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Vestibular functions at the Meniere's attack and after treatment

Research Project

Project/Area Number 21592159
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionThe University of Tokyo

Principal Investigator

KAKIGI Akinobu  東京大学, 医学部附属病院, 講師 (60243820)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsメニエール病 / 内リンパ水腫 / 抗利尿ホルモン / めまい発作 / 自発眼振 / 前庭機能
Research Abstract

We produced a new animal model for Meniere’s disease. This model consists of hypo-function of endolymphatic sac and administration of vasopressin. This model showed larger endolymphatic hydrops than those of hypo-function of endolymphatic sac only and administration of vasopressin only. Moreover, this model showed spontaneous nystagmus and balance disorder. These results indicate that hypo-function of endolymphatic sac in combination with high plasma level of vasopressin would induce vertiginous attack of Meniere’s disease. Further, we administered V2R antagonist to the new animal model for Meniere’s disease. The animal showed decrease in endolymphatic hydrops and did not show spontaneous nystagmus or balance disorder. This result implies that V2R antagonist might be used for a treatment of Meniere’s disease.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (44 results)

All 2013 2012 2011 2010 2009

All Journal Article (13 results) (of which Peer Reviewed: 5 results) Presentation (31 results)

  • [Journal Article] Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene receptor antagonist.2012

    • Author(s)
      Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R, Yamasoba T.
    • Journal Title

      Otol Neurotol.

      Volume: 33(5) Issue: 5 Pages: 886-90

    • DOI

      10.1097/mao.0b013e3182565a27

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear.2012

    • Author(s)
      Takumida M, Kakigi A, Egami N, Nishioka R, Anniko M.
    • Journal Title

      Acta Otolaryngol

      Volume: 132 Pages: 807-813

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Type 1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene receptor antagonist.2012

    • Author(s)
      Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R, Yamasoba T.
    • Journal Title

      Otol Neurotol

      Volume: 33 Pages: 886-890

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocytosis of cationized ferritin in marginal cells of the stria vascularis is regulated by protein kinase, protein phosphatase, and MEK/ERK and PI3-K signaling pathways.2011

    • Author(s)
      Kakigi A , Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T.
    • Journal Title

      Otol Neurotol.

      Volume: 32(5) Issue: 5 Pages: 85662-85662

    • DOI

      10.1097/mao.0b013e318210b8ad

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endocytosis of microperoxidase in marginal cells is mainly regulated by RhoA signaling cascade, but not by Rho-associated protein kinase, myosin light-chain kinase and myosin phosphatase.2011

    • Author(s)
      Kakigi A , Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec.

      Volume: 73(1) Issue: 1 Pages: 1-8

    • DOI

      10.1159/000321117

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endocytosis of cationized ferritin in marginal cells of the stria vascularis is regulated by protein kinase, protein phosphatase, and MEK/EEK and PI3-K signaling pathways2011

    • Author(s)
      Kakigi A, Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T
    • Journal Title

      Otol Neurotol

      Volume: 32 Pages: 856-862

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endocytosis of microperoxidase in marginal cells is mainly regulated by RhoA signaling cascade, but not by Rho-associated protein kinase, myosin light-chain kinase and myosin phosphatase2011

    • Author(s)
      Kakigi A, Okada T, Takeda T, Takeda S, Nishioka R, Taguchi D, Nishimura M, Yamasoba T
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 73 Pages: 1-8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The clinical value of extratympanic electrocochleography in the diagnosis of Meniere's disease.2010

    • Author(s)
      Takeda T, Kakigi A.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec.

      Volume: 72(4) Issue: 4 Pages: 196-204

    • DOI

      10.1159/000315552

    • Related Report
      2012 Final Research Report
  • [Journal Article] Endocytosis of MPO in marginal cells is regulated by PKC, protein phosphatase, ERK and PI3-K signaling cascades, but not by PKA and MEK signaling cascades.2010

    • Author(s)
      Kakigi A , Okada T, Takeda T, Takeda S, Taguchi D, Nishimura M, Yamasoba T.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec

      Volume: 72(4) Issue: 4 Pages: 188-95

    • DOI

      10.1159/000314697

    • Related Report
      2012 Final Research Report
  • [Journal Article] Time course of vestibular function changes of experimental endolymphatic hydrops in guinea pigs.2010

    • Author(s)
      Kakigi A , Taguchi D, Takeda T, Takeda S, Nakatani H.
    • Journal Title

      ORL J Otorhinolaryngol Relat Spec.

      Volume: 1 Pages: 19-25

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expression of aquaporins and vasopressin type 2 receptor in the stria vascularis of the cochlea.2010

    • Author(s)
      Nishioka R, Takeda T, Kakigi A , Okada T, Takebayashi S, Taguchi D, Nishimura M, Hyodo M.
    • Journal Title

      Hear Res.

      Volume: 260(1-2) Pages: 11-9

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expression of aquaporins, vasopressin type 2 receptor, and Na+_K+_Cl^_ cotransporters in the rat endolymphatic sac.2009

    • Author(s)
      Nishimura M, Kakigi A , Takeda T, Takeda S, Doi K.
    • Journal Title

      Acta Otolaryngol.

