Hearing functional analysis of fibrinolytic components gene mutant mice

• Project/Area Number: 21592166
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Jichi Medical University
• Principal Investigator: ISHIKAWA Kotaro 自治医科大学, 医学部, 講師 (60347987)
• Co-Investigator(Kenkyū-buntansha): MADOIWA Seiji 自治医科大学, 医学部, 講師 (70296119) ; SAKATA Youichi 自治医科大学, 医学部, 教授 (40129028) ; ISHIMURA Keiichi 自治医科大学, 医学部, 教授 (00010471) ; 中村 謙一 自治医科大学, 医学部, 研究員 (10448855)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 耳科学 / 感音難聴 / 線溶系遺伝子

Research Abstract

We studied hearing and histopathological findings of cochlea in tissue-type plasminogen activator(tPA)-deficient mice, plasminogen(Plg)-deficient mice, and plasminogen activator inhibitor-1(PAI-1)-deficient mice. We cannot detect any significant difference of hearing level and histological findings between C57BL/6J tPA/mice and wild type(WT) mice in 18 and 24 months age. We also analyzed the C57BL/6J Plg./. and the C57BL/6J PAI-1./. mice at the age of 8 months. These mice showed normal hearing level and histological findings of cochlea. In conclusion, we cannot detect any significant difference of audiological function and histopathology of cochlea between fibrinolytic components gene mutant mice and wild type mice.