The investigation of SIRT1 for permanent cure of allergic rhinitis

• Project/Area Number: 21592173
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: NAKAMARU Yuji 北海道大学, 北海道大学病院, 講師 (20344509)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: SIRT1 / IL-4 / 肥満細胞

Research Abstract

To investigate the role of SIRT1 for the production of IL-4 in human mast cell, we used activator and inhibitor of SIRT1. Cells treated with SIRT1 activator decreased IL-4 production. On the other hand, the SITR1 inhibitor increased IL-4 production in human mast cells.
The SIRT1 protein thought to be negatively modulate IL-4 production in human mast cell.

Research Products

• [Journal Article] The Otolaryngologic Manifestations of Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis (2012)
  • Author(s): Nakamaru Y, Takagi D, Oridate N, Homma A, and Fukuda S
  • Journal Title: Otolaryngology-Head and Neck Surgery Volume: 146 Pages: 129-131
  • Peer Reviewed
• [Journal Article] アレルギー性鼻炎の診断と治療-薬剤師の皆さまにお願いしたいこと- (2012)
  • Author(s): 中丸裕爾
  • Journal Title: 北海道薬剤師会雑誌 Volume: 28 Pages: 70-72
• [Journal Article] 私の処方箋,再発性多発軟骨炎 (2012)
  • Author(s): 中丸裕爾
  • Journal Title: Johns Volume: 27 Pages: 1518-1519
• [Journal Article] 私の処方箋再発性多発軟骨炎 (2011)
  • Author(s): 中丸裕爾
  • Journal Title: Johns Volume: 27 Pages: 1518-1519
• [Journal Article] 第38回鼻科学臨床問題懇話会鼻副鼻腔病変の治療決断の時ー炎症から癌までー鼻副鼻腔inverted papilomaのマネ-ジメント (2010)
  • Author(s): 中丸裕爾
  • Journal Title: 日本鼻科学会 Volume: 49 Pages: 56-58
• [Journal Article] Preservation of the nasolacrimal duct during endoscopic medial maxillectomy for sinonasal inverted papilloma (2010)
  • Author(s): Nakamaru Y, Furuta Y, Takagi D, Oridate N and Fukuda S
  • Journal Title: Rhinology Volume: 48 Pages: 452-456
  • Peer Reviewed
• [Journal Article] Sublingual Immunotherapy with House Dust Extract for House Dust-Mite Allergic Rhinitis in Children (2010)
  • Author(s): Yonekura S, Okamoto Y, Sakurai D, Horiguchi S, Hanazawa T, Nakano A, Nakamaru Y, et al
  • Journal Title: Allergollogy International Volume: 59 Pages: 1-20
  • NAID: 10029671183
  • Peer Reviewed
• [Journal Article] <第38回鼻科学臨床問題懇話会>鼻副鼻腔病変の治療決断の時-炎症から癌まで-「鼻副鼻腔inverted papilomaのマネージメント (2010)
  • Author(s): 中丸裕爾
  • Journal Title: 日本鼻科学会 Volume: 49 Pages: 56-58
• [Journal Article] Preservation of the nasolacrimal duct during endoscopic medial maxillectom for sinonasal inverted papilloma. (2010)
  • Author(s): Nakamaru Y, Furuta Y, Takagi D, Oridate N, Fukuda S
  • Journal Title: Rhinology Volume: 48 Pages: 452-456
  • Peer Reviewed
• [Journal Article] Sublingual Immunotherapy with House Dust Extract for House Dust-Mite Allergic Rhinitis in Children. (2010)
  • Author(s): Yonekura S, Okamoto Y, Sakurai D, Horiguchi S, Hanazawa T, Nakano A, Nakamaru Y, et al.
  • Journal Title: Allergollogy International Volume: 59 Pages: 1-20
  • NAID: 10029671183
  • Peer Reviewed
• [Journal Article] A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9 (2009)
  • Author(s): Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K
  • Journal Title: FASEB Volume: 23 Pages: 2810-2819