      Volume: 129(8) Issue: 8 Pages: 812-8

    • DOI

      10.1080/00016480802441754

    • Related Report
      2012 Final Research Report
  • [Journal Article] Time course changes of vasopressin-induced enlargement of the rat intrastrial space and the effects of a vasopressin type 2 antagonist.2009

    • Author(s)
      Nishimura M, Kakigi A , Takeda T, Okada T, Doi K.
    • Journal Title

      Acta Otolaryngol.

      Volume: 129(7) Issue: 7 Pages: 709-15

    • DOI

      10.1080/00016480802419115

    • Related Report
      2012 Final Research Report
  • [Presentation] Morphological and Functional Changes in a New Animal Model for Meniere's Disease.2013

    • Author(s)
      Egami N, Kakigi A, Takeda T, Yamasoba T.
    • Organizer
      36th Association for Research in Otolaryngology Midwinter Meeting,
    • Place of Presentation
      Maryland,USA,Maryland, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Water Transport in the Rat Inner Ear; Translational Research of Meniere's Disease.2013

    • Author(s)
      Nishimura M, Kakigi A, Takeda T, Takeda S, Okada T, Murata J, Ikeda K.
    • Organizer
      36th Association for Research in Otolaryngology Midwinter Meeting
    • Place of Presentation
      USA, Baltimore, Maryland, USA.
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunolocalization of Aquaporin1 and 2 inThe Rat Vestibule and Semicircular Canal.2012

    • Author(s)
      Kakigi A, Egami N, Sakamoto T, Nishioka R, Takumida M, Hyodo M, Yamasoba T.
    • Organizer
      14th Korea Japan Joint Meeting ofOtorhinolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kyoto, Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] Immunolocalization of Aquaporins and Vasopressin V2 Receptor in The Rat Vestibule and Semicircular Canal.2012

    • Author(s)
      Kakigi A, Egami N, Sakamoto T, Nishioka R, Takumida M, Hyodo M, Yamasoba T.
    • Organizer
      The 1st Asian Otology Meeting & the 3rd East Asian Symposium on Otology.
    • Place of Presentation
      Nagasaki, Japan.
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of aquaporins (AQPs)-10/11/12 in the lateral wall of the rat cochlea.2012

    • Author(s)
      R. Nishioka, T. Takeda, A. Kakigi, M. Komori, T. Kobayashi, M. Hyodo.
    • Organizer
      49th Workshop on Inner Ear Biology.
    • Place of Presentation
      Tubingen, Germany.
    • Related Report
      2012 Final Research Report
  • [Presentation] Cochlear Function in A New Animal Model for Meniere's Disease.2012

    • Author(s)
      Kakigi A, Egami N, Sakamoto T, Yamasoba T.
    • Organizer
      13th International Meeting of Mediterranian Society of Otology and Audiology.
    • Place of Presentation
      Naples, Italy.
    • Related Report
      2012 Final Research Report
  • [Presentation] メニエール病モデル動物におけるV2R拮抗的阻害薬の効果に関する検討2012

    • Author(s)
      江上直也、柿木章伸、竹田泰三、兵頭政光、山岨達也
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット内リンパ嚢におけるAQP11の発現2012

    • Author(s)
      田口大藏、柿木章伸、竹田泰三、北野博也
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] メニエール病モデル動物におけるV2R拮抗的阻害薬の効果に関する検討2012

    • Author(s)
      江上直也、柿木章伸、竹田 泰三、兵頭 政光、山岨 達也
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 「内リンパ水腫と水代謝」 ―基礎から臨床まで―2012

    • Author(s)
      柿木章伸
    • Organizer
      第71回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cochlear Function in A New Animal Model for Meniere’s Disease2012

    • Author(s)
      Kakigi A, Egami N, Sakamoto T, Yamasoba T
    • Organizer
      13th International Meeting of Mediterranian Society of Otology and Audiology
    • Place of Presentation
      Naples, Italy
    • Related Report
      2012 Annual Research Report
  • [Presentation] A new animal model for Meniere's disease2011

    • Author(s)
      Kakigi A, Egami N, Sakamoto T, Nishioka R, Hyodo M, Takeda T, Yamosoba T
    • Organizer
      48th Inner Ear Biology Workshop
    • Place of Presentation
      Lisbon, Portugie
    • Year and Date
      2011-09-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Type-1 Allergy-Induced Endolymphatic Hydrops and the Suppressive Effect of Leukotrien and Histamin Antagonists.2011

    • Author(s)
      Egami N, Kakigi A, Takeda T, Takeda S, Nishioka R, Yamasoba T.
    • Organizer
      The Association for Research in Otolaryngology, 34thMidWinter Research Meeting. Baltimore, Maryland
    • Place of Presentation
      USA
    • Related Report
      2012 Final Research Report
  • [Presentation] A new animalmodel for Meniere's disease.2011

