A study regarding sensorineural hearing impairment with morphological changes in stria vascularis induced by the administration of Arg-Vasopressin
| Project/Area Number |
21592167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Katsumasa 北里大学, 医学部, 教授 (70134525)
SAKAGAMI Hiroyuki 北里大学, 医学部, 教授 (90261528)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Arg-vasopressin / Meniere's disease / V2R antagonist / V1aR antagonist / hydration therapy / Arg-Vasopressin / 血管条 / 中間細胞 / 液胞 / 内リンパ水腫 / 聴力低下 / 酸素分圧 / メニエール病 / 浮腫 |
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| Research Abstract |
Wistar rats were intraperitoneally injected 0.02 units/g of AVP (Pitressin; Arg-vasopressin. Daiichi-Sankyo, Japan)in the all experiments in this study. ABR thresholds gradually increased significantly upto 60 min after the injection. When the dehydration load pretreatment for 24h was added, ABR thresholds rapidly increased significantly up to 10 min after the injection. However, the morphological endolymphatic hydrops in cochlea was not detected under a light microscopy. However, the enlargement of an area lacking intracellular organelles in the intermediate cells in stria vascularis or a so called “vacuole” was detected under transmission electron microscopy after the AVP injection. When the dehydration load pretreatment for 24h was added, the vacuole area increased with AVP injection. However, when the V2Rantagonist (OPC-31260, donated by Otsuka Pharmaceutical) was administered before AVP,vacuole formation was suppressed significantly. Conversely, vacuole formation was not suppressed when the V1aR antagonist (OPC-21268, donated by Otsuka Pharmaceutical) was administered before AVP injection.
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Report
(4 results)
Research Products
(80 results)
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[Journal Article]2010
Author(s)
長沼英明
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Journal Title
今日の治療指針2010年版動揺病(乗り物酔い)vol 52(医学書院)
Pages: 832-833
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[Journal Article]2009
Author(s)
徳増厚二、長沼英明
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Journal Title
「イラストめまいの検査」改訂第2版 (日本めまい平衡医学会編)(株式会社 診断と治療社)
Pages: 76-79
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[Presentation] Peak Audiogram of Meniere's Disease2010
Author(s)
Ochiai A, Naganuma H, Tokumasu K, Okamoto M
Organizer
6th International Symposium on Meniere's Disease and Inner Ear Disorders
Place of Presentation
Kyoto International Conference Center(京都府)
Year and Date
2010-11-15
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[Presentation] めまいのリハビリ2010
Author(s)
長沼英明
Organizer
第27回日本めまい平衡医学会医師講習会
Place of Presentation
山口大学医学部(山口県)
Year and Date
2010-06-25
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[Presentation] 理学療法2010
Author(s)
長沼英明
Organizer
第27回日本めまい平衡医学会医師講習会
Place of Presentation
山口大学医学部(山口県)
Year and Date
2010-06-25
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[Presentation] 突発性難聴の眼振所見と聴力予後2009
Author(s)
落合敦, 長沼英明, 徳増厚二, 伊藤昭彦, 和田昌興, 岡本牧人
Organizer
第68回日本めまい平衡医学会総会・学術講演会
Place of Presentation
徳島
Year and Date
2009-11-26
Related Report
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[Presentation] メニエール病と低血圧(第2報)2009
Author(s)
伊藤昭彦, 長沼英明, 和田昌興, 落合敦, 牧野寛之, 那須野智光, 徳増厚二, 岡本牧人
Organizer
第68回日本めまい平衡医学会総会・学術講演会
Place of Presentation
徳島
Year and Date
2009-11-26
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