Pathogenesis research of pediatric intractable otitis media and viral-bacterial interaction
| Project/Area Number |
21592165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOTOMI Muneki 和歌山県立医科大学, 医学部, 講師 (90336892)
田村 真司 和歌山県立医科大学, 医学部, 講師 (10244724)
戸川 彰久 和歌山県立医科大学, 医学部, 講師 (70305762)
藤原 啓次 和歌山県立医科大学, 医学部, 准教授 (20244725)
島田 純 和歌山県立医科大学, 医学部, 講師 (90326372)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Shinji 和歌山県立医科大学, 医学部, 講師 (10244724)
TOGAWA Akihisa 和歌山県立医科大学, 医学部, 講師 (70305762)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 急性中耳炎 / ヒトBocaウイルス / 肺炎球菌 / ヒトメタニューモウイルス / 中耳炎 / 細菌感染 / ウイルス感染 / ノイラミニダーゼ |
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| Research Abstract |
We evaluated the co-related pathogenesis between viruses and bacteria in acute otitis media. Respiratory viruses were identified in about 9. 7% of middle ear fluid(MEF) from acute otitis media(AOM). We found positive correlation between detection of human vocavirus(HBoV) and Streptococcus pneumoniae in the MEF. HBoV may worsen the clinical symptoms and prolong the clinical outcome of AOM in pediatric population. Viral infection may prime the secondary bacterial infection in the middle ear and the improvement of AOM becomes significantly slower.
rhinovirus(RV) infections are also reported to increase platelet activating factor receptor(PAF-R) expression on cultured cells and a specific inhibitor of the PAF-R decreased the number of S. pneumoniae adhering to the cells. These findings suggest that viral infection stimulates S. pneumoniae adhesion to airway epithelial cells.
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Report
(4 results)
Research Products
(99 results)
