Apotosis expressed in the experimental middle ear cholesteatoma

• Project/Area Number: 21592158
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Showa University
• Principal Investigator: HINOHIRA Yasuyuki 昭和大学, 医学部, 講師 (00238320)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 中耳真珠腫 / 実験モデル / アポトーシス / 組織学的検討

Research Abstract

Middle ear cholesteatoma is an intractable disease which has strong epithelial proliferation potency and destroys the surrounding organs. The pathogenesis of cholesteatoma is still controversial, and the recurrence rate is high. This study demonstrates apotosis plays some roles in dysfunction of the epithelial proliferation, using experimental animal models.

Research Products

• [Journal Article] 慢性中耳炎 (2011)
  • Author(s): 比野平恭之
  • Journal Title: MB ENT Volume: 131 Pages: 21-24
• [Journal Article] Lateral orifice of Prussak's space assessed with a high-resolution cone beam 3-dimensional computed tomography (2011)
  • Author(s): Kashiba K, Komori M, Yanagihara N, Hinohira Y, Sakagami M
  • Journal Title: Otology & Neurotology Volume: 32 Pages: 71-76
  • Peer Reviewed
• [Journal Article] 真珠腫性中耳炎の進展度分類 (2010)
  • Author(s): 比野平恭之
  • Journal Title: JOHNS Volume: 26 Pages: 1041-1043
• [Journal Article] Residual recurrence following staged canal wall up tympanoplasty for middle ear cholesteatoma (2010)
  • Author(s): Hinohira Y, Yanagihara N, Komori M
  • Journal Title: Laryngoscope Volume: 120
• [Journal Article] Residual recurrence following staged canal wall up tympanoplasty for middle ear cholesteatoma. (2010)
  • Author(s): Hinohira Y, Yanagihara N, Komori M.
  • Journal Title: Laryngoscope Volume: 120 Pages: 74-74
• [Journal Article] Lateral orifice of prussak's space assessed witha high-resolution conebeam 3-dimensional computed tomography. (2010)
  • Author(s): Kashiba K, Komori M, Yanagihara N, Hinohira Y, Sakagami M.
  • Journal Title: Otol Neurotol Volume: 32 Pages: 71-76
  • Peer Reviewed
• [Journal Article] Total mastoid obliteration in staged canal-up tympanoplasty for cholesteatoma facilitates tympanic aeration (2009)
  • Author(s): Yanagihara N, Komori M, Hinohira Y
  • Journal Title: Otology & Neurotology Volume: 30 Pages: 766-770
  • Peer Reviewed
• [Journal Article] Total mastoid obliteration in staged canal-up tympanoplasty for cholesteatoma facilitates tympanic aeration (2009)
  • Author(s): Yanagihara N, Komori M, Hinohira Y.
  • Journal Title: Otology & Neurotology 30 Pages: 776-770
  • Peer Reviewed
• [Journal Article] Staging of tympanoplasty in cholesteatoma : Does the use of reconstruction techniques regarding the scutum defect and the mastoid cavity influence the staging? (2009)
  • Author(s): Hinohira Y, Yanagihara N, Komori M, Gyo K.
  • Journal Title: Surgery of the ear-Current topics Pages: 284-288
• [Journal Article] Postoperative management and revision surgery for cholesteatoma (2009)
  • Author(s): Hinohira Y, Yanagihara N, Komori M, Gyo K.
  • Journal Title: Surgery of the ear-Current topics Pages: 334-338
• [Presentation] 耳鼻咽喉科手術と3D画像システム (2011)
  • Author(s): 比野平恭之
  • Organizer: 第112回日本耳鼻咽喉科学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2011-05-21
• [Presentation] 耳鼻咽喉科手術と3D画像システム (2011)
  • Author(s): 比野平恭之
  • Organizer: 第112回日本耳鼻咽喉科学会総会
  • Place of Presentation: 京都
• [Presentation] 鼓膜真珠腫症例の検討 (2010)
  • Author(s): 高橋郷, 山田尚弘, 比野平恭之, 小林一女, 洲崎春海
  • Organizer: 第20回日本耳科学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2010-10-07
• [Presentation] 側頭骨画像診断 (2010)
  • Author(s): 比野平恭之
  • Organizer: 第20回日本耳科学会総会
  • Place of Presentation: 松山市
  • Year and Date: 2010-10-07
• [Presentation] Modified staged tympanoplasty for severe tympanosclerosis. (2010)
  • Author(s): Hinohira Y, Yanagihara N, Komori M, Suzaki H.
  • Organizer: 2010 AAO-HNSF Annual Meeting & OTO EXPO
  • Place of Presentation: Boston, USA
  • Year and Date: 2010-09-28
• [Presentation] Residual recurrence following staged canal wall up tympanoplasty for middle ear cholesteatoma. (2010)
  • Author(s): Furuya A, Hinohira Y, Katsuno M, Suzaki H.
  • Organizer: The 13th KOREA- JAPAN Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-09-09
• [Presentation] 乳突洞進展をきたした原発性外耳道真珠腫の一例 (2010)
  • Author(s): 庄司育夫, 比野平恭之, 山田尚弘, 洲崎春海
  • Organizer: 第72回耳鼻咽喉科臨床学会総会
  • Place of Presentation: 倉敷市
  • Year and Date: 2010-07-02
• [Presentation] Residual recurrence following staged canal wall up tympanoplasty for middle ear cholesteatoma. (2010)
  • Author(s): Hinohira Y, Yanagihara N, Komori M.
  • Organizer: The 113th annual meeting of the Triological Society
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2010-04-29
• [Presentation] Modified staged tympanoplasty for severe tympanosclerosis (2010)
  • Author(s): Hinohira Y, Yanagihara N, Komori M, Suzaki H
  • Organizer: 2010 AAO-HNSF Annual Meeting & OTO EXPO
  • Place of Presentation: Boston, USA
• [Presentation] Residual recurrence following staged canal wall up tympanoplasty for middle ear cholesteatoma (2010)
  • Author(s): Furuya A, Hinohira Y, Katsuno M, Suzaki H
  • Organizer: The 13th KOREA-JAPAN Joint Meeting of Otorhinolaryngology Head and Neck Surgery
  • Place of Presentation: Seoul, Korea
• [Presentation] Residual recurrence following staged canal wall up tympanoplasty for middle ear cholesteatoma (2010)
  • Author(s): Hinohira Y, Yanagihara N, Komori M, Hato N
  • Organizer: The 113th annual meeting of the Triological Society
  • Place of Presentation: Las Vegas, USA
• [Presentation] 鼓膜真珠腫症例の検討 (2010)
  • Author(s): 高橋郷, 山田尚弘, 比野平恭之, 小林一女, 洲崎春海
  • Organizer: 第20回日本耳科学会総会
  • Place of Presentation: 松山
• [Presentation] 進展度分類に応じた真珠腫に対する鼓室形成術 (2009)
  • Author(s): 比野平恭之
  • Organizer: 第71回耳鼻咽喉科臨床学会総会
  • Place of Presentation: 旭川
  • Year and Date: 2009-07-02
• [Presentation] 後壁保存鼓室形成術後の遺残性真珠腫に対する手術 (2009)
  • Author(s): 比野平恭之, 柳原尚明, 小森正博, 羽藤直人
  • Organizer: 第19回日本耳科学会総会
  • Place of Presentation: 東京