisms of age-related hearing loss have not been elucidated as aging processes are extremely complex. We examined age-related expression of HSPs in the cochlea of animal model of age-related hearing loss. The results showed that the mice showed weakening expression of Hsp70 and Hsp110 with age. In addition, we showed that hearing loss deteriorated in HSF1 null mice. These results demonstrate that the heat shock responses have a grate role in the age-related hearing loss
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Report
(4 results)
Research Products
(57 results)
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[Journal Article]2009
Author(s)
山下裕司, 菅原一真
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Journal Title
炎症・再生医学事典再生医学-体性幹細胞と組織修復-耳鼻咽喉(朝倉書店)
Pages: 450-452
Related Report
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[Presentation] Vestibular Research and AMPA2012
Author(s)
Syuhei Yoshida, Hiroaki Shimogori, Hideki Toyota, Kazuma Sugahara, Hiroshi Yamashita
Organizer
35th Annual MidWinter ResearchMeeting of the Association for Research in Otolaryngology
Place of Presentation
San Diego(USA)
Year and Date
2012-02-25
Related Report
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[Presentation] Makoto Hashimoto, Takuo Ikeda, Kazuma Sugahara, Hironori Fujii, Hiroaki Shimogori, Hiroshi Yamashita : Analysis of the Eye Movement by Original Video-Oculography, HI-VOG2012
Author(s)
Makoto Hashimoto, Takuo Ikeda, Kazuma Sugahara, Hironori Fujii, Hiroaki Shimogori, Hiroshi Yamashita
Organizer
35th Annual MidWinter Research Meeting of the Association for Research in Otolaryngology
Place of Presentation
San Diego(USA)
Year and Date
2012-02-25
Related Report
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