Immunological prevention of age-related hearing loss : analysis of its molecular biological mechanisms

• Project/Area Number: 21592170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kansai Medical University
• Principal Investigator: IWAI Hiroshi 関西医科大学, 医学部, 准教授 (10232638)
• Co-Investigator(Kenkyū-buntansha): INABA Muneo 関西医科大学, 医学部, 非常勤講師 (70115947)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 老人性難聴 / 免疫老化 / IL-1R2 / CD4^+T細胞 / 胎児胸腺 / Treg / 浸透圧ポンプ / CD4+T細胞 / IL-7 / KGF / ヘルパーT細胞 / 移植 / up regulation / 加齢 / interleukin 1 receptor types II / 胸腺 / 遺伝子 / mRNA

Research Abstract

We found that rejuvenation of the recipient immunity by inoculation of young CD4^+T cells or a fetal thymus graft led to down regulation of the interleukin 1 receptor type II(IL-1R2) gene in CD4^+T cells and reduced age-related hearing loss in SAMP1 mice, a murine model of human senescence. Our studies on the relationship between age-related systemic immune dysfunctions and neurodegeneration mechanisms open up new avenues of treatment of neurosenescence, including presbycusis, for which there is no effective therapy.

Research Products

• [Journal Article] Amelioration of 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells (2011)
  • Author(s): Hoshino S, Kurishima A, Inaba M, Ando Y, Fukui T, Uchida K, Nishio A, Iwai H, Yokoi T, Ito T, Hasegawa-Ishii S, Shimada A, Li M, Okazaki K, Ikehara S
  • Journal Title: J Gastroenterol Volume: 46 Pages: 1368-81
  • NAID: 10030295176
  • Peer Reviewed
• [Journal Article] Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells (2011)
  • Author(s): Uchida K, Nishio A, Iwai H, Yokoi T, Ito T, Hasegaw
  • Journal Title: J Gastroenterol Volume: 46
  • NAID: 10030295176
  • Peer Reviewed
• [Journal Article] The role of dendritic cell subsets in 2, 4, 6-Trinitrobenzene sulfonic acid-induced ileitis (2010)
  • Author(s): Hoshino S, Inaba M, Iwai H, Ito T, Li M, Gershwin ME, Okazaki K, Ikehara S
  • Journal Title: J Autoimmunity Volume: 34 Pages: 380-389
  • Peer Reviewed
• [Journal Article] The role of dendritic cell subsets in 2,4,6-Trinitrobenzene sulfonic acid-induced ileitis. (2010)
  • Author(s): Hoshino S, Inaba M, Iwai H, Ito T, Li M, Gershwin ME, Okazaki K, Ikehara S
  • Journal Title: J Autoimmunity Volume: 34 Pages: 380-389
  • Peer Reviewed
• [Journal Article] Induction of parotitis by fine-needle aspiration in parotid Warthin's tumor (2009)
  • Author(s): Suzuki S, Iwai H, Kaneko T, Sakaguchi M, Hoshino S, Inaba M
  • Journal Title: Otolaryngol Head Neck Surg Volume: 141 Pages: 282-284
  • Peer Reviewed
• [Journal Article] Parotid mucosa-associated lymphoid tissue lymphoma regression after Helicobacter Pylori eradication (2009)
  • Author(s): Iwai H, Nakamichi N, Nakae K, Konishi M, Inaba M, Hoshino S, Baba S. Amakawa R
  • Journal Title: Laryngoscopel Volume: 19 Pages: 1491-1494
  • Peer Reviewed
• [Journal Article] Parotid mucosa-associated lymphoid tissue lymphoma regression after Helicobacter Pylori eradication (2009)
  • Author(s): Iwai H, Nakamichi N, Nakae K, Konishi M, Inab Ma, Hoshino S, Baba S.Amakawa R
  • Journal Title: Laryngoscope 119 Pages: 1491-1494
  • Peer Reviewed
• [Journal Article] Induction of parotitis by fine-needle aspiration in parotid Warthin's tumor (2009)
  • Author(s): Suzuki S, Iwai H, Kaneko T, Sakaguchi M, Hoshino S, Inaba M
  • Journal Title: Otolaryngol Head Neck Surg 141 Pages: 282-284
  • Peer Reviewed
• [Journal Article] Fetal Thymus Graft Prevents Age-Related Hearing Loss and Up Regulation of the IL-1 Receptor Type II Gene in CD4^+T cells
  • Author(s): Iwai H, Inaba M
  • Journal Title: J Neuroimmunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Fetal Thymus Graft prevents Age-Related Hearing Loss and Up Regulation of the IL-1 Receptor Type II Gene in CD4+ T cells
  • Author(s): Iwai H, Inaba M
  • Journal Title: J Neuroimmunol Volume: (掲載確定)
  • Peer Reviewed
• [Presentation] Fetal Thymus Graft Prevents Presbycusis and Age-Related Up Regulation of The IL-1 Receptor Type II Gene in Helper T cells (2011)
  • Author(s): Iwai H, Inaba M, Baba S, Tomoda K
  • Organizer: The 48th Inner Ear Biology Workshop
  • Place of Presentation: Lisbon, Portugal
• [Presentation] tal Thymus Graft Prevents Presbycusis and Age-Related Up Regulation of The IL-1 Receptor Type II Gene in Th cell (2011)
  • Author(s): Iwai H, Inaba M, Baba S, Tomoda K
  • Organizer: The 48th Inner Ear Biology Workshop
  • Place of Presentation: Lisbon. Portugal
• [Presentation] Immunological and genetical influence of systemic helper T cell on age-related cochlear functions (2010)
  • Author(s): Iwai H, Inaba M, Baba S, Sakaguchi M, Ikehara S, Tomoda T
  • Organizer: 47th Inner Ear Biology Workshop
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Immunological and genetical influence of systemic helper T cell on age-related cochlear functions. (2010)
  • Author(s): Hiroshi Iwai, Muneo Inaba, susumu Baba, mariko Sakaguchi, Susumu Ikehara, Koichi Tomoda
  • Organizer: 47th Inner Ear Biology Workshops
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Inoculation of helper T cells as a strategy for the prevention of age-related hearing loss in SAMP1 mice (2009)
  • Author(s): Iwai H, Baba, Inaba M, Sakaguchi M, Lee S, Ikehara S, Tomoda K
  • Organizer: 48th Workshop on Inner Ear Biology
  • Place of Presentation: Utreht, The Netherland
• [Presentation] Preventive effects of thymus graft on age-related hearing loss (2009)
  • Author(s): Baba S, Iwai H, Inaba M, Sakaguchi M, Lee S, Ikehara S, Tomoda K
  • Organizer: 48th Workshop on Inner Ear Biology
  • Place of Presentation: Utreht, The Netherland
• [Presentation] T細胞機能維持による進行性老人性難聴予防 (2009)
  • Author(s): 岩井大、坂口麻理子、馬場奨、李進隆、友田幸一
  • Organizer: 第19回日本耳科学会
• [Presentation] T細胞機能維持による進行性老人性難聴予防 (2009)
  • Author(s): 岩井大, 坂口麻理子, 馬場奨, 李進隆, 友田幸一
  • Organizer: 第19回日本耳科学会
  • Place of Presentation: 京王プラザホテル、東京
• [Presentation] Inoculation of helper T cells as a strategy for the prevention of age-related hearing loss in SAMP1 mice (2009)
  • Author(s): Iwai H, Baba, Inaba M, Sakaguchi M, Lee S, Ikehara S, Tomoda K
  • Organizer: 48th Workshop on Inner Ear Biology
  • Place of Presentation: Utrecht, The Netherland
• [Presentation] Preventive effects of thymus graft on age-related hearing loss (2009)
  • Author(s): Baba S, Iwai H, Inaba M, Sakaguchi M, Lee S, Ikehara S, Tomoda K
  • Organizer: 48th Workshop on Inner Ear Biology
  • Place of Presentation: Utrecht, The Netherland