  • Peer Reviewed
• [Journal Article] A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. (2009)
  • Author(s): Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K.
  • Journal Title: FASEB J. 23 Pages: 2810-2819
  • Peer Reviewed
• [Presentation] Modified Lothrop Procedureにより内視鏡的に切除した前頭洞内に茎を持つ内反性乳頭腫症例 (2011)
  • Author(s): 中丸裕爾
  • Organizer: 第50回日本鼻科学会総会・学術講演会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
  • Year and Date: 2011-12-02
• [Presentation] A new nasolacrimal duct preserve technique for endoscopic medial maxillectomy (2011)
  • Author(s): 中丸裕爾
  • Organizer: 第14回国際鼻科学会議(IRS)・第30回国際感染鼻科アレルギーシンポジウム(ISIAN)
  • Place of Presentation: ANA InterContinental Tokyo(東京都)
  • Year and Date: 2011-09-20
• [Presentation] 鼻副鼻腔内反性乳頭腫に対する内視鏡下内側上顎切除術における鼻涙管保存法 (2011)
  • Author(s): 中丸裕爾
  • Organizer: 第112回日本耳鼻咽喉科学会総会・学術講演会
  • Place of Presentation: 国立京都国際会館(京都市)
  • Year and Date: 2011-05-20
• [Presentation] 耳鼻咽喉科領域におけるANCA関連血管炎症候群: PR3-ANCA陽性症例とMPO-AMCA陽性症例の臨床症状の差異 (2011)
  • Author(s): 中丸裕爾
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 全日空ホテルオアシスタワー(大分市)
  • Year and Date: 2011-02-11
• [Presentation] 耳鼻咽喉科領域におけるANCA関連血管炎症候群:PR3-ANCA陽性症例とMPO-AMCA陽性症例の臨床症状の差異 (2011)
  • Author(s): 中丸裕爾
  • Organizer: 第29回日本耳鼻咽喉科免疫アレルギー学会
  • Place of Presentation: 全日空ホテルオアシスタワー(大分市)
  • Year and Date: 2011-02-11
• [Presentation] Otolaryngological features of ANCA associated vasculitis (2011)
  • Author(s): Nakamaru Y
  • Organizer: American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting
  • Place of Presentation: Moscone Center(米国・サンフランシスコ)
• [Presentation] Otolaryngological features of ANCA associated vasculitis (2011)
  • Author(s): Yuji Nakamaru
  • Organizer: American Academy of Otolaryngology-Head and Neck Surgery Foundation Annual Meeting
  • Place of Presentation: 米国(招待講演)(ポスター発表)
• [Presentation] ANCA関連血管炎症候群の耳症状 (2010)
  • Author(s): 中丸裕爾
  • Organizer: 第60回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-11-25
• [Presentation] SIRT1 regulates IL-4 gene expression in human mast cell (2010)
  • Author(s): Nakamaru Y
  • Organizer: Europe Rhinologic Society & 29th ISIAN
  • Place of Presentation: Centre International de Conference Geneve(Geneva・Switzerland)
• [Presentation] SIRT1 regulates IL-4 gene expression in human mast cell. (2010)
  • Author(s): Nakamaru Y
  • Organizer: Europe Rhinologic Society & 29th ISIAN
  • Place of Presentation: Centre International de Conference Geneve (Geneva・Switzerland)
• [Presentation] 難治性前頭洞.胞に対するFrontal trephnatio (2009)
  • Author(s): 中丸裕爾
  • Organizer: 第11回耳鼻咽喉科手術支援システム・ナビ研究会
  • Place of Presentation: 石川県教育会館2F第1会議室(金沢市)
  • Year and Date: 2009-11-14
• [Presentation] 肥満細胞におけるSIRT1によるIL-4産生調節 (2009)
  • Author(s): 中丸裕爾
  • Organizer: 第59回日本アレルギー学会秋季学術大会
  • Place of Presentation: 秋田キャッスルホテル他(秋田市)
  • Year and Date: 2009-10-31
• [Presentation] 鼻副鼻腔inverted papillomaのマネージメント (2009)
  • Author(s): 中丸裕爾
  • Organizer: 第48回日本鼻科学会学術講演会
  • Place of Presentation: 島根県民会館他(松江市)
  • Year and Date: 2009-10-01
• [Book] 第48回日本鼻科学会学術講演会 第59回日本アレルギー学会秋季学術大会