    • Author(s)
      Kakigi A , Egami N, Sakamoto T, Nishioka R,Hyodo M, Takeda T, Yamosoba T.
    • Organizer
      48th InnerEar Biology Workshop.
    • Place of Presentation
      Lisbon, Portugie
    • Related Report
      2012 Final Research Report
  • [Presentation] Vasopressin投与によるラット血管条細胞間隙の経時的変化とVasopressin type 2 antagonist投与における効果.2011

    • Author(s)
      西村将彦、柿木章伸、竹田泰三、土井勝美、兵頭政光
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Final Research Report
  • [Presentation] 内リンパ嚢におけるロイコトリエン受容体の発現について2011

    • Author(s)
      江上直也、柿木章伸、竹田泰三、西岡利恵、山岨達也
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Final Research Report
  • [Presentation] 実験的内リンパ水腫動物にめまいは起きるか?2011

    • Author(s)
      柿木章伸、江上直也、坂本幸士、西岡利恵、兵頭政光、山岨達也
    • Organizer
      第21回日本耳科学会総会・学術講演会
    • Place of Presentation
      沖縄
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Mechanisms underlying theFormation of Endolymphatic Hydrops and itsClinical Pictures.2010

    • Author(s)
      Kakigi A.
    • Organizer
      49th Korean Audiological Society academic meeting
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2010-05-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanisms underlying the Formation of Endolymphatic Hydrops and its Clinical Pictures2010

    • Author(s)
      柿木章伸
    • Organizer
      the 49th Korean Audiological Society academic meeting
    • Place of Presentation
      Hanyang University, Seoul, Korea
    • Year and Date
      2010-05-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Type-1 allergy-induced endolymphatic hydrops and the suppressive effect of anti-allergy drugs.2010

    • Author(s)
      Takeda T, Takeda S, Egami N, Kakigi A, Nishioka R.
    • Organizer
      47th Inner Ear Biology Workshop - Prague
    • Place of Presentation
      Czeck Republic
    • Related Report
      2012 Final Research Report
  • [Presentation] 内リンパ水腫動物の前庭機能(第2報)2010

    • Author(s)
      柿木章伸,江上直也,山岨達也,西岡利恵,竹田泰三
    • Organizer
      第69回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Vestibular Function in A New Animal Model for2010

    • Author(s)
      Kakigi A, Egami N, Sakamoto T, Nishioka R, Hyodo M, Takeda T, Yamasoba T.
    • Organizer
      Sixth International Symposium on Meniere's Disease and Inner Ear Disorders. Kyoto
    • Place of Presentation
      Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット蝸牛血管条における水チャネルの局在.2009

    • Author(s)
      西岡利恵、柿木章伸、兵頭政光
    • Organizer
      第110回日本耳鼻咽喉科学会総会ならびに学術講演
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Vestibular function in a new animal model for Meniere's disease.2009

    • Author(s)
      Kakigi A, Yamasoba T, Takeda T.
    • Organizer
      46th Inner Ear Biology Workshop - Utrecht
    • Place of Presentation
      Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Type-1 allergy-induced endolymphatic hydrops and the suppressive effect of leukotriene antagonist.2009

    • Author(s)
      Takeda T, Takeda S, Kakigi A.
    • Organizer
      46th Inner Ear Biology Workshop - Utrecht
    • Place of Presentation
      Netherlands
    • Related Report
      2012 Final Research Report
  • [Presentation] Bumetanide投与によるラット血管条の形態変化とOPC-31260投与における効果.2009

    • Author(s)
      西村将彦、柿木章伸、竹田泰三、土井勝美
    • Organizer
      第19回日本耳科学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット内耳血管条におけるアクアポリン10~12の発現.2009

    • Author(s)
      西岡利恵、柿木章伸、兵頭政光.
    • Organizer
      第19回日本耳科学会総会・学術講演会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Aquaporins as Potentials Drug Targets for Meniere's disease and its Related Disease.2009

    • Author(s)
      Takeda T, Kakigi A.
    • Organizer
      BIT's 2nd Annual Congress and Expo of Molecular
    • Place of Presentation
      Beijing, China
    • Related Report
      2012 Final Research Report
  • [Presentation] 内リンパ水腫動物の前庭機能2009

    • Author(s)
      柿木章伸、山岨達也、竹田泰三
    • Organizer
      第68回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      徳島市
    • Related Report
      2012 Final Research Report
  • [Presentation] ラット内耳前庭におけるAQPの発現2009

    • Author(s)
      西岡利恵、柿木章伸、兵頭政光
    • Organizer
      第68回日本めまい平衡医学会総会・学術講演会
    • Place of Presentation
      徳島市
    • Related Report
      2012 Final Research Report
  • [Presentation] Vasopressin 投与によるラット血管条の形態変化について(第 3 報)2009

    • Author(s)
      西村将彦、柿木章伸、竹田泰三、土井勝美
    • Organizer
      第68回 日本めまい平衡医学会 総会・学術講演会
    • Place of Presentation
      徳島市
    • Related Report
      2012 Final Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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