The investigation of SIRT1 for permanent cure of allergic rhinitis
| Project/Area Number |
21592173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NAKAMARU Yuji 北海道大学, 北海道大学病院, 講師 (20344509)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | SIRT1 / IL-4 / 肥満細胞 |
|---|
| Research Abstract |
To investigate the role of SIRT1 for the production of IL-4 in human mast cell, we used activator and inhibitor of SIRT1. Cells treated with SIRT1 activator decreased IL-4 production. On the other hand, the SITR1 inhibitor increased IL-4 production in human mast cells.
The SIRT1 protein thought to be negatively modulate IL-4 production in human mast cell.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-92009
Author(s)
Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K
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Journal Title
FASEB
Volume: 23
Pages: 2810-2819
Related Report
Peer Reviewed
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[Journal Article] A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9.2009
Author(s)
Nakamaru Y, Vuppusetty C, Wada H, Milne JC, Ito M, Rossios C, Elliot M, Hogg J, Kharitonov S, Goto H, Bemis JE, Elliott P, Barnes PJ, Ito K.
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Journal Title
FASEB J. 23
Pages: 2810-2819
Related Report
Peer Reviewed